Editors: K. Tamreihao, Saikat Mukherjee, Debananda S. Ningthoujam

Series Title: Frontiers in Anti-Infective Agents

Current Perspectives on Anti-Infective Agents

Volume 1

eBook: US $129 Special Offer (PDF + Printed Copy): US $219
Printed Copy: US $155
Library License: US $516
ISBN: 978-981-14-3272-9 (Print)
ISBN: 978-981-14-3273-6 (Online)
Year of Publication: 2019
DOI: 10.2174/97898114327361190101

Introduction

The volume is a comprehensive documentation on major infectious diseases from tropical countries which pose a serious threat to global healthcare programs. These include diseases such as tuberculosis, AIDS, leishmaniasis (kala-azar), elephantiasis, malaria, leprosy, various fungal disorders, and emergent viral diseases. Due to the widespread use of antibiotics, there is an emergence of drug-resistant pathogens in many regions. Hence, there is a need to search for novel, cost-effective bioactive compounds that demonstrate high efficacy and low toxicity in human cells from unexplored ecosystems to combat emerging drug-resistant pathogens. Chapters of this volume focus on the pathogenesis and etiology of each of the mentioned diseases, updated WHO reports wherever applicable, conventional drugs and their pharmacokinetics as well as new approaches to develop anti-infective agents.

The authors also present a detailed report on ‘superbugs’ (multi-drug resistant pathogens) and new measures being taken up to eradicate them. Information about new antimicrobials (bioactive peptides and silk protein sericin) and the approaches taken by scientists and healthcare professionals for successful targeting of these molecules for human medicine. This volume is essential for general readers, healthcare professionals, researchers, and academicians actively involved in research on infectious diseases and anti-infective therapeutic drugs.

Preface

- Pp. i-iii (3)
K. Tamreihao and Debananda S. Ningthoujam
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List of Contributors

- Pp. iv-v ()
Debananda S. Ningthoujam
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Prospects of Actinobacteria from Underexplored Ecosystems as Anti-infective Agents against Mycobacterium tuberculosis

- Pp. 1-20 (20)
K. Tamreihao, Saikat Mukherjee, Debananda S. Ningthoujam and Subhra Saikat Roy

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Protozoan and Helminth Infections: Epidemiology and Anti Infective Therapy

- Pp. 21-43 (23)
Saikat Mukherjee, K. Tamreihao, Rakhi Khunjamayum, Khullakpam Shaheen, Elangbam Shanta Singh, Debananda S. Ningthoujam and Sumita Banerjee

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Therapeutic Drugs Used for Effective Lifelong Control of HIV and AIDS

- Pp. 44-66 (23)
Elangbam Shanta Singh, Debananda S. Ningthoujam, Laishram Jaya Devi, Rakhi Khunjamayum, Dollyca Ningombam and Laishram Somenkumar Singh

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Bioactive Peptides and Their Therapeutic Potential as Antimicrobial Drugs

- Pp. 67-85 (19)
Pintubala Kshetri, Thangjam Surchandra Singh and Subhra Saikat Roy

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Drugs for Superbugs: Strategies and Methods to Discover New Antibiotics against Drug Resistant Pathogens

- Pp. 86-105 (20)
Debananda S. Ningthoujam and Khullakpam Shaheen

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Antifungal Agents: Therapeutic Approaches and Future Perspectives

- Pp. 106-125 (20)
Rakhi Khunjamayum, Roshan Singh Asem, Laishram Jaya Devi, K. Tamreihao and Debananda S. Ningthoujam

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Emerging Viral Diseases and Potential Therapeutic Agents for Their Control

- Pp. 126-160 (35)
Sumita Banerjee

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Leprosy: Clinical / Diagnostic Features and Current Status of Anti-leprosy Drugs

- Pp. 161-182 (22)
Khullakpam Shaheen, Ibemhal D. Asem and Debananda Singh Ningthoujam

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Silk Protein Sericin: Structure, Secretion, Composition and Antimicrobial Potential

- Pp. 183-194 (12)
Shamjetshabam Babeeta Chanu, Sanjenbam Kunjeshwori Devi and Laishram Rupachandra Singh

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Understanding the Realm of Antibiotics: Mechanisms of Action and Their Applications as Anti-infective Agents

- Pp. 195-221 (27)
Laishram Jaya Devi, Rakhi Khunjanmayum, Roshan Singh Asem, Elangbam Shanta Singh, Sumita Banerjee and Debananda S. Ningthoujam

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The Use of Medicinal Plants in the Treatment of Malaria

- Pp. 222-244 (23)
Ibemhal D. Asem, Khullakpam Shaheen and Debananda S. Ningthoujam

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Subject Index

- Pp. 245-260 (16)
K. Tamreihao and Debananda S. Ningthoujam
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