Editors: Shankar Suman, Shivam Priya, Akanksha Nigam

Breast Cancer: Current Trends in Molecular Research

eBook: US $79 Special Offer (PDF + Printed Copy): US $126
Printed Copy: US $87
Library License: US $316
ISBN: 978-1-68108-953-9 (Print)
ISBN: 978-1-68108-952-2 (Online)
Year of Publication: 2022
DOI: 10.2174/97816810895221120101


Breast cancer is one of the most common cancer types worldwide, and is a leading cause of cancer related deaths in women. In this book, medical experts review our current understanding of the molecular biology and characteristics of breast cancer. The topics covered in this book provide comprehensive knowledge of mechanisms underlying breast carcinogenesis, and are intended for a wide audience including scientists, teachers, and students.

11 chapters present information about several topics on breast cancer, including the role of cell growth and proliferation pathways, androgen and cytokine signaling, germline mutations in breast cancer susceptibility genes, and molecular factors causing invasive and metastatic breast cancer. In addition, the editors discuss the recent advancements in multi-omics data analysis based on inter-and intra-tumor molecular profiles.

The reference highlights how the knowledge and understanding of the biological behavior of breast neoplasms have facilitated ongoing investigations into dietary polyphenolic compounds with antioxidant properties, making them function as cancer chemopreventive agents. Along with this, the current development of treatment strategies such as targeted molecular therapy, and radiation therapy is brought to the fore to update readers.


Breast cancer is the most frequent malignancy in women worldwide. It is associated with several risk factors including mutations, inheritance, and environmental factors. The heterogeneity in breast cancer cells shows the complexity of this disease. Despite newer day-to-day developments in cancer research, advanced breast cancer is still challenging to manage. The scientific innovation in breast cancer research has led to an increase in patient's overall survival in the last few decades. For example- the discovery of sensitive screening tools enhanced early-stage detection of breast cancer and further novel treatment regimens improved therapeutic benefits. The current research is also focused on developing new surgical modalities that are minimally invasive, and new radiation modalities with minimal side effects. This book is intended to target a broad audience who has an interest in breast cancer research and therapy. We have incorporated chapters delineating the recent studies on breast cancer with an emphasis on etiology, diagnosis, and therapy. Chapters uncover the new updated information on breast cancer signaling, immune-response, DNA damage, and epigenetic modifications with bioinformatics resources. The book will allow readers to review the data of numerous studies on immunotherapy and gene therapy as well. The latest concept on the use of nanotechnology in breast cancer, has also been reviewed in detail as nanotechnology has opened a paradigm shift in targeted drug delivery in breast cancer. The specific chapter also shows the importance of dietary polyphenol and its role in breast cancer. The application of radiotherapy in breast cancer is also well described, which will be helpful to gain the concept of clinical radiotherapy. In overall, chapters are organized to give the readers a practical and efficient way to familiarize themselves with the newest ongoing research in the field of breast cancer.

Shankar Suman
Comprehensive Cancer Center
The Ohio State University

Shivam Priya
Comprehensive Cancer Center
The Ohio State University


Akanksha Nigam
Department of Microbiology and Molecular Genetics
IMRIC, the Hebrew University-Hadassah Medical School