Editors: Kamal Niaz, Muhammad Farrukh Nisar

Series Title: Coronavirus Disease-19 (COVID-19): A Perspective of New Scenario

(COVID-19): Different Models and Treatment Strategies

Volume 2

eBook: US $79 Special Offer (PDF + Printed Copy): US $134
Printed Copy: US $95
Library License: US $316
ISBN: 978-1-68108-908-9 (Print)
ISBN: 978-1-68108-907-2 (Online)
Year of Publication: 2021
DOI: 10.2174/97816810890721210201


In this book volume-2 proposal has been classified into Part IV: Models for SARS-CoV-2 and Part V: Treatment Strategies for SARS-CoV-2. With the emergence of new coronavirus variants, epidemiology, different host tropism permits a thorough analysis of their evolution and acquired adaptability to their host which need different animal models and treatment approaches. No studies are complete without animal models closely related to human physiology to replicate the disease and observe the pathology conditions as in human cases. Such animal models play a vital role in virus pathogenesis and prepare a therapeutic immune response. Here describe bio-engineered transgenic mouse model inserting with specific genes, or CRISPR-Case9 gene-editing tool has been used previously for SARS-CoV and MERS-CoV. The chapter will deal with culture techniques or cell lines for COVID-19—also histopathology of COVID-19, essential proteins that up or down-regulate SARS-CoV-2. The last chapter of this part will describe other diseases having similar signs and symptoms and their differentiation. There is no specific treatment available to date, just symptomatic therapy. However, scientists will elucidate effective antiviral drugs in clinical trials, phytochemicals, photomedicine such as ultraviolet A & B, homemade remedies, blood plasma transfusion, stem cell therapy, and computational approaches in vivo and in vitro trials. This book will appear as a baseline for academicians, scientists, and health professionals as still, research is going to overcome this outbreak of COVID-19, the novelty of best animal models, and find an effective treatment. However, just a single book proposal like this wouldn't have flourished without enthusiasm and determined publishers' and investigators' strength to take time from their busy schedule and subsidize on time. We thank the whole investigators who contributed, directly and indirectly, to bring it to reality.


According to World Health Organization, 122 million cases and over 2.69 million deaths of coronavirus disease-2019 (COVID-19) pandemic have impacted nearly every region of the globe. The pandemic has a huge global economic influence, and successfully fighting against COVID-19 needs efforts. Newly emerging respiratory diseases such as Severe Acute Respiratory Syndrome-coronavirus (SARS-CoV), Middle East Respiratory Syndrome (MERS), and severe acute respiratory syndrome-coronavirus-2 (SARS-CoV-2) posing a serious threat to the human population and reported in the years 2003, 2012, and 2019, respectively. Furthermore, SARS-CoV-2 new strains shocked the world due to genetic mutation over time.

This book is very relevant and consists of two key modules. The first module provides clear information regarding different animals and cell line models and differentiation from other respiratory diseases. The second part focuses on therapeutic agents (antivirals, natural compounds, ultraviolet radiation, herbal remedies, blood plasma, stem cell therapy, and vaccines. It will give step-by-step awareness to the scholars about SARS-CoV-2. Basic and advanced knowledge about the disease is arranged into clear and easy-to-read chapters for general readers, scholars, and molecular biology teachers, making this book a valuable and thorough guide for all.

Prof. Dr. Zahir Shah
University of Chitral
Chitral Khyber Pakhtunkhwa


.Frontiers in Antimicrobial Agents Vol. 2, Current Trends in the Identification and Development of Antimicrobial Agents.
.Hepatitis C Virus-Host Interactions and Therapeutics: Current Insights and Future Perspectives.
.An Update on SARS-CoV-2: Damage-response Framework, Potential Therapeutic Avenues and the Impact of Nanotechnology on COVID-19 Therapy.