Editors: Kamal Niaz, Muhammad Farrukh Nisar

Series Title: Coronavirus Disease-19 (COVID-19): A Perspective of New Scenario

(COVID-19): Different Models and Treatment Strategies

Volume 2

eBook: US $79 Special Offer (PDF + Printed Copy): US $134
Printed Copy: US $95
Library License: US $316
ISBN: 978-1-68108-908-9 (Print)
ISBN: 978-1-68108-907-2 (Online)
Year of Publication: 2021
DOI: 10.2174/97816810890721210201

Introduction

In this book volume-2 proposal has been classified into Part IV: Models for SARS-CoV-2 and Part V: Treatment Strategies for SARS-CoV-2. With the emergence of new coronavirus variants, epidemiology, different host tropism permits a thorough analysis of their evolution and acquired adaptability to their host which need different animal models and treatment approaches. No studies are complete without animal models closely related to human physiology to replicate the disease and observe the pathology conditions as in human cases. Such animal models play a vital role in virus pathogenesis and prepare a therapeutic immune response. Here describe bio-engineered transgenic mouse model inserting with specific genes, or CRISPR-Case9 gene-editing tool has been used previously for SARS-CoV and MERS-CoV. The chapter will deal with culture techniques or cell lines for COVID-19—also histopathology of COVID-19, essential proteins that up or down-regulate SARS-CoV-2. The last chapter of this part will describe other diseases having similar signs and symptoms and their differentiation. There is no specific treatment available to date, just symptomatic therapy. However, scientists will elucidate effective antiviral drugs in clinical trials, phytochemicals, photomedicine such as ultraviolet A & B, homemade remedies, blood plasma transfusion, stem cell therapy, and computational approaches in vivo and in vitro trials. This book will appear as a baseline for academicians, scientists, and health professionals as still, research is going to overcome this outbreak of COVID-19, the novelty of best animal models, and find an effective treatment. However, just a single book proposal like this wouldn't have flourished without enthusiasm and determined publishers' and investigators' strength to take time from their busy schedule and subsidize on time. We thank the whole investigators who contributed, directly and indirectly, to bring it to reality.

Foreword

- Pp. i
Zahir Shah
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Preface

- Pp. ii-iii (2)
Kamal Niaz and Muhammad Farrukh Nisar
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List of Contributors

- Pp. iv-vi (3)

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Genetically Engineered Mouse Models for COVID- 19

- Pp. 1-19 (19)
Aadil Javed*, Kamal Niaz and Ovais Sideeq

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Different Cell Lines for SARS-CoV-2

- Pp. 20-51 (32)
Sonali Bajaj, Neha Sharma, Abhinav Anand, Devesh Tewari and Navneet Khurana*

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Histopathologic Evaluation and Scoring of SARSCoV- 2 Infection

- Pp. 52-71 (20)
Muhammad Mazhar Ayaz*, Ihtisham Ulhaq and Kashif Rahim

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Key Proteins and Their Roles in COVID-19

- Pp. 72-104 (33)
Amjad Islam Aqib*, Iqra Muzammil, Qaisar Tanveer, Tean Zaheer and Aisha Mahmood

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Differential Diagnosis of COVID-19

- Pp. 105-143 (39)
Amjad Islam Aqib*, Iqra Muzammil, Qaisar Tanveer, Sana Muzammal, Amna Ahmad, Firasat Hussain and Kashif Rahim

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Different Antiviral Drugs against COVID-19 and Future Perspective

- Pp. 144-174 (31)
Iyad Ibrahim Shaqura, Ahmed Abdelmajed Alkhodary, Abdullah, Muhammad Ibrar and Fazlullah Khan*

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Phytochemicals Effective against COVID-19 and Future Perspective

- Pp. 175-191 (17)
Afshan Shafi, Kashif Akram, Ismail Shah and Fazlullah Khan*

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Ultraviolet Radiation A (UVA): Modulates the Production of Nitric Oxide (NO) to Combat COVID-19

- Pp. 192-218 (27)
Muhammad Farrukh Nisar*, Ahmad Uddin, Kamal Niaz, Shaukat Hussain Munawar, Qudratullulah, Faisal Siddique, Muhammad Yasir Waqas and Ahmad Farooq

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Herbal Remedies Effective against COVID-19

- Pp. 219-252 (34)
Laiba Hassan, Muhammad Ali Syed* and Mohammad Ejaz

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Role of Blood Plasma Transfusion Against COVID-19

- Pp. 253-265 (13)
Muhammad Ibrar, Abdullah, Iyad Ibrahim Shaqura, Ahmed Abdelmajed Alkhodary and Fazlullah Khan*

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Stem Cell Therapy for COVID-19

- Pp. 266-287 (22)
Ovais Sideeq*, Kamal Niaz, Kashif Rahim and Aadil Javed

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Computational Methods for COVID-19 Treatment

- Pp. 288-313 (26)
Zahid Manzoor*, Shaukat Hussain Munawar, Muhammad Farrukh Nisar, Muhammad Yasir Waqas and Muhammad Mazhar Munir

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Vaccine Development, Advantages, and Disadvantages of Group Immunity and Future Perspective for COVID-19

- Pp. 314-336 (23)
Abdullah, Maqsood ur Rehman, Fazlullah Khan* and Tapan Behl

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Subject Index

- Pp. 337-348 (12)

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