Preface

This book “Biochemical Mechanisms of Aluminium Induced Neurological Disorders” is composed of six chapters contributed by reputed scientists working in the field of metals neurotoxicity and studying the role of metals on various neurological disorders. The salient features of this book which make it unique are– it highlights the basic as well as clinical mechanisms of metals induced neurotoxicity in various neurological disorders, and another unique feature of this book is that it discusses the role of Aluminium induced neurological disorders, alone and in combination with other toxic metals as well as with the high fat diet intake, thus adding diversity and unraveling new features of metals neurotoxicity in real scenarios.

Aluminium is present in the earth’s crust and it is a well known environmental toxin/metal which has been found to be associated with various neurological disorders. Aluminium has been found to be a very strong risk factor for the development of Alzheimer’s disease. It is known to cause neurotoxicity by various mechanisms, which are highlighted in this book. Cholinergic system impairment seems to be prominent; however, other mechanisms and pathways are also discussed and elaborated in this book. This book also covers missing aspects of the blood brain barrier and developmental toxicity, which are not very well studied areas related to Aluminium exposure alone or in combination with other metals. Knowing the pharmacokinetics of Aluminium and other metals are important aspects that can help us to understand the exposure of metals and their brain entry mechanisms, thus, opening up new horizons for the development of therapeutic options. Finally, I would say that this comprehensive book is well balanced and well written in developing understandings of basic and clinical mechanisms of Aluminium induced neurological disorders.