Editors: Surendra Nimesh, Nidhi Gupta, Ramesh Chandra

Nanomaterials: Evolution and Advancement towards Therapeutic Drug Delivery (Part II)

eBook: US $79 Special Offer (PDF + Printed Copy): US $134
Printed Copy: US $95
Library License: US $316
ISBN: 978-1-68108-824-2 (Print)
ISBN: 978-1-68108-823-5 (Online)
Year of Publication: 2021
DOI: 10.2174/97816810882351210101

Introduction

The development of a vector for the delivery of therapeutic drugs in a controlled and targeted fashion is still a major challenge in the treatment of many diseases. The conventional application of drugs may lead to many limitations including poor distribution, limited effectiveness, lack of selectivity and dose dependent toxicity. An efficient drug delivery system can address these problems. Recent nanotechnology advancements in the biomedical field have the potential to meet these challenges in developing drug delivery systems. Nanomaterials are changing the biomedical platform in terms of disease diagnosis, treatment and prevention. Nanomaterials aided drug delivery provides an advantage by enhancing aqueous solubility that leads to improved bioavailability, increased resistance time in the body, decreased side effects by targeting drugs to the specific location, reduced dose dependent toxicity and protection of drugs from early release.

In this two-part book, the contributors have compiled reports of recent studies illustrating the promising nanomaterials that can work as drug carriers which can navigate conventional physiological barriers. A detailed account of several types of nanomaterials including polymeric nanoparticles, liposomes, dendrimers, micelles, carbon nanomaterials, magnetic nanoparticles, solid lipid-based nanoparticles, silica nanomaterials and hydrogels for drug delivery is provided in separate chapters. The contributors also present a discussion on clinical aspects of ongoing research with insights towards future prospects of specific nanotechnologies.

Part II covers the following topics: · Solid lipid nanoparticles and nanostructured lipid carriers · Silica based nanomaterials · Hydrogels · Metallic nanoparticles · Computational and experimental binding interactions of drug and β-cyclodextrin · Clinical milestones in nanotherapeutics · Drug delivery systems based on poly(lactide-co-glycolide) and its copolymers

The book set is an informative resource for scholars who seek updates in nanomedicine with reference to nanomaterials used in drug delivery systems.

Foreword

- Pp. i
Prem Kumarathasan
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Preface

- Pp. ii-iii (2)
Surendra Nimesh, Nidhi Gupta and Ramesh Chandra
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List of Contributors

- Pp. iv-v (2)
Surendra Nimesh, Nidhi Gupta and Ramesh Chandra
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Solid Lipid Nanoparticles and Nanostructured Lipid Carriers for Drug Delivery Applications

- Pp. 1-56 (56)
Gabriel Silva Borges, Mariana Silva Oliveira, Délia Chaves Moreira dos Santos, Lucas Antônio Miranda Ferreira and Guilherme Carneiro*

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Silica Based Nanomaterial for Drug Delivery

- Pp. 57-89 (33)
Charu Bharti, Md. Sabir Alam, Md. Noushad Javed, Muhammed Khalid Saifullah, Faisal A. Almalki and Romila Manchanda*

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Hydrogels for Drug Delivery

- Pp. 90-124 (35)
Reena Singh, Rahul Goel, Seema Gupta* and Pradeep Kumar*

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Metallic Nanoparticles: Applications in Drug Delivery

- Pp. 125-150 (26)
Monisha Singhal, Nidhi Gupta and Jyoti Dasharath Magare*

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Computational and Experimental Binding Interactions of Drug and β-Cyclodextrin as a Drug- Delivery Vehicle

- Pp. 151-193 (43)
Chandrabose Selvaraj* and Sanjeev Kumar Singh*

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Clinical Milestones in Nanotherapeutics: Current Status and Future Prospects

- Pp. 194-245 (52)
Ravi Goyal, Rupinder K. Sodhi* and Jitender Madan

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Scale-up, Preclinical and Clinical Status of Poly (Lactide-Co-Glycolide) and its Copolymers based Drug Delivery Systems

- Pp. 246-292 (47)
Neha Bajwa, Preet Amol Singh, Kiran Jyoti, Ashish Baldi, Ramesh Chandra and Jitender Madan*

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Subject Index

- Pp. 293-303 (11)
Surendra Nimesh, Nidhi Gupta and Ramesh Chandra
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RELATED BOOKS

.Nanomaterials: Evolution and Advancement towards Therapeutic Drug Delivery (Part I).
.Biopolymers in Drug Delivery: Recent Advances and Challenges.
.Current Advances in Drug Delivery Through Fast Dissolving/Disintegrating Dosage Forms.