Chapter 5

Ring C–H Functionalization of Aromatic N-Oxides

Rafał Loska


Aromatic N-oxides occupy a central place in the synthesis of azine and azole derivatives. Unique reactivity of N-oxides makes them versatile substrates for introduction of various functional groups into the heterocyclic ring. The area of direct functionalization of C(sp2)–H bonds of aromatic N-oxides with various carbon and heteroatom substituents has seen renewed interest in recent years, resulting in introduction of several modern, versatile synthetic protocols into the arsenal of methods available within the chemistry of nitrogen heteroaromatic compounds. The aim of this review article is to provide an overview of these recent developments, together with an appropriate background in more classical N-oxide chemistry. It focuses on the most important reaction types characteristic for aromatic N-oxides, rather than the type of heterocyclic ring involved.

Total Pages: 233-295 (63)

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