Editors: Mohamed A. Imam, Martyn Snow

Bone Marrow Aspirate Concentrate and Expanded Stem Cell Applications in Orthopaedics

eBook: US $69 Special Offer (PDF + Printed Copy): US $153
Printed Copy: US $119
Library License: US $276
ISBN: 978-1-68108-650-7 (Print)
ISBN: 978-1-68108-649-1 (Online)
Year of Publication: 2018
DOI: 10.2174/97816810864911180101


This reference presents insights into the development of bone marrow aspirate stem cell (BMAC) technology and the potential role of stem cell expansion in the regeneration of damaged and deficient musculoskeletal tissues. The book features valuable contributions from stem cell therapy experts from around the world. The authors explain the production, proliferation, differentiation into various tissues, and medical applications of stem cells. In addition to work on the use of stem cells in the treatment of non-unions and bone defects, the book explores the potential for articular cartilage regeneration, repair of tendon injuries, the treatment of degenerative joint disease, revascularization of bone and regeneration of damaged nerves as well as spinal cord injury. The authors also explain ethical challenges faced by researchers and public authorities working on stem cells and the varying constraints on the development of this technology around the world.

Scientists and surgeons, alike, who are involved in the fields of orthopaedics, rheumatology, stem cell and regenerative medicine will benefit from the illuminating snapshot of the applications of BMAC stem cell expansion presented in the volume.


Mesenchymal Stem Cells in the form of expanded stem cells are believed to have multipotent plasticity. The expanded stem cells are capable of being differentiated into various cell lineages such as cartilage, bone, tendon, muscle, and nerve. These unique purported properties can play a significant role in the repair and regeneration of various tissues across a number of orthopaedic specialties.

Bone marrow is regarded as the most used source of Mesenchymal Stem Cells in orthopaedic surgery and historically many surgeons have utilised unprocessed Bone Marrow Aspirate, in attempt to stimulate healing.

The main concern in using Bone Marrow Aspirate to stimulate tissue repair/regeneration is the low concentration of stem cells found within it. To address this issue, various protocols have been developed to concentrate the nucleated cell numbers to produce Bone Marrow Aspirate Concentrate.

The concept of Bone Marrow Aspirate Concentrate is to improve the recovery of the nucleated cells from the marrow aspirate, while decreasing the recovery of non-nucleated cells such as RBCs. This book aims to examine the current reported clinical applications of bone marrow aspirate concentrate and expanded stem cells and their effectiveness in orthopaedic surgery.

Mohamed A Imam
The Royal Orthopaedic Hospital
Birmingham, B31 2AP
Suez Canal University Hospitals
Ismailia, 41111

Martyn Snow
The Royal Orthopaedic Hospital


.Stem Cells in Clinical Application and Productization.
.Stem Cell Delivery Routes: From Preclinical Models to Clinical Applications.
.The Regeneration Promise: The Facts behind Stem Cell Therapies.
.Vascularization in Tissue Engineering.