Editor: Mario D. Galigniana

Role of Molecular Chaperones in Structural Folding, Biological Functions, and Drug Interactions of Client Proteins

Volume 1

eBook: US $89 Special Offer (PDF + Printed Copy): US $163
Printed Copy: US $119
Library License: US $356
ISSN: 2589-4366 (Print)
ISSN: 2589-4374 (Online)
ISBN: 978-1-68108-616-3 (Print)
ISBN: 978-1-68108-615-6 (Online)
Year of Publication: 2018
DOI: 10.2174/97816810861561180101

Introduction

The book provides an updated panorama of the functional relevance of molecular chaperones in the proper folding of client factors, protein-protein interactions, the regulation of key biological functions, the development of ligand-based structural complexes and the consequent pharmacological or biotechnological applications of these processes. The involvement of molecular chaperones in several processes ranging from regulation of transcription factors and protein-protein interactions in bacteria to proteostasis, signaling pathways and cancer are also addressed. The book is an essential consulting tool for researchers, working professionals in academia or industry, and students of all levels who wish to obtain the most relevant and updated information currently available about protein folding and chaperones.

Contributors

Editor(s):
Mario D. Galigniana
Laboratory of Nuclear Receptors
Institute of Biology & Experimental Medicine (IBYME)
Vuelta de Obligado 2490, Buenos Aires (C1428ADN)





Contributor(s):
Taka Eguchi
Department of Radiation Oncology
Beth Israel Deaconess Medical Center, Harvard Medical School
Boston, MA 02115
Massachusetts
USA


Ben Lang
Department of Radiation Oncology
Beth Israel Deaconess Medical Center, Harvard Medical School
Boston, MA 02115
Massachusetts
USA


Ayesha Murshid
Department of Radiation Oncology
Beth Israel Deaconess Medical Center, Harvard Medical School
Boston, MA 02115
Massachusetts
USA


Thomas Prince
Department of Medicine
Boston University School of Medicine
MA 02114
Massachusetts
USA


Jianling Gong
Urologic Oncology Branch, Center for Cancer Research
National Cancer Institute
Bethesda, MD 20892
USA


Stuart K Calderwood
Department of Radiation Oncology
Beth Israel Deaconess Medical Center, Harvard Medical School
Boston, MA 02115
Massachusetts
USA


Ewa I. Gołaś
Faculty of Chemistry
University of Gdansk, Wita Stwosza 63
80-308 Gdańsk
Poland
/
Baker Laboratory of Chemistry and Chemical Biology
Cornell University
Ithaca, NY, 14853-1301
USA


Magdalena A. Mozolewska
Faculty of Chemistry
University of Gdansk, Wita Stwosza 63
80-308 Gdańsk
Poland
/
Baker Laboratory of Chemistry and Chemical Biology
Cornell University
Ithaca, NY, 14853-1301
USA


Paweł Krupa
Faculty of Chemistry
University of Gdansk, Wita Stwosza 63
80-308 Gdańsk
Poland
/
Baker Laboratory of Chemistry and Chemical Biology
Cornell University
Ithaca, NY, 14853-1301
USA


Cezary Czaplewski
Faculty of Chemistry
University of Gdansk, Wita Stwosza 63
80-308 Gdańsk
Poland


Harold A. Scheraga
Baker Laboratory of Chemistry and Chemical Biology
Cornell University
Ithaca, NY, 14853-1301
USA


Adam Liwo
Faculty of Chemistry
University of Gdansk, Wita Stwosza 63
80-308 Gdańsk
Poland


Julio C. Borges
Institute of Chemistry of Sao Carlos
University of Sao Paulo USP
São Carlos, SP, 13566-590
Brazil


Carlos H.I. Ramos
Institute of Chemistry
University of Campinas UNICAMP
Campinas SP, 13083-970
Brazil


Ana Cauerhff
Laboratorio de Biología Molecular y Celular
Departamento de Química Biológica, Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires, Consejo Nacional de Investigaciones Científicas y Técnicas
Buenos Aires
Argentina


Mario D. Galigniana
Laboratorio de Biología Molecular y Celular
Departamento de Química Biológica, Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires, Consejo Nacional de Investigaciones Científicas y Técnicas
Buenos Aires
Argentina
/
Instituto de Biología y Medicina Experimental (IBYME)-CONICET
Buenos Aires
Argentina


Victor V. Marchenkov
Institute of Protein Research
Russian Academy of Sciences, 4 Institutskaya St.
142290 Pushchino, Moscow Region
Russia


Natalia Yu Marchenko
Institute of Protein Research
Russian Academy of Sciences, 4 Institutskaya St.
142290 Pushchino, Moscow Region
Russia


Gennady V. Semisotnov
Institute of Protein Research
Russian Academy of Sciences, 4 Institutskaya St.
142290 Pushchino, Moscow Region
Russia


Rebecca L. Plimpton
Department of Chemistry and Biochemistry
Brigham Young University
Provo
Utah


José M. Valpuesta
Centro Nacional de Biotecnología
Campus de la Universidad Autónoma de Madrid
Madrid
Spain


Barry M. Willardson
Department of Chemistry and Biochemistry
Brigham Young University
Provo
Utah


Imad Baaklini
Department of Biochemistry
Groupe de Recherche Axé sur la Structure des Protéines, McGill University
Montreal
Canada


Jason C. Young
Department of Biochemistry
Groupe de Recherche Axé sur la Structure des Protéines, McGill University
Montreal
Canada


Hideaki Itoh
Department of Life Science, Graduate School and Faculty of Engineering Science
Akita University
Akita 010-8502
Japan


Tomoya Okamoto
Department of Life Science, Graduate School and Faculty of Engineering Science
Akita University
Akita 010-8502
Japan


Hiroshi Yamamoto
Department of Life Science, Graduate School and Faculty of Engineering Science
Akita University
Akita 010-8502
Japan


Ryuich Ishida
Department of Life Science, Graduate School and Faculty of Engineering Science
Akita University
Akita 010-8502
Japan




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