Editors: Andre F. Carvalho, Gislaine Zilli Reus, João Luciano de Quevedo

The Search for Antidepressants - An Integrative View of Drug Discovery

Volume 2

eBook: US $129 Special Offer (PDF + Printed Copy): US $219
Printed Copy: US $155
Library License: US $516
ISSN: 2542-7350 (Print)
ISSN: 2214-6210 (Online)
ISBN: 978-1-68108-474-9 (Print)
ISBN: 978-1-68108-473-2 (Online)
Year of Publication: 2017
DOI: 10.2174/97816810847321170201

Introduction

Major depressive disorder (MDD) is a prevalent, chronic, and recurring mental disorder. This disorder is a leading source of disability worldwide, and is associated with excess mortality rates. Currently approved antidepressants primarily enhance, or otherwise modulate monoaminergic neurotransmission, without curing the disease. Evidence indicates that only one third of patients with MDD achieve remission after treatment with a first-line antidepressant agent. Research in the past two decades has provided valuable insights into the pathophysiological understanding of MDD. However, there is an acknowledged ‘translational gap’ in the field, and few genuinely novel antidepressants have been approved for the treatment of MDD.

The Search for Anti Depressants provides readers an in-depth picture of the main pathophysiological mechanisms responsible for the development of MDD in patients. Chapters in the volume focus on possible strategies to spur the discovery of novel antidepressants. This book is an indispensable reference for mental health care providers, students at both under-graduate and graduate levels, and neuroscientists interested in the neurobiology of MDD and recent advances towards the discovery of next generation antidepressants.

Contributors

Editor(s):
Andre F. Carvalho
Associate Professor of Psychiatry
Head, Translational Psychiatry Research Group
Faculty of Medicine
Federal University of Ceara
Fortaleza, CE
Brazil


Gislaine Zilli Reus
Laboratory of Neurosciences
University of Southern Santa Catarina
1105 - Av Universitaria
Brazil


João Luciano de Quevedo
Center for Translational Psychiatry
Department of Psychiatry and Behavioral Sciences
Medical School, The University of Texas Health Science Center at Houston
Houston, TX
USA




Contributor(s):
Abir T. El-Alfy
Department of Pharmaceutical Sciences,
College of Pharmacy, Chicago State University,
Chicago, IL,
USA


Admena Rreshketa
Department of Neuroscience, Rehabilitation, Ophthalmology, Genetics, Maternal and Child Health, Section of Psychiatry
University of Genoa
Italy


Alain M. Gardier
Institut National de la Santé et de la recherche Médicale UMR-S 1178 Santé Mentale et Santé Publique, Univ. Paris-Sud, Fac Pharmacie, Université Paris Saclay
Châtenay-Malabry
France


Ana Lúcia S. Rodrigues
Department of Biochemistry, Center of Biological Sciences
Universidade Federal de Santa Catarina, Campus Universitário, Florianópolis, SC
Brazil


Andre F. Carvalho
Department of Clinical Medicine and Psychiatry Research Group
Faculty of Medicine, Federal University of Ceara, Fortaleza, CE
Brazil


Beatrice Bortolato
Department of Mental Health, ULSS 10 “Veneto Orientale”
Venice
Italy


Bijo Mathew
Department of Pharmaceutical Chemistry, Ahalia School of Pharmacy
Division of Drug Design and Medicinal Chemistry Research Lab
Palakkad, Kerala
India


Connie Sanchez
Lundbeck Research USA, Inc., 215 College Road, 07652 Paramus, NJ
United States


Daniela Felice
Univ. Paris-Sud, Fac Pharmacie, Université Paris Saclay
Institut National de la Santé et de la recherche Médicale UMR-S 1178 Santé Mentale et Santé Publique
Châtenay-Malabry
France


Denis J. David
Univ. Paris-Sud, Fac Pharmacie, Université Paris Saclay
Institut National de la Santé et de la recherche Médicale UMR-S 1178 Santé Mentale et Santé Publique
Châtenay-Malabry
France


Dominique Matthys
University of Montreal Hospital Research Center (CRCHUM); Departments of Nutrition; Neuroscience
University of Montreal



Donatella Marazziti
Dipartimento di Medicina Clinica e Sperimentale, Section of Psychiatry
University of Pisa
Pisa
Italy


Federico Mucci
Dipartimento di Medicina Clinica e Sperimentale, Section of Psychiatry
University of Pisa
Pisa
Italy


George Anderson
CRC Scotland & London, Eccleston Square
London
UK


Gerard Sanacora
Yale University School of Medicine
New Haven, CT
USA


Gianluca Serafini
Department of Neuroscience, Rehabilitation, Ophthalmology, Genetics, Maternal and Child Health, Section of Psychiatry
University of Genoa
Italy


Gislaine Z. Réus
Laboratory of Neurosciences, Graduate Program in Health Sciences, Health Sciences Unit
University of Southern Santa Catarina
Criciúma, SC
Brazil


Goutam Brahmachari
Department of Chemistry, Visva-Bharati University Santiniketan-731 235
Laboratory of Natural Products & Organic Synthesis
West Bengal
India


Helena M. Abelaira
Laboratory of Neurosciences, Graduate Program in Health Sciences, Health Sciences Unit, University of Southern Santa Catarina
Criciúma, SC
Brazil


Jane A. Foster
Department of Psychiatry & Behavioural Neurosciences @ St. Joseph's Healthcare
Hamilton


Jerad Suresh
Department of Pharmaceutical Chemistry, College of Pharmacy, Madras Medical College
Chennai
India


João Quevedo
Laboratory of Neurosciences, Graduate Program in Health Sciences, Health Sciences Unit
University of Southern Santa Catarina
Criciúma, SC
Brazil


Léa Décarie-Spain
University of Montreal Hospital Research Center (CRCHUM); Departments of Nutrition; Neuroscience
University of Montreal



Liliana Dell’Osso
Dipartimento di Medicina Clinica e Sperimentale, Section of Psychiatry
University of Pisa
Pisa
Italy


Manuela P. Kaster
Department of Biochemistry, Center of Biological Sciences
Universidade Federal de Santa Catarina, Campus Universitário
Florianópolis, SC
Brazil


Mario Amore
Department of Neuroscience, Rehabilitation, Ophthalmology, Genetics, Maternal and Child Health, Section of Psychiatry
University of Genoa
Italy


Mary Kay Lobo
Department of Anatomy and Neurobiology
Mary Kay Lobo, Assistant Professor, University of Maryland School of Medicine
Baltimore, MD
USA


Michael Maes
Deakin University, Department of Psychiatry
Geelon
Australia


Morgana Moretti
Nutrition Post-Graduate Program, Universidade Federal de Santa Catarina, Campus Universitário
Florianópolis, SC
Brazil


Paolo Girardi
Department of Neuroscience, Mental Health and Sensory Organs – Sant’Andrea Hospital
Sapienza University of Rome
Italy


Renato T. Ramos
Laboratory of Psychophysiology and Virtual Reality (LIM-23) Department of Psychiatry
Faculty of Medicine, University of São Paulo
Brazil


Roger S. McIntyre
University of Toronto, University Health Network, Mood Disorders Psychopharmacology Unit
Toronto, Ontario
Canada


Stefano Baroni
Dipartimento di Medicina Clinica e Sperimentale, Section of Psychiatry
University of Pisa
Pisa
Italy


Stephanie E. Fulton
University of Montreal Hospital Research Center (CRCHUM); Departments of Nutrition; Neuroscience, University of Montreal; Montreal Diabetes Research Centre
Montreal, QC
Canada


Yena Lee
University of Toronto, University Health Network, Mood Disorders Psychopharmacology Unit
Toronto, Ontario
Canada


Young Sup Woo
Department of Psychiatry, College of Medicine, The Catholic University of Korea, Seoul, Republic of
University of Toronto, University Health Network, Mood Disorders Psychopharmacology Unit
Toronto, Ontario
Canada




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