Editors: Andre F. Carvalho, Gislaine Zilli Reus, João Luciano de Quevedo

Series Title: Frontiers in Drug Discovery

The Search for Antidepressants - An Integrative View of Drug Discovery

Volume 2

eBook: US $129 Special Offer (PDF + Printed Copy): US $219
Printed Copy: US $155
Library License: US $516
ISSN: 2542-7350 (Print)
ISSN: 2214-6210 (Online)
ISBN: 978-1-68108-474-9 (Print)
ISBN: 978-1-68108-473-2 (Online)
Year of Publication: 2017
DOI: 10.2174/97816810847321170201


Major depressive disorder (MDD) is a prevalent, chronic, and recurring mental disorder. This disorder is a leading source of disability worldwide, and is associated with excess mortality rates. Currently approved antidepressants primarily enhance, or otherwise modulate monoaminergic neurotransmission, without curing the disease. Evidence indicates that only one third of patients with MDD achieve remission after treatment with a first-line antidepressant agent. Research in the past two decades has provided valuable insights into the pathophysiological understanding of MDD. However, there is an acknowledged ‘translational gap’ in the field, and few genuinely novel antidepressants have been approved for the treatment of MDD.

The Search for Anti Depressants provides readers an in-depth picture of the main pathophysiological mechanisms responsible for the development of MDD in patients. Chapters in the volume focus on possible strategies to spur the discovery of novel antidepressants. This book is an indispensable reference for mental health care providers, students at both under-graduate and graduate levels, and neuroscientists interested in the neurobiology of MDD and recent advances towards the discovery of next generation antidepressants.

The Search For Novel Antidepressants

- Pp. i
Andre F. Carvalho, Gislaine Z. Réus, João Quevedo
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- Pp. ii
Andre F. Carvalho, Gislaine Z. Réus, João Quevedo
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List of Contributors

- Pp. iii-iv (2)
Andre F. Carvalho, Gislaine Z. Reus, João Quevedo
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Innovative Solutions to the Development of Novel Antidepressants

- Pp. 1-40 (40)
Daniela Felice, Alain M. Gardier, Connie Sanchez, Denis J. David
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Animal Models of Depression: Current Status and Perspectives

- Pp. 41-76 (36)
Morgana Moretti, Manuela P. Kaster, Ana Lúcia S. Rodrigues
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Potential Role of Optogenetics for The Development of Novel Antidepressants

- Pp. 77-98 (22)
T. Chase Francis, Mary Kay Lobo
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The Relevance of Studies in Healthy Human Volunteers for The Development of Novel Antidepressants: Exploring Endophenotypes

- Pp. 99-125 (27)
Renato T. Ramos
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Monoamine Oxidase-A: A Valid Target for the Management of Depression

- Pp. 126-134 (9)
Bijo Mathew, Jerad Suresh
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Repurposed Drugs: A Shortcut to the Discovery of Novel Antidepressants?

- Pp. 135-176 (42)
Young Sup Woo, Yena Lee, Roger S. McIntyre
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Ketamine and Glutamatergic Compounds: Exploring Biomarkers and Mechanisms Related to Rapid Antidepressant Action

- Pp. 177-200 (24)
Gislaine Z. Réus, Helena M. Abelaira, Gerard Sanacora, João Quevedo
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Novel Antidepressant Targets for Cognitive Dysfunction in Major Depressive Disorder

- Pp. 201-221 (21)
Beatrice Bortolato, Andre F. Carvalho
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Oxidative and Nitrosative Stress, Immune Inflammation and Trptophan Catabolites in Driving Melatonergic Pathway Alterations in Depression: Treatment Implications

- Pp. 222-241 (20)
George Anderson, Michael Maes
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Novel Non-Monoaminergic Antidepressants: Focus on Neuropeptides

- Pp. 242-255 (14)
Donatella Marazziti, Federico Mucci, Stefano Baroni, Liliana Dell`Osso
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Novel Antidepressant Drugs: Exploring Neurotrophins and Intracellular Signaling Pathways

- Pp. 256-297 (42)
Gianluca Serafini, Admena Rreshketa, Maurizio Pompili, Paolo Girardi, Goutam Brahmachari, Mario Amore
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Shared Pathophysiology between Depression, Obesity and Metabolic Disturbances: Novel Antidepressant Targets?

- Pp. 298-356 (59)
Léa Décarie-Spain, Dominique Matthys, Stephanie E. Fulton
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The Development of Novel Antidepressants: Focus on Plant-based Drugs

- Pp. 357-390 (34)
Abir T. El-Alfy
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Subject Index

- Pp. 391-399 (9)
Andre F. Carvalho, Gislaine Z. Reus, João Quevedo
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