Editor: Vikas Anand Saharan

Current Advances in Drug Delivery Through Fast Dissolving/Disintegrating Dosage Forms

Personal Book: US $129 Special Offer (PDF + Printed Copy): US $219
Printed Copy: US $155
Library Book: US $516
ISBN: 978-1-68108-460-2
eISBN: 978-1-68108-459-6 (Online)
Year of Publication: 2017
DOI: 10.2174/97816810845961170101

Introduction

Fast Dissolving/Disintegrating Dosage Forms (FDDFs) have been commercially available since the late 1990s. FDDFs were initially available as orodispersible tablets, and later, as orodipsersible films for treating specific populations (pediatrics, geriatrics, and psychiatric patients). Granules, pellets and mini tablets are among latest additions to these dosage forms, which are still in the development pipeline. As drug delivery systems, FDDFs enable quicker onset of action, immediate drug delivery, and sometimes offer bioavailability benefits due to buccal/sublingual absorption. With time, FDDF have evolved to deliver drugs in a sustained and controlled manner. Their current market and application is increasing in demands with advances in age adapted dosage forms for different patients and changing regulatory requirements that warrant mandatory assessments of new drugs and drug products before commercial availability.

This book presents detailed information about FDDFs from their inception to recent developments. Readers will learn about the technical details of various FDDF manufacturing methods, formulation aspects, evaluation and methods to conduct clinical studies. The authors also give examples of marketed fast disintegrating/dissolving drug products in US, Europe, Japan, and India. This reference is ideal for pharmacology students at all levels seeking information about this specific form of drug delivery and formulation.

Preface

The solid dosage forms that dissolve or disintegrate quickly in the oral cavity, resulting in solution or suspension, eliminating the need of water for swallowing, are known as fast dissolving/disintegrating dosage forms (FDDFs). Over the last 20 years, the field of FDDFs has expanded considerably to address not only concerns of immediate release dosage forms but additionally played an important role in controlled/modified release drug delivery. This is still an exciting and growing area of pharmaceutical research and education. Ironically, to date no single book provides detailed and specific information on FDDFs. Therefore, I decided to write a book comprising of chapters that collectively address this void and provide an insight into the various technologies and methodologies currently adopted to formulate, prepare and evaluate FDDFs. The idea for this book on the topic has been in mind since my first research project during M.S.(Pharm.) at NIPER, Mohali. Since, then it gradually strengthened when I was Assistant Professor at Seth GL Bihani SD College, Sri Ganganagar and Professor/Associate Professor at Sardar Bhagwan Singh Post Graduate Institute (SBSPGI) of Biomedical Sciences & Research, Dehradun. My teaching and research in relevant and related fields continuously helped me in understanding and developing deeper interests towards FDDFs.

The present book is an attempt to provide comprehensive information to the readers interested in FDDFs. The specific emphasis in this book has been given to various technologies of making FDDFs, formulation development, evaluation, clinical studies, and marketed FDDFs products. This book intends to serve as a source of reference work and some chapters may be used for classroom teaching in graduate/postgraduate programmes. The authors do feel that graduate/postgraduate programmes in pharmaceutical sciences often neglect to adequately address FDDFs as novel drug delivery systems. Research fellows and experience scientists also feel paucity to find few resources outside the primary literature for FDDFs.

Due to its organization into different chapters, the book can be read at different levels and a reader can start as per the sequence of chapters or may opt to go directly onto the desired chapter. Thus, this book could be useful for graduate, postgraduate and PhD students belonging to the pharmaceutical sciences. Nevertheless, we do hope that this book is also useful to expert as well as new researchers, who may find information and new ideas for novel advancements in the field of FDDFs.

I hope that all those who consult this book find it useful as an easy-to-understand text for FDDFs. Constructive comments/suggestions are also invited from readers for further refinements in this book.

CONFLICT OF INTEREST

The authors confirm that they have no conflict of interest to declare for this publication.

ACKNOWLEDGEMENTS

I am grateful and highly indebted to my M.S.(Pharm.) supervisor and teacher Prof.(Dr.) Sanjay Garg for teaching the concepts of research in pharmaceutics and extending his support to this book by writing a foreword to this book. I greatly acknowledge continuous motivation and support of my Ph.D. supervisor Prof.(Dr.) P.K. Choudhury for all my efforts to do the best in the field of pharmaceutical sciences.

I am extremely grateful to the management of SBSPGI, especially Sh. S. P. Singh (Chairman, SBSPGI) and Dr. Gauravdeep Singh (Managing Secretary, SBSPGI) for all round support during my entire tenure at SBSPGI. I am highly privileged to have some of my good teachers, like Dr. Luvkush (academic advisor, SBSPGI), Prof. Veerma Ram and Ms. Urmi Chaurasia, as a constant and continuous source of inspiration and motivation.

Without the support of my mother, father and wife, it was really impossible to complete this arduous task. They have sacrificed a lot of my personal time while I was working on this book. I also missed my son, Inesh, when I was working on this book and he was not beside me.

I would like to thank all the chapter authors for their hard work, valuable contributions and their patience in various phases of publication of this book. I am extremely thankful to Bentham for providing a platform from where this book can reach to it’s readers.

Vikas A. Saharan
Department of Pharmaceutics
School of Pharmaceutical Sciences
Sardar Bhagwan Singh Post Graduate Institute
of Biomedical Sciences & Research (SBSPGI)
Balawala, Dehradun
India

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