Editors: "Manuela Lima", "Amanda Ramos", "Cristina Santos"

Genomics in Biological Anthropology: New Challenges, New Opportunities

Volume 2

Personal Book: US $39 Special Offer (PDF + Printed Copy): US $138
Printed Copy: US $119
Library Book: US $156
ISSN: 2405-7703
eISSN: 2405-7711 (Online)
ISBN: 978-1-68108-386-5
eISBN: 978-1-68108-385-8 (Online)
DOI: 10.2174/97816810838581160201

Introduction

Molecular methodologies are crucial to our understanding of human population diversity, as well as our evolutionary relationships with nonhuman primates. The completion of the Human Genome Project has given researchers a complete human reference sequence of genes. Combined with very important advances in sequencing and bioinformatics technologies, genetic research projects are now of a multidisciplinary nature. Anthropologists have the tools to seek information related to questions concerning the origin of the human species. Genomics in Biological Anthropology: New Challenges, New Opportunities explores the impact of new advances in molecular methods, such as DNA sequencing, amplification and analysis on our knowledge about the genetics of prehistoric and existing humans. Topics covered in this volume include an overview of genomic projects, mitochondrial DNA (mtDNA) analysis, ancient DNA, mutation rates in chromosome Y, genomics of isolated populations, complex phenotypes and forensic anthropology.

This volume is a concise primer for students and general readers learning the basics about human genetics, human evolution and biological anthropology.

Foreword

- Pp. i
Esther Rebato
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Preface

- Pp. ii-iii (2)
Manuela Lima, Amanda Ramos and Cristina Santos
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List of Contributors

- Pp. iv-v (2)
Manuela Lima, Amanda Ramos and Cristina Santos
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Human Genomic Projects: Setting the Stage for Genome-Scale Anthropological Studies

- Pp. 3-24 (22)
Cristina Santos, Mafalda Raposo, Amanda Ramos and Manuela Lima

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Complete Mitochondrial DNA through Massively Parallel Sequencing: Methodology and Applications

- Pp. 25-49 (25)
Sofia L. Marques, Ana Goios and Luis Alvarez

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Somatic vs Germinal Mutations in Mitochondrial DNA: Is There Any Relation with Human Health and Aging?

- Pp. 50-64 (15)
Amanda Ramos, Maria Pilar Aluja, Manuela Lima and Cristina Santos

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Human Y Chromosome Mutation Rate: Problems and Perspectives

- Pp. 65-91 (27)
Paolo Francalacci, Daria Sanna and Antonella Useli

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Genomics of Isolated Populations: Inferences for Gene-Finding Studies

- Pp. 92-105 (14)
Manuela Lima

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Complex Human Phenotypes: The Interplay between Genes and Environment

- Pp. 106-137 (32)
Mar Fatjo-Vilas and Barbara Arias

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Ancient DNA: From Single Words to Full Libraries in 30 Years

- Pp. 138-159 (22)
Marc Simon and Assumpcio Malgosa

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Troubles and Efficiency of aDNA

- Pp. 160-182 (23)
Marc Simon and Assumpcio Malgosa

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aDNA Methodological Revolution

- Pp. 183-205 (23)
Marc Simon and Assumpcio Malgosa

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Complicities Between Forensic Anthropology and Forensic Genetics: New Opportunities for Genomics?

- Pp. 206-218 (13)
Eugenia Cunha and Manuela Lima

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Subject Index

- Pp. 219-223 (5)
Manuela Lima, Amanda Ramos and Cristina Santos
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