Author: Marios Kyriazis

Series Title: Frontiers in Aging Sciences

Challenging Aging: The Anti-senescence Effects of Hormesis, Environmental Enrichment, and Information Exposure

Volume 1

eBook: US $89 Special Offer (PDF + Printed Copy): US $176
Printed Copy: US $131
Library License: US $356
ISSN: 2468-5933 (Print)
ISSN: 2468-5941 (Online)
ISBN: 978-1-68108-336-0 (Print)
ISBN: 978-1-68108-335-3 (Online)
Year of Publication: 2016
DOI: 10.2174/97816810833531160101


Age-related degeneration may be reduced or even eliminated, by positively challenging the human being, physically or cognitively, to up-regulate somatic repair functions. Exposure to meaningful information and a challenging environment act as hormetic stressors which, in the context of an increasingly technological setting, may invoke evolutionary mechanisms that lead to a persistent maintenance of homeostasis. Thus, there is a strong link between environmental factors and ongoing health, leading to an individual’s ability to continually adapt to age related challenges. Challenging Aging: The Anti-senescence Effects of Hormesis, Environmental Enrichment, and Information Exposure explains the role of hormesis in anti-aging processes followed by information on vitagenes, epigenetics, environmental enrichment and germlines. The monograph also brings newer concepts and theories to the fore, such as ‘environmental enrichment’ and ‘technoculture.’ Medical professionals and general readers, alike, will gain a a new perspective on the processes that counter aging processes in the human being.


Life is a constant struggle between the intrinsic and extrinsic challenges and the ability to counteract, defend and adapt to those challenges. This is a highly dynamic process. However, beyond the evolutionarily required “essential lifespan” (ELS), a progressive failure of homeodynamics is the fate of life, manifested in Aging and eventual death. How to prevent or slow down this failure, or how to enhance our functionality and survival, is the challenge of Aging.

Comprehensive scientific studies over the past five decades have led to the conclusion that the traditional disease-orientated biomedical model of Aging needs to be abandoned for a wholistic concept. This is because there are no specific gerontogenes or any master controller molecule(s) that cause Aging and which can be counteracted one at a time. Maintaining health, and any possible extension of lifespan, require whole-body interventions. One such approach is the phenomenon of mild stress-induced hormesis, which is the subject matter of this book.

Hormesis, hormetins and hormetics are, respectively, the phenomenon, the agents and the science of bi-phasic dose response to stressors. This is a scientific and evidence-based approach. Marios Kyriazis’ book, which also includes a contribution from another author, deals with this subject of scientific and wholistic hormesis in a most comprehensive and accessible manner.

Hormesis works. Stress of choice is good for health. Food, physical activity and psycho-social engagement are the three pillars of health. These can be personalised and optimised by using the three principles of hormesis: pleasure, moderation and variety. This book helps in opening several new practical possibilities in this regard.

Suresh Rattan
International Association of Gerontology and Geriatrics European Region – (IAGG-ER)
Aarhus University


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.A Handbook of Oral Physiology and Oral Biology.
.Comparative Bioacoustics: An Overview.