Editors: Dulce Elena Casarini, Danielle Yuri Arita, Juliana Almada Colucci, Tatiana Sousa Cunha

New Aspects of the Renin Angiotensin System in Cardiovascular and Renal Diseases

eBook: US $129 Special Offer (PDF + Printed Copy): US $219
Printed Copy: US $155
Library License: US $516
ISBN: 978-1-68108-314-8 (Print)
ISBN: 978-1-68108-313-1 (Online)
Year of Publication: 2016
DOI: 10.2174/97816810831311160101

Introduction

The renin-angiotensin system (RAS) is a hormonal system that is responsible for regulating plasma sodium ion concentration and arterial blood pressure in the body. The system involves several peptides such as angiotensin I and II as well as angiotensin converting enzyme (ACE) to enable the constriction of arterial blood vessels in the lung. Angiotensin II also stimulates the production of the hormone aldosterone in the kidneys which brings sodium ions into the bloodstream in exchange for potassium ions. Malfunctions of the RAS can lead to hypertension, heart failure, diabetes and renal complications. Thus the biochemical components of this system serve as important targets for therapeutic drugs.

This monograph is a compilation of updated reviews on the RAS. The monograph covers describes the components of the system to explaining its physiological and clinical features in the cardiovascular system and the kidneys. This is followed by sections explaining the biochemistry of the RAS system in cardiovascular and renal disease and the pharmacology of relevant therapeutic drugs. Additional information on the effect of exercise states and methods to quantify angiotensins for molecular diagnosis is also presented in the concluding sections.

Information in the monograph will be of interest to physiologists and endocrinologists involved in medical studies or clinical practice. Readers will be able to understand the RAS with a holistic frame of reference.

Contributors

Editor(s):
Dulce Elena Casarini
Department of Medicine - Nephrology Division
Escola Paulista de Medicina
Universidade Federal de São Paulo
Brazil


Danielle Yuri Arita
Department of Medicine - Nephrology Division
Escola Paulista de Medicina
Universidade Federal de São Paulo
Brazil


Juliana Almada Colucci
Department of Medicine - Nephrology Division
Escola Paulista de Medicina
Universidade Federal de São Paulo
Brazil


Tatiana Sousa Cunha
Department of Science and Technology
Escola Paulista de Medicina
Universidade Federal de São Paulo
Brazil




Contributor(s):
A.H. Jan Danser
Division of Pharmacology and Vascular Medicine
Department of Internal Medicine, Erasmus MC
Rotterdam
The Netherlands


Alexandre Costa Pereira
Laboratory of Genetic and Molecular Cardiology
Heart Institute, University of Sao Paulo
Sao Paulo
Brazil


Alexis A. Gonzalez
Instituto de Química
Pontificia Universidad Católica de Valparaíso
Chile.
/
Department of Physiology
Tulane University, School of Medicine
New Orleans
LA, USA


Allyson C. Marshall
The Hypertension & Vascular Disease Center, Department of Physiology & Pharmacology
Wake Forest University School of Medicine, Winston-Salem
North Carolina
USA


Amanda Aparecida Ribeiro
Nephrology Division, Department of Medicine, Escola Paulista de Medicina
Universidade Federal de São Paulo
Sao Paulo
Brazil


Anderson José Ferreira
Departments of Morphology, Biological Sciences Institute
Federal University of Minas Gerais, Belo Horizonte
Minas Gerais
Brazil


Andrea Sanches
Department of Physiological Sciences
Piracicaba Dental School, University of Campinas
Brazil


Andréia Cristina Febba Gomes
Nephrology Division, Department of Medicine, Escola Paulista de Medicina
Universidade Federal de São Paulo
Sao Paulo
Brazil


Bryan A. Wilson
The Hypertension & Vascular Disease Center, Department of Physiology & Pharmacology
Wake Forest University School of Medicine, Winston-Salem
North Carolina
USA


Bruno Sevá Pessôa
Nephrology Division, Department of Medicine
Escola Paulista de Medicina, Universidade Federal de São Paulo
Sao Paulo
Brazil


Candice M. Thomas
Division of Molecular Cardiology, Department of Medicine, Texas A&M Health Science Center
College of Medicine; Scott & White; Central Texas Veterans Health Care System, Temple
Texas
USA


Danielle Sanches Aragão
Nephrology Division, Department of Medicine, Escola Paulista de Medicina
Universidade Federal de São Paulo
Sao Paulo
Brazil


Danielle Yuri Arita
Nephrology Division, Department of Medicine, Escola Paulista de Medicina
Universidade Federal de São Paulo
Sao Paulo
Brazil


Debra I. Diz
The Hypertension & Vascular Disease Center, Department of Physiology & Pharmacology
Wake Forest University School of Medicine, Winston-Salem
North Carolina
USA


Dulce Elena Casarini
Nephrology Division, Department of Medicine, Escola Paulista de Medicina
Universidade Federal de São Paulo
Sao Paulo
Brazil


Ebaa Azayadneh
The Hypertension & Vascular Disease Center, Department of Physiology & Pharmacology
Wake Forest University School of Medicine, Winston-Salem
North Carolina
USA


Fernanda Aparecida Ronchi
Nephrology Division, Department of Medicine, Escola Paulista de Medicina
Universidade Federal de São Paulo
Sao Paulo
Brazil


Fernanda Barrinha Fernandes
Nephrology Division, Department of Medicine, Escola Paulista de Medicina
Universidade Federal de São Paulo
Sao Paulo
Brazil


Fernanda Klein Marcondes
Department of Physiological Sciences, Escola de Odontologia de Piracicaba
University of Campinas
Brazil


Fernanda Rezende
University of Mogi das Cruzes
Sao Paulo
Brazil


Flavia F. Jung
Washington Hospital
Washington DC
USA


Hossam A. Shaltout
The Hypertension & Vascular Disease Center, Department of Physiology & Pharmacology
Wake Forest University School of Medicine, Winston-Salem
North Carolina
USA


Ingrid Kazue Mizuno Watanabe
Nephrology Division, Department of Medicine, Escola Paulista de Medicina
Universidade Federal de São Paulo
Sao Paulo
Brazil


Isabela Bezerra Loyola
Nephrology Division, Department of Medicine, Escola Paulista de Medicina
Universidade Federal de São Paulo
Sao Paulo
Brazil


Ivana Cynthia Moraes Silva
University of Sao Paulo, Medical School
Heart Institute, Hypertension Unit
Sao Paulo
Brazil


James C. Rose
The Hypertension & Vascular Disease Center, Department of Physiology & Pharmacology
Wake Forest University School of Medicine, Winston-Salem
North Carolina
USA


Janaína Barcellos Ferreira
University of Sao Paulo Medical School
Heart Institute, Hypertension Unit
Sao Paulo
Brazil


Jorge Luiz Pesquero
Department of Physiology and Biophysics, Biological Sciences Institute
Federal University of Minas Gerais
Minas Gerais
Brazil


José Eduardo Krieger
Laboratory of Genetic and Molecular Cardiology
Heart Institute, University of Sao Paulo
Sao Paulo
Brazil


José Geraldo Mill
Department of Physiological Sciences
Federal University of Espírito Santo, Vitória
Espírito Santo
Brazil


Juliana Almada Colucci
Nephrology Division, Department of Medicine, Escola Paulista de Medicina
Universidade Federal de São Paulo
Sao Paulo
Brazil


Juliana Dinéia Perez Brandão
Nephrology Division, Department of Medicine, Escola Paulista de Medicina
Universidade Federal de São Paulo
Sao Paulo
Brazil


Kátia Bilhar Scapini
University of Sao Paulo, Medical School
Heart Institute, Hypertension Unit
Sao Paulo
Brazil


Kátia De Angelis
Nove de Julho University
Sao Paulo
Brazil


Kenneth M. Baker
Division of Molecular Cardiology, Department of Medicine
Texas A&M Health Science Center, College of Medicine; Scott & White; Central Texas Veterans Health Care System, Temple
Texas
USA


Kleiton Augusto dos Santos
Nephrology Division, Department of Medicine, Escola Paulista de Medicina
Universidade Federal de São Paulo
Sao Paulo
Brazil


L. Gabriel Navar
Department of Physiology and Tulane Hypertension and Renal Center
Tulane University, School of Medicine, New Orleans
LA
USA


Larissa Emi Matsumoto
Nephrology Division, Department of Medicine, Escola Paulista de Medicina
Universidade Federal de São Paulo
Sao Paulo
Brazil


Larissa Miranda Pereira
Division of Molecular Cardiology, Department of Medicine, Texas A&M Health Science Center
College of Medicine; Scott & White; Central Texas Veterans Health Care System, Temple
Texas
USA.
/
Nephrology Division, Department of Medicine
Universidade Federal de São Paulo
Sao Paulo
Brazil


Lília Firoozmand
Science and Technology Institute
Universidade Federal de São Paulo
São José dos Campos
Brazil


Lilian dos Santos
Nephrology Division, Department of Medicine, Escola Paulista de Medicina
Universidade Federal de São Paulo
Sao Paulo
Brazil


Lilian Saemi Arita
Nephrology Division, Department of Medicine, Escola Paulista de Medicina
Universidade Federal de São Paulo
Sao Paulo
Brazil


Lisete C. Michelini
Department of Physiology, Institute of Biomedical Science
University of São Paulo
Sao Paulo
Brazil


Ludimila Forechi
Department of Physiological Sciences
Federal University of Espírito Santo
Vitória
Brazil


Lys Angela Favaroni Mendes Salgado Ribeiro
Nephrology Division, Department of Medicine, Escola Paulista de Medicina
Universidade Federal de São Paulo
Sao Paulo
Brazil


Marcelo Perim Baldo
Department of Physiological Sciences
Federal University of Espírito Santo
Vitória, Espírito Santo
Brazil


Maria Cláudia Costa Irigoyen
University of Sao Paulo Medical School
Heart Institute, Hypertension Unit
Sao Paulo
Brazil


Maria José Costa Sampaio Moura
Life Sciences Center
Pontifical Catholic University of Campinas
Brazil


Marie Doki Nogueira
Nephrology Division, Department of Medicine, Escola Paulista de Medicina
Universidade Federal de São Paulo
Sao Paulo
Brazil


Mark C. Chappell
The Hypertension & Vascular Disease Center, Department of Physiology & Pharmacology
Wake Forest University School of Medicine, Winston-Salem
North Carolina
USA


Mercia de Paula Lima
Department of Physiology and Biophysics, Biological Sciences Institute
Federal University of Minas Gerais
Brazil


Minolfa C. Prieto
Department of Physiology and Tulane Hypertension and Renal Center
Tulane University, School of Medicine, New Orleans
LA
USA


Nádia de Sousa da Cunha Bertoncello
Science and Technology Institute
Universidade Federal de São Paulo
São José dos Campos
Brazil


Nestor Schor
Nephrology Division, Department of Medicine
Escola Paulista de Medicina Universidade Federal de São Paulo
Sao Paulo
Brazil


Qian Chen Yong
Division of Molecular Cardiology, Department of Medicine, Texas A&M Health Science Center
College of Medicine; Scott & White; Central Texas Veterans Health Care System, Temple
Texas
USA


Rafaela Costa
Department of Physiological Sciences, Escola de Odontologia de Piracicaba
University of Campinas
Brazil


Rajesh Kumar
Division of Molecular Cardiology, Department of Medicine, Texas A&M Health Science Center
College of Medicine; Scott & White; Central Texas Veterans Health Care System, Temple
Texas
USA


Rebeca Caldeira Machado
Department of Physiological Sciences
Federal University of Espírito Santo, Vitória
Espírito Santo
Brazil


Roberto Mesquita Soler
Department of Urology, Escola Paulista de Medicina
Federal University of São Paulo
São Paulo
Brazil


Robson Augusto Souza dos Santos
Department of Physiology and Biophysics, Biological Sciences Institute
Federal University of Minas Gerais, Belo Horizonte
MG
Brazil


Rodolfo Mattar Rosa
Nephrology Division, Department of Medicine, Escola Paulista de Medicina
Universidade Federal de São Paulo
Sao Paulo
Brazil


Rodrigo Araújo Fraga-Silva
Institute of Bioengineering
Ecole Polytechnique Fédérale de Lausanne
Lausanne
Switzerland


Rodrigo Yokota
Nephrology Division, Department of Medicine, Escola Paulista de Medicina
Universidade Federal de São Paulo
Sao Paulo
Brazil


Rosana Inácio dos Reis
Department of Biochemistry, Biomembrane Structure Unity
University of Oxford
England
United Kingdom


Roseli Peres Moreira
Nephrology Division, Department of Medicine, Escola Paulista de Medicina
Universidade Federal de São Paulo
Sao Paulo
Brazil


Sebastião Donato Silva Jr
Department of Physiology, Institute of Biomedical Science
University of São Paulo
São Paulo
Brazil


Silvia Lacchinni
Department of Anatomy, Institute of Biomedical Science
University of Sao Paulo
Sao Paulo
Brazil


Tatiana Sousa Cunha
Science and Technology Institute
Universidade Federal de São Paulo
São José dos Campos
Brazil


Valéria Alves Fernades
Departmentof Physiology and Biophysics
Universidade Federal de São Paulo
Brazil


Vander José das Neves
School of Physical Education and Sports
University of Sao Paulo
São Paulo
Brazil


Vanessa Oliveira
Nephrology Division, Department of Medicine, Escola Paulista de Medicina
Universidade Federal de São Paulo
Sao Paulo
Brazil


Wen Chen
Division of Molecular Cardiology, Department of Medicine, Texas A&M Health Science Center
College of Medicine; Scott & White; Central Texas Veterans Health Care System, Temple
Texas
USA


Zaira Palomino Jara
Nephrology Division, Department of Medicine, Escola Paulista de Medicina
Universidade Federal de São Paulo
Sao Paulo
Brazil




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