Editor: Nahum Rosenberg

Mesenchymal Cell Activation by Biomechanical Stimulation and its Clinical Prospects

eBook: US $39 Special Offer (PDF + Printed Copy): US $90
Printed Copy: US $71
Library License: US $156
ISBN: 978-1-68108-200-4 (Print)
ISBN: 978-1-68108-199-1 (Online)
Year of Publication: 2016
DOI: 10.2174/97816810819911160101

Introduction

The electrical response of cells to mechanical stimulus is known as mechanotransduction. This monograph is a summary of the mechanotransduction in musculoskeletal cells responsible for body tissue maintenance, support, cover and movement. While mechanotransduction is similar among these cells, there are also several important differences in mechanical parameters and cellular pathways characteristic to each cell type. Therefore, readers will have the opportunity to update their knowledge about the increasing volume of information on mechanotransduction in these cells gained from current research.

The book features a primer on general aspects of cellular biomechanics and the experimental methods and equipment commonly used for investigating cellular mechanotransduction in vitro in two dimensional cultures in which cells are adherent to plastic surfaces. Characteristic mechanotransduction pathways in mesenchymal stem cells (MSCs), chondrocytes, osteoblasts and fibroblasts are described in the accompanying chapters. Finally, a description of clinical implementation of mechanical stimulation is presented with emphasis on distraction osteogenesis, involving osteoblast stimulation, and skin stretching techniques based on fibroblast stimulation.

This monograph is a useful reference for readers involved in graduate courses or basic research in cell biology and musculoskeletal physiology.

Foreword

- Pp. i
Michael Soudry
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Preface

- Pp. iii
Nahum Rosenberg
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List of Contributors

- Pp. v
Nahum Rosenberg
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Mechanics of Living Cells - General Aspects

- Pp. 3-12 (10)
Eyal Ginesin, Kamal Hamoud and Nahum Rosenberg

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Experimental Methods for Mechanical Stimulation of Cells of Mesenchymal Origin

- Pp. 13-22 (10)
Nahum Rosenberg and Reuben Haber

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Mechanical Stimulation of Mesenchymal Stem Cells

- Pp. 23-34 (12)
David Nikomarov and Nahum Rosenberg

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Bio-Mechanical Stimulation of Skin Fibroblasts

- Pp. 35-48 (14)
Yaron Har-Shai, Isaac Zilinsky, Rei Ogawa and Chenyu Huang

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Mechanotransduction in Osteoblats

- Pp. 49-57 (9)
Yaron Berkovich, Jacob Shapira and Nahum Rosenberg

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Mechanotransduction in Chondrocytes

- Pp. 59-64 (6)
Marwan Haddad, Jacob Shapira and Nahum Rosenberg

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Cellular Molecular Pathways in Distraction Osteogenesis

- Pp. 65-72 (8)
Yoav Leiser and Adi Rachmiel

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Subject Index

- Pp. 73-75 (3)
Nahum Rosenberg
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