Editors: Atta-ur-Rahman, FRS , M. Iqbal Choudhary

Anti-Angiogenesis Drug Discovery and Development

Volume 3

Personal Book: US $149 Special Offer (PDF + Printed Copy): US $253
Printed Copy: US $179
Library Book: US $596
ISSN: 2452-3240
eISSN: 2210-268X (Online)
ISBN: 978-1-68108-156-4
eISBN: 978-1-68108-155-7 (Online)
Year of Publication: 2016
DOI: 10.2174/97816810815571160301

Introduction

The inhibition of angiogenesis is an effective mechanism of slowing down tumor growth and malignancies. The process of induction or pro-angiogenesis is highly desirable for the treatment of cardiovascular diseases, wound healing disorders, etc. Efforts to understand the molecular basis, both for inhibition and induction, have yielded fascinating results.

Anti-angiogenesis Drug Discovery and Development provides an excellent compilation of well-written reviews on various aspects of the anti-angiogenesis process. These reviews have been contributed by leading practitioners in drug discovery science and highlight the major developments in this exciting field in the last two decades. The feast of these reader-friendly reviews on topics of great scientific importance – many of which are considered significant medical breakthroughs, makes this book excellent reading both for the novice as well as for expert medicinal chemists and clinicians.

This volume brings together 5 reviews on these topics:

-Beta-blockers for treating premature retinopathy

-Anti-angiogenic activity of disintegrin-based, synthetic cyclic KTS peptides

-Anti-angiogenic therapy of lung cancer

-Oral anti-angiogenic therapy for NSCLC

-Angiogenesis in hepatocellular carcinoma

Contributors

Editor(s):
Atta-ur-Rahman, FRS
Honorary Life Fellow
Kings College
University of Cambridge
UK


M. Iqbal Choudhary
H.E.J. Research Institute of Chemistry
International Center for Chemical and Biological Sciences
University of Karachi
Karachi
Pakistan




Contributor(s):
Abdulaziz Al Farsi
Staff Medical Oncologist
Juravinski Cancer Centre
Hamilton, Ontario
Canada
/
Clinical Research Fellow in Lung Cancer
Department of Oncology, McMaster University
Hamilton, Ontario
Canada


Ana C. Fernandes
Department of Oncology
Centro Hospitalar S. João
Porto
Portugal


Cezary Marcinkiewicz
Department of Bioengineering
College of Engineering, Temple University
Philadelphia, Pennsylvania
USA


Cláudia Caeiro
Department of Oncology
Centro Hospitalar S. João
Porto
Portugal


Dai-Wei Zhao
Department of Surgery
The Second Affiliated Hospital of Guiyang Medical University
3 Kang-Fu Rd., Kaili 556000
China


David Warburton
Children's Hospital Los Angeles, The Haim Saban Research Institute, Developmental Biology and Regenerative Medicine Program
Keck School of Medicine and Ostrow School of Dentistry University of Southern California
Los Angeles, CA
USA


Efrat Noy
Department of Chemistry
Bar Ilan University
Ramat-Gan
Israel


Fernanda Cury
Molecular Oncology Research Center
Barretos Cancer Hospital
Barretos, Sao Paulo
Brazil


Guang-Chun Sun
Department of Pharmacy
The Fifth People’s Hospital of Shanghai, Fudan University
801 He-Qing Rd., Shanghai 200240
China


Hanoch Senderowitz
Department of Chemistry
Bar Ilan University
Ramat-Gan
Israel


Imad R. Makhoul
Department of Neonatology, Ruth Rappaport Children’s Hospital
Rambam Health Care Campus and Rappaport Faculty of Medicine, Technion – Israel Institute of Technology
Haifa
Israel


Jehoshua Katzehendler
School of Pharmacy
Institute for Drug Research, Faculty of Medicine, Hebrew University of Jerusalem
Jerusalem
Israel


Johannes A. Eble
Institute for Physiological Chemistry and Pathobiochemistry
University of Münster
Münster
Germany


Lichun Sun
Department of Pharmacy
The Fifth People’s Hospital of Shanghai, Fudan University
801 He-Qing Rd., Shanghai 200240
China.
/
Hunan Province Cooperative Innovation Center for Molecular Target New Drug Study
Institute of Pharmacy & Pharmacology, University of South China
Hengyang, 421001
China.
/
Department of Medicine, School of Medicine
Tulane University Health Sciences Center
New Orleans, LA 70112-2699
USA


Margarida Damasceno
Department of Oncology
Centro Hospitalar S. João
Porto
Portugal


Olga Martinho
Life and Health Sciences Research Institute (ICVS)
School of Health Sciences, University of Minho
Braga
Portugal.
/
ICVS/3B’s - PT Government Associate Laboratory
Braga/Guimarães
Portugal.
/
Molecular Oncology Research Center
Barretos Cancer Hospital
Barretos, Sao Paulo
Brazil


Peter M. Ellis
Department of Oncology
McMaster University
Hamilton, Ontario
Canada


Philip Lazarovici
School of Pharmacy
Institute for Drug Research, Faculty of Medicine, Hebrew University of Jerusalem
Jerusalem
Israel


Rui M. Reis
Life and Health Sciences Research Institute (ICVS)
School of Health Sciences, University of Minho
Braga
Portugal.
/
ICVS/3B’s - PT Government Associate Laboratory
Braga/Guimarães
Portugal.
/
Molecular Oncology Research Center
Barretos Cancer Hospital
Barretos, Sao Paulo
Brazil


Tatiana Smolkin
Department of Neonatology, Ruth Rappaport Children’s Hospital
Rambam Health Care Campus and Rappaport Faculty of Medicine, Technion – Israel Institute of Technology
Haifa
Israel


Tatjana Momic
School of Pharmacy
Institute for Drug Research, Faculty of Medicine, Hebrew University of Jerusalem
Jerusalem
Israel


Vera Miranda-Gonçalves
Life and Health Sciences Research Institute (ICVS)
School of Health Sciences, University of Minho
Braga
Portugal.
/
ICVS/3B’s - PT Government Associate Laboratory
Braga/Guimarães
Portugal


Xu Yang
Department of Pharmacy
The Fifth People’s Hospital of Shanghai, Fudan University
801 He-Qing Rd., Shanghai 200240
China