Editors: Gene D. Morse, Sarah Nanzigu

Series Title: Frontiers in HIV Research

Advances in HIV Treatment: HIV Enzyme Inhibitors and Antiretroviral Therapy

Volume 1

eBook: US $39 Special Offer (PDF + Printed Copy): US $106
Printed Copy: US $87
Library License: US $156
ISSN: 2405-9862 (Print)
ISSN: 2405-9889 (Online)
ISBN: 978-1-68108-057-4 (Print)
ISBN: 978-1-68108-056-7 (Online)
Year of Publication: 2015
DOI: 10.2174/97816810805671150101

Introduction

Advances in HIV Treatment: HIV Enzyme Inhibitors and Antiretroviral Therapy presents comprehensive and updated information on drug therapies used to treat and manage HIV infection in human patients. The volume is organized in to chapters detailing respective classes of HIV Drugs including HIV entry inhibitors, reverse transcriptase inhibitors (RTIs), integrase strand inhibitors (INSTIs), and protease inhibitors (PIs). Each chapter compiles background information, pharmacology and clinical aspects such as side effects on the specific classes of drugs represented. Available data for ongoing research for new targets, including vaccines is also presented. Readers will also find a useful introduction to HIV virology and pathogenesis as well as a comparison of the availability and activity of these agents in different populations, opening a discussion on the influence of genetics and resources in curbing the HIV epidemic. Advances in HIV Treatment: HIV Enzyme Inhibitors and Antiretroviral Therapy is, therefore, a holistic resource for researchers, healthcare professionals and clinicians interested in understanding antiretroviral drugs and the management of HIV infection/AIDS. The volume is also of interest to undergraduate and graduate students undertaking specialized courses in pharmacology and HIV/AIDS management.

Foreword

- Pp. i
Charles Chiedza Maponga
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Preface

- Pp. ii
Gene D. Morse and Sarah Nanzigu
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List of Contributors

- Pp. iii
Gene D. Morse and Sarah Nanzigu
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Acknowledgements

- Pp. iv
Gene D. Morse and Sarah Nanzigu
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Introduction

- Pp. 3-22 (20)
Sarah Nanzigu, Francis Xavier Kasujja and Immaculate Nankya

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HIV-1 Entry Inhibitors

- Pp. 23-43 (21)
Joshua R. Sawyer, Charles S. Venuto and Gene D. Morse

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Reverse Transcriptase Inhibitors

- Pp. 44-61 (18)
Amy Moss, Cara Felton and Sarah Nanzigu

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Integrase Inhibitors

- Pp. 62-74 (13)
Sarah Nanzigu and Francis Xavier Kasujja

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Protease Enzyme Inhibition

- Pp. 75-96 (22)
Rebecca A. Sumner, Cindy J. Bednasz, Qing Ma and Gene D. Morse

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Pharmacogenomics and Antiretroviral Therapy: Pharmacogenomics of HIV-1 Protease Inhibitors and Non-Nucleoside Reverse Transcriptase Inhibitors - Implications for Personalized Antiretroviral Therapy

- Pp. 97-114 (18)
Qing Ma, Kevin Hsu and Gene D. Morse

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HIV Co-Treatment

- Pp. 115-135 (21)
Sarah Nanzigu, Jaran Eriksen and Pauline Byakika-Kibwika

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Demographic Influence on the Evolution of Antiretroviral Therapy (ART)

- Pp. 136-153 (18)
Sarah Nanzigu, Moses R. Kamya and Gene D. Morse

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Subject Index

- Pp. 154-160 (7)
Gene D. Morse and Sarah Nanzigu
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