Editor: Glaucia Noeli Maroso Hajj

Young Perspectives for Old Diseases

Special Offer (PDF + Printed Copy): US $123
Printed Copy: US $123
ISBN: 978-1-68108-003-1 (Print)
ISBN: 978-1-60805-992-8 (Online)
Year of Publication: 2015
DOI: 10.2174/97816080599281150101

Introduction

In this book, a great team of young neuroscientists describes the current understanding of common and rare neurodegenerative diseases, focusing on the molecular and cellular aspects of neurodegeneration and the scientific advances for possible therapeutic approaches. These experts in each area reviewed the newest scientific information available, presenting an up-to-date view of the current knowledge and offering reliable information based upon validated research. A prime reading to clinicians, students of the medical and biological areas and other people interested in neurodegenerative diseases.

Preface

Human neurodegenerative disorders produce devastating symptoms that enormously affect both patients and their relatives. The disease pathologies share specific features, such as late onset, accumulation of misfolded proteins that form aggregates in the brain and progressive degeneration of specific neuronal populations. Patients may suffer from behavioral and physical disorders, as well as severe cognitive impairments. The incidence of neurodegenerative diseases has dramatically increased with the aging of the population and although neurodegenerative diseases represent a major threat for public health, few effective treatments are currently available. In order to discover drugs to prevent and treat neurodegenerative diseases, it is imperative to decipher the genetic and molecular mechanisms that underlie the onset and development of these disorders. Despite many years of research, scientists have not yet succeeded in understanding the precise mechanisms that lead to neurodegeneration. A number of important questions remain to be answered: how do disease-associated proteins cause neuronal dysfunction and death; what underlies cell type-specific degeneration; are these diseases age-dependent; are these gender-specific; are there common pathogenic mechanisms that underlie different neurodegenerative disorders; and how can these diseases be prevented and treated? In this book we will review the most recent findings on scientific research that explored mechanisms and pathways for the diseases. We further explore how the current knowledge is being applied to improve the life of neurodegenerative disease patients.

Glaucia Noeli Maroso Hajj
International Research Center
AC Camargo Cancer Center
National Institute for Translational
Neuroscience and National
Institute of Oncogenomics (CNPq/MCT/FAPESP)
São Paulo
Brazil

Carolina Rezával
Department of Physiology
Anatomy and Genetics
University of Oxford
UK

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