Editor: Atta-ur-Rahman / Khurshid Zaman

Topics in Anti-Cancer Research

Volume 3

eBook: US $129 Special Offer (PDF + Printed Copy): US $273
Printed Copy: US $209
Library License: US $516
ISSN: 2468-5860 (Print)
ISSN: 2213-3585 (Online)
ISBN: 978-1-60805-909-6 (Print)
ISBN: 978-1-60805-908-9 (Online)
Year of Publication: 2014
DOI: 10.2174/97816080590891140301

Introduction

This is the third volume of the Patent eBook Series entitled Topics in Anti-Cancer Research. This eBook comprises updated reviews on topics relevant to modern cancer research published in the journal Recent Patents on Anti-Cancer Drug Discovery.

The comprehensive range of themes covered in this third volume will be of benefit to clinicians, scientists and R&D experts looking for new targets for the prevention of cancer and discovery of drugs for the treatment of different cancer types. Regulation of tumor cells by TRAIL receptors, development of anti- cancer drugs & immunomodulatory drugs, molecular studies of adrenocortical cancer, role of inhibitors of inosine monophosphate dehydrogenase in cancer, recent updates in glioblastoma stem cells, latest approaches for cancer gene therapy and metabolic therapy for cancer were reviewed and updated. The role of pH regulation and application of hyperthermia, thiosemicarbazone derivatives, tamoxifen-based therapies for cancer treatment andproteome-based complex therapy of tumors, calcium signaling and angiogenesis, antineoplastic role of GHRH antagonists and therapeutic applications in human tumors and clinical oncology have been extensively discussed in the light of recent innovations.

The topics covered in this third volume will be valuable for those interested in scientists interests in methods for the prevention of cancer as well its management.

Indexed in: Book Citation Index, Science Edition, Chemical Abstracts, BIOSIS Previews, EBSCO, Ulrich's Periodicals Directory.

Foreword

- Pp. i-iv (4)
Atta-ur-Rahman, Khurshid Zaman
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List of Contributors

- Pp. v-vi (2)
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Introduction

- Pp. vii
Atta-ur-Rahman, Khurshid Zaman
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TRAIL Receptor-Induced Cell Death Regulation: An Update to Our Deadly Discussion

- Pp. 3-36 (34)
Olivier Micheau, Sarah Shirley, Alexandre Morizot
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Novel Inhibitors of Inosine Monophosphate Dehydrogenase as Potential Anti-Cancer Drugs: A Patent Review (2002-2014)

- Pp. 37-102 (66)
Riccardo Petrelli, Ilaria Torquati, Krzysztof Felczak, Daniel J. Wilson, Loredana Cappellacci
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Current and Future Medical Therapy, and the Molecular Features of Adrenocortical Cancer

- Pp. 103-150 (48)
Agata Jabrocka-Hybel, Dorota Pach, Aleksandra Gilis-Januszewska, Grzegorz Sokołowski, Alicja Hubalewska-Dydejczyk
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Therapeutic Strategies Targeting Glioblastoma Stem Cells

- Pp. 151-178 (28)
Estefania Carrasco-Garcia, Nicolas Sampron, Paula Aldaz, Olatz Arrizabalaga, Jorge Villanua, Cristina Barrena, Irune Ruiz, Mariano Arrazola, Charles Lawrie, Ander Matheu
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Calcium Signaling and Angiogenesis

- Pp. 179-201 (23)
Luca Munaron
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<i>Ganoderma lucidum</i>: A Potential for Biotechnological Production of Anti-Cancer and Immunomodulatory Drugs

- Pp. 202-271 (70)
Bojana Boh
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New Gene Therapy Strategies for Cancer Treatment: A Review of Recent Patents

- Pp. 272-318 (47)
Raúl Ortiz, Consolación Melguizo, José Prados, Pablo J. Álvarez, Octavio Caba, Fernando Rodríguez-Serrano, Fidel Hita, Antonia Aránega
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Molecular Dynamic Studies Unveil Potential Mechanisms of Resistance to Imatinib in BCR-ABL Mutants

- Pp. 319-341 (23)
Tai-Sung Lee, Steven J. Potts, Maher Albitar
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Application of Hyperthermia for Cancer Treatment: Recent Patents Review

- Pp. 342-383 (42)
Paulaes I.P. Soares, Isabel M.M. Ferreira, João P.M.R. Borges
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The Na<sup>+</sup>-H<sup>+</sup> Exchanger (NHE1) in pH Regulation and Cancer

- Pp. 384-417 (34)
Stephan J. Reshkin, Rosa A. Cardone, Katrine Zeeberg, Maria R. Greco, Salvador Harguindey
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Expanding Targets for a Metabolic Therapy of Cancer: LAsparaginase

- Pp. 418-445 (28)
Daniele Covini, Maristella Maggi, Saverio Tardito, Ovidio Bussolati, Laurent R. Chiarelli, Maria V. Pasquetto, Luca Vecchia, Giovanna Valentini, Claudia Scotti
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Aryl- and Heteroaryl-Thiosemicarbazone Derivatives and Their Metal Complexes: A Template for Pharmacological Activities

- Pp. 446-483 (38)
Narayana S.H.N. Moorthy, Nuno M.F.S.A. Cerqueira, Maria J. Ramos, Pedro A. Fernandes
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Proteome-Based Anti-Tumor Cell Therapy

- Pp. 484-529 (46)
Andrey S. Bryukhovetskiy, Valeriy E. Shevchenko, Sergey V. Kovalev, Vladimir G. Polyakov, Igor S. Bryukhovetskiy, Maria V. Zhukova
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Antineoplastic Action of Growth Hormone-Releasing Hormone (GHRH) Antagonists

- Pp. 530-551 (22)
Agnieszka Siejka, Hanna Lawnicka, Gabriela Melen-Mucha, Ewelina Motylewska, Jan Komorowski, Henryk Stepien
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New Tamoxifen-based Strategies in Cancer Research

- Pp. 552-580 (29)
Claudia Rivera-Guevara, Alma Y. Vázquez-Sánchez, Javier Camacho
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Recent Advances in Anti-Telomerase Cancer Therapy

- Pp. 581-631 (51)
Apurva Agrawal, Shweta Dang, Reema Gabrani
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Author Index

- Pp. 632-633 (2)
Atta-ur-Rahman, Khurshid Zaman
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Subject Index

- Pp. 634-658 (25)
Atta-ur-Rahman, Khurshid Zaman
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