Editor: John W. Cherwonogrodzky

Ricin Toxin

Special Offer (PDF + Printed Copy): US $118
Printed Copy: US $119
ISBN: 978-1-60805-879-2 (Print)
ISBN: 978-1-60805-878-5 (Online)
Year of Publication: 2014
DOI: 10.2174/97816080587851140101

Introduction

`Ricin Toxin’ brings together a collection of in depth and cutting edge reviews that focus on the current understanding of ricin toxins. This e-book provides a historical background, innovations in detection, identification and medical countermeasures against this biothreat, and the toxin’s previous use as an anti-cancer agent.

This e-book answers various important questions such as detection of ricin in food or soil, making of humanized antibody against the toxin, novel approaches for the creation of a safe vaccine to protect first responders, exploitation of toxin`s ability to bind and penetrate cells for medical benefits, aftereffects of administering antibody against ricin to a first responder and their exposure to the toxin, neutralization of different ricin from different castor plant cultivars. Aside from learning key concepts that may be overlooked while scanning literature, the reader will benefit from gems of information scattered throughout the book.

The book comprises of five different parts. The first part covers the background of ricin from pharaohs to bioterrorists and beyond.

The second part covers the discovery of recent technologies which are very helpful for the detection of ricin in different matrices, followed by the detection of ricin in the sorption of soils, minerals,textiles, and food; soil inflatration and dust transport. The third part covers the ricin and castor plant cultivars. It also discusses the antibody therapies such as Polyclonal and monoclonal antibodies and the extraction of ricin toxin from several cultivars of the Castor Plant (Ricinus communis).

The fourth part of this e-book discusses different medical countermeasures which are very effective in enhancing the progress in the development of vaccines against ricin intoxication. This part also describes different methods employed for the improvement of anti-ricin antibodies.

The last part of this book describes the replacement and different applications of the toxin. All chapters are written by paramount experts in ricin research.

`Ricin Toxin’ is an essential reading to all medical students, biochemists and professionals involved in the field of toxicology.

Indexed in: Book Citation Index, Science Edition, BIOSIS Previews, EBSCO.

Editor’s Biography

- Pp. i
John W. Cherwonogrodzky
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Foreword

- Pp. ii
Damien C. Chong
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Preface

- Pp. iii-iv (2)
John W. Cherwonogrodzky
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List of Contributors

- Pp. v-viii (4)
John W. Cherwonogrodzky
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Ricin - From Pharaohs to Bioterrorists and Beyond

- Pp. 3-37 (35)
Martha L. Hale
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Current Technologies for the Detection of Ricin in Different Matrices

- Pp. 38-56 (19)
Xiaohua He
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Ricin: Sorption by Soils, Minerals, Textiles, and Food; Soil Infiltration and Dust Transport

- Pp. 57-85 (29)
Richard E. Zartman and William F. Jaynes
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Risk of Ricin from Commercial Castor Production in North America

- Pp. 86-97 (12)
Dick L. Auld, Calvin L. Trostle, Travis D. Miller, Xiaohua He and Robert W. Duncan
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Generic Antibody Therapy, Polyclonal and Monoclonal, on Ricin Toxin Extracted from Several Cultivars of the Castor Plant (Ricinus Communis)

- Pp. 98-109 (12)
Rayanne Hilsen, Scott J. Jager and John W. Cherwonogrodzky
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Progress in the Development of Vaccines Against Ricin Intoxication

- Pp. 110-129 (20)
Virginia I. Roxas-Duncan and Leonard A. Smith
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Improving Anti-Ricin Antibodies: Chimerization and Selection of Ricin-Resistant Hybridoma Cell Lines

- Pp. 130-144 (15)
Seth H. Pincus, Clorinda Johnson, Grace Maresh and Kejing Song
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Anti-Ricin Protective Monoclonal Antibodies

- Pp. 145-158 (14)
Wei-Gang Hu, Junfei Yin, Damon Chau, Charles C. Hu and John W. Cherwonogrodzky
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Antibody Humanization by a Single Cycle of CDR-Grafting

- Pp. 159-181 (23)
Wei-Gang Hu, Junfei Yin, Damon Chau, Charles C. Hu and John W. Cherwonogrodzky
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Discovery of an Effective Ricin Antidote: An Old Drug for a New Use

- Pp. 182-196 (15)
Junfei Yin, Michael Fung and John W. Cherwonogrodzky
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A Ricin-Like Toxoid Used to Raise Goat Anti-Ricin Antibodies

- Pp. 197-207 (11)
Donald I.H. Stewart, Erik J. Wiersma, Vadim Tsvetnitsky, Thor Borgford, Curtis Braun, Dominik Stoll, Veronica Restelli, John W. Cherwonogrodzky, Laurel M. Negrych and Charles C. Hu
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Harnessing the Destructive Power of Ricin to Fight Human Cancer

- Pp. 208-237 (30)
Maddalena de Virgilio and Bernard Degryse
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Index

- Pp. 238-254 (17)
John W. Cherwonogrodzky
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