Editors: Atta-ur-Rahman, FRS , M. Iqbal Choudhary

Anti-Angiogenesis Drug Discovery and Development

Volume 2

eBook: US $131 Special Offer (PDF + Printed Copy): US $275
Printed Copy: US $210
Library License: US $524
ISSN: 2452-3240 (Print)
ISSN: 2210-268X (Online)
ISBN: 978-1-60805-867-9 (Print)
ISBN: 978-1-60805-866-2 (Online)
Year of Publication: 2014
DOI: 10.2174/97816080586621140201

Introduction

The inhibition of angiogenesis is an effective mechanism of slowing down tumor growth and malignancies. The process of induction or pro-angiogenesis is highly desirable for the treatment of cardiovascular diseases, wound healing disorders, etc. Efforts to understand the molecular basis, both for inhibition and induction, have yielded fascinating results.

Anti-angiogenesis Drug Discovery and Development provides is an excellent compilation of well-written reviews on various aspects of the anti-angiogenesis process. These reviews have been contributed by leading practitioners in drug discovery science and highlight the major developments in this exciting field in the last two recent decades. The feast of these reader-friendly reviews on topics of great scientific importance – many of which are considered significant medical breakthroughs, makes this book excellent reading both for the novice as well as for expert medicinal chemists and clinicians.

The second volume of this ebook series covers topics including:

-Clear Cell Renal Cell Carcinoma as a Model of Pathological Angiogenesis -Discovery and Development of Antiangiogenetic Drugs in Ovarian Cancer -Anti-Angiogenic Therapy and Cardiovascular Diseases … and more.

Indexed in: Book Citation Index, Science Edition, BIOSIS Previews, EBSCO, Ulrich's Periodicals Directory.

Preface

- Pp. i-iii (3)
Atta-ur-Rahman
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List of Contributors

- Pp. iv-vi (3)
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Mechanism of Controlling Blood Vessel Growth and Development and Identification of Therapeutics Against Pathological Angiogenesis

- Pp. 3-62 (60)
Sheetal Parida and Mahitosh Mandal

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Development of In Vitro Method for Assaying Anti-Angiogenic Effect of Drugs

- Pp. 63-111 (49)
Masumi Akita
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Clear Cell Renal Cell Carcinoma as a Model of Pathological Angiogenesis: Which Actors to Target for Treatment?

- Pp. 112-131 (20)
Caroline Hilmi and Gilles Pagès

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Inhibition of Angiogenesis in Cancer Management by Antioxidants: Ascorbate and P. leucotomos

- Pp. 132-146 (15)
Neena Philips, Halyna Siomyk, Hui Jia and Harit Parakandi

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Development of Novel Anti-Cancer Strategies Based on Angiogenesis Inhibition

- Pp. 147-190 (44)
Rajiv P. Gude, Prachi Patil, Mohammad Zahid Kamran and Peeyush N. Goel

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Discovery and Development of Antiangiogenetic Drugs in Ovarian Cancer

- Pp. 191-215 (25)
Madon M. Maile, Evelyn Y. T. Wong, Daphne Suzin, Nicole E. Birrer and Richard T. Penson

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STAT3 Signaling in Cancer: Small Molecule Intervention as Therapy?

- Pp. 216-267 (52)
John S. McMurray and Jim Klostergaard

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Anti-Angiogenic Therapy and Cardiovascular Diseases: Current Strategies and Future Perspectives

- Pp. 268-308 (41)
Vasiliki K. Katsi, Costas T. Psarros, Marios G. Krokidis, Georgia D. Vamvakou, Dimitris Tousoulis, Christodoulos I. Stefanadis and Ioannis E. Kallikazaros

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Index

- Pp. 309-314 (6)
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