Editor: Michelle Prudhomme

Advances in Anticancer Agents in Medicinal Chemistry

Volume 1

eBook: US $119 Special Offer (PDF + Printed Copy): US $214
Printed Copy: US $155
Library License: US $476
ISSN: 2589-2819 (Print)
ISSN: 2214-4331 (Online)
ISBN: 978-1-60805-712-2 (Print)
ISBN: 978-1-60805-493-0 (Online)
Year of Publication: 2013
DOI: 10.2174/97816080549301130101


Advances in Anticancer Agents in Medicinal Chemistry is an exciting eBook series comprising a selection of updated articles previously published in the peer-reviewed journal Anti-Cancer Agents in Medicinal Chemistry. The first volume gathers reviews of many classes of drugs of contemporary interest for cancer therapy and is devoted to small molecules inhibitors of various proteins involved in cancer development such as Casein kinase 2 (CK2), Protein kinase B (PKB), mTOR, Hsp90, P-glycoprotein (P-gp), Kinesin spindle protein (KSP), Cyclooxygenase 2 (COX-2), Histone deacetylase enzymes (HDACs) and Topoisomerase I.

Advances in Anticancer Agents in Medicinal Chemistry will be of particular interest to readers interested in anti cancer drug therapy as the series provides additional value to scientific research by entailing an approach of bringing relevant reviews up-to-date and thus more valuable for reference purposes.

Indexed in: Book Citation Index, Science Edition, Ulrich's Periodicals Directory.


- Pp. i
William A. Denny
Download Free


- Pp. ii-iv (3)
Michelle Prudhomme
Download Free

List of Contributors

- Pp. v-vi (2)
Michelle Prudhomme
Download Free

Casein Kinase 2 (CK2) Inhibitors: Emerging Anticancer Therapeutic Agents?

- Pp. 3-42 (40)
Giorgio Cozza, Stefano Moro
View Abstract

An Update 2009 – 2012 to “Targeted Small-Molecule Inhibitors of Protein Kinase B as Anticancer Agents”

- Pp. 43-71 (29)
Ian Collins
View Abstract

Advances in mTOR inhibitors

- Pp. 72-106 (35)
Hongyu Zhou, Shile Huang
View Abstract

Recent Advances in Hsp90 Inhibitors as Antitumor Agents

- Pp. 107-183 (77)
Samir Messaoudi, Jean F. Peyrat, Jean D. Brion, Mouâd Alami
View Abstract

Recent Developments of P-gp Inhibitors

- Pp. 184-239 (56)
Sören Krawczyk, Christiane Baumert, Andreas Hilgeroth
View Abstract

Progress Review on Kinesin Spindle Protein Inhibitors as Anti- Cancer Agents

- Pp. 240-268 (29)
Yingjie Zhang, Wenfang Xu
View Abstract

Discovery of Allosteric Inhibitors of Kinesin Spindle Protein (KSP) for the Treatment of Taxane-Refractory Cancer: MK-0731 and Analogs

- Pp. 269-317 (49)
Christopher D. Cox, Robert M. Garbaccio
View Abstract

Selective Cyclooxygenase-2 Inhibitors for Malignant Glioma Therapy: Molecular Targets Beyond COX-2

- Pp. 318-353 (36)
Axel H. Schönthal
View Abstract

Histone Deacetylase Inhibitors: Their Structure, Function and Potential to Treat Cancer

- Pp. 354-425 (72)
Charles M. Marson
View Abstract

Inhibiting Topoisomerase I, an Emerging Treatment for Primary CNS Malignancies

- Pp. 426-462 (37)
Joshua P. Sasine, Niramol Savaraj, Lynn G. Feun
View Abstract


- Pp. 463-482 (20)
Michelle Prudhomme
Download Free


.The Chemistry Inside Spices & Herbs: Research and Development.
.Botanicals and Natural Bioactives: Prevention and Treatment of Diseases.
.Frontiers In Medicinal Chemistry.
.Alkaloids and Other Nitrogen-Containing Derivatives.