Editor: Michelle Prudhomme

Advances in Anticancer Agents in Medicinal Chemistry

Volume 1

eBook: US $119 Special Offer (PDF + Printed Copy): US $214
Printed Copy: US $155
Library License: US $476
ISSN: 2589-2819 (Print)
ISSN: 2214-4331 (Online)
ISBN: 978-1-60805-712-2 (Print)
ISBN: 978-1-60805-493-0 (Online)
Year of Publication: 2013
DOI: 10.2174/97816080549301130101

Introduction

Advances in Anticancer Agents in Medicinal Chemistry is an exciting eBook series comprising a selection of updated articles previously published in the peer-reviewed journal Anti-Cancer Agents in Medicinal Chemistry. The first volume gathers reviews of many classes of drugs of contemporary interest for cancer therapy and is devoted to small molecules inhibitors of various proteins involved in cancer development such as Casein kinase 2 (CK2), Protein kinase B (PKB), mTOR, Hsp90, P-glycoprotein (P-gp), Kinesin spindle protein (KSP), Cyclooxygenase 2 (COX-2), Histone deacetylase enzymes (HDACs) and Topoisomerase I.

Advances in Anticancer Agents in Medicinal Chemistry will be of particular interest to readers interested in anti cancer drug therapy as the series provides additional value to scientific research by entailing an approach of bringing relevant reviews up-to-date and thus more valuable for reference purposes.

Indexed in: Book Citation Index, Science Edition, Ulrich's Periodicals Directory.

Foreword

- Pp. i
William A. Denny
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Preface

- Pp. ii-iv (3)
Michelle Prudhomme
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List of Contributors

- Pp. v-vi (2)
Michelle Prudhomme
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Casein Kinase 2 (CK2) Inhibitors: Emerging Anticancer Therapeutic Agents?

- Pp. 3-42 (40)
Giorgio Cozza and Stefano Moro

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An Update 2009 – 2012 to “Targeted Small-Molecule Inhibitors of Protein Kinase B as Anticancer Agents”

- Pp. 43-71 (29)
Ian Collins

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Advances in mTOR inhibitors

- Pp. 72-106 (35)
Hongyu Zhou and Shile Huang

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Recent Advances in Hsp90 Inhibitors as Antitumor Agents

- Pp. 107-183 (77)
Samir Messaoudi, Jean F. Peyrat, Jean D. Brion and Mouâd Alami

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Recent Developments of P-gp Inhibitors

- Pp. 184-239 (56)
Sören Krawczyk, Christiane Baumert and Andreas Hilgeroth

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Progress Review on Kinesin Spindle Protein Inhibitors as Anti- Cancer Agents

- Pp. 240-268 (29)
Yingjie Zhang and Wenfang Xu

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Discovery of Allosteric Inhibitors of Kinesin Spindle Protein (KSP) for the Treatment of Taxane-Refractory Cancer: MK-0731 and Analogs

- Pp. 269-317 (49)
Christopher D. Cox and Robert M. Garbaccio

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Selective Cyclooxygenase-2 Inhibitors for Malignant Glioma Therapy: Molecular Targets Beyond COX-2

- Pp. 318-353 (36)
Axel H. Schönthal

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Histone Deacetylase Inhibitors: Their Structure, Function and Potential to Treat Cancer

- Pp. 354-425 (72)
Charles M. Marson

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Inhibiting Topoisomerase I, an Emerging Treatment for Primary CNS Malignancies

- Pp. 426-462 (37)
Joshua P. Sasine, Niramol Savaraj and Lynn G. Feun

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Index

- Pp. 463-482 (20)
Michelle Prudhomme
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