Editor: Xinkang Wang

Translational Animal Models in Drug Discovery and Development

eBook: US $49 Special Offer (PDF + Printed Copy): US $143
Printed Copy: US $119
Library License: US $196
ISBN: 978-1-60805-591-3 (Print)
ISBN: 978-1-60805-469-5 (Online)
Year of Publication: 2012
DOI: 10.2174/97816080546951120101

Introduction

Animal models of diseases play a pivotal role in drug discovery and development, not only for proof of the concept studies of efficacy, PK/PD relationship but also for drug safety assessment. Since considerable differences in variables exist between animal models and human models (such as genetics, physiology, anatomy, gene expression, heterogeneity of disease conditions, etc.), not all the preclinical models are able to represent the pathophysiological conditions in human diseases. Therefore, partly due to the lack of congruency between animal and human disease models, several proposed therapeutic agents in the past decades have been demonstrated to be effective in preclinical models but failed in clinical studies. This e-book focuses on animal models of diseases from a translational perspective and highlights the key advantages and limitations of each model described to facilitate drug discovery and development. A unique feature of the volume is that it contains a selection of details disease models in various therapeutic niches with significant unmet medical needs, including inflammation, neurological diseases, cardiovascular and metabolic diseases, and oncology.

This e-book is, therefore, of considerable value to researchers and clinicians involved in drug discovery and development as well as pathology.

Contributors

Editor(s):
Xinkang Wang
Agennix Incorporated
USA




Contributor(s):
Frank C. Barone
SUNY Downstate Medical Center
Brooklyn
NY
USA


Jason H.T. Bates
University of Vermont College of Medicine
Burlington
VT
USA


Andrew R. Bond
University of Bristol
Bristol
UK


Elia Breedveld
Biomedical Primate Research Centre
Rijswijk
The Netherlands


Raffaele A. Calogero
University of Turin
Turin
Italy


Fedrica Cavallo
University of Turin
Turin
Italy


Andrew Churg
University of British Columbia
Vancouver
BC
Canada


Karen L. Edelblum
University of Chicago
Chicago
IL
USA


Guido Forni
University of Turin
Turin
Italy


David Gailani
Vanderbilt University
Nashville
TN
USA


Manuela Iezzi
University of Turin
Turin
Italy


Charles G. Irvin
University of Vermont College of Medicine
Burlington
VT
USA


Michael T. Lewis
Baylor College of Medicine
Houston
TX
USA


Jie Li
SUNY Downstate Medical Center
Brooklyn
NY
USA


Christopher L. Jackson
University of Bristol
Bristol
UK


Meghann P. McManus
Vanderbilt University
Nashville
TN
USA


Piero Musiani
University of Turin
Turin
Italy


Mercedes Rincon
University of Vermont College of Medicine
Burlington
VT
USA


Daniel M. Rosenbaum
SUNY Downstate Medical Center
Brooklyn
NY
USA


Michela Spadaro
University of Turin
Turin
Italy


Michel Vierboom
Biomedical Primate Research Centre
Rijswijk
The Netherlands


Xinkang Wang
Agennix Incorporated
Princeton
NJ
USA


Joanne L. Wright
University of British Columbia
Vancouver
BC
Canada


Jin Zhou
SUNY Downstate Medical Center
Brooklyn
NY
USA




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