Editor: Xinkang Wang

Translational Animal Models in Drug Discovery and Development

eBook: US $49 Special Offer (PDF + Printed Copy): US $143
Printed Copy: US $119
Library License: US $196
ISBN: 978-1-60805-591-3 (Print)
ISBN: 978-1-60805-469-5 (Online)
Year of Publication: 2012
DOI: 10.2174/97816080546951120101

Introduction

Animal models of diseases play a pivotal role in drug discovery and development, not only for proof of the concept studies of efficacy, PK/PD relationship but also for drug safety assessment. Since considerable differences in variables exist between animal models and human models (such as genetics, physiology, anatomy, gene expression, heterogeneity of disease conditions, etc.), not all the preclinical models are able to represent the pathophysiological conditions in human diseases. Therefore, partly due to the lack of congruency between animal and human disease models, several proposed therapeutic agents in the past decades have been demonstrated to be effective in preclinical models but failed in clinical studies. This e-book focuses on animal models of diseases from a translational perspective and highlights the key advantages and limitations of each model described to facilitate drug discovery and development. A unique feature of the volume is that it contains a selection of details disease models in various therapeutic niches with significant unmet medical needs, including inflammation, neurological diseases, cardiovascular and metabolic diseases, and oncology.

This e-book is, therefore, of considerable value to researchers and clinicians involved in drug discovery and development as well as pathology.

Foreword

- Pp. i-iii (3)
Giora Feuerstein
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Preface

- Pp. iv-vii (4)
Xinkang Wang
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List of Contributors

- Pp. viii-ix (2)
Xinkang Wang
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Animal Models of Atherosclerosis and Spontaneous Plaque Rupture

- Pp. 3-23 (21)
Andrew R. Bond and Christopher L. Jackson

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Experimental Models of Heart Failure: Translational Investigation of Cardiac Drug Safety

- Pp. 24-41 (18)
Xinkang Wang

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Animal Models of Ischemic Stroke: Issues in Translational Congruency

- Pp. 42-66 (25)
Frank C. Barone, Daniel M. Rosenbaum, Jie Li, Jin Zhou and Xinkang Wang

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Mouse Models of Coagulation Factor Deficiencies for Translational Research

- Pp. 67-121 (55)
Meghann P. McManus and David Gailani

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Xenograft Models of the Normal and Malignant Human Breast

- Pp. 122-138 (17)
Michael T. Lewis
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BALB-neuT Female Mice as a Dynamic Model of Mammary Cancer

- Pp. 139-166 (28)
Manuela Iezzi, Raffaele A. Calogero, Michela Spadaro, Piero Musiani, Guido Forni and Federica Cavallo

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Modeling Human Asthma in Animals

- Pp. 167-195 (29)
Jason H.T. Bates, Mercedes Rincon and Charles G. Irvin

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Cigarette Smoke-Induced Translational Animal Models of Chronic Obstructive Lung Disease

- Pp. 196-216 (21)
Andrew Churg and Joanne L. Wright

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Mouse Models of Inflammatory Bowel Disease: Mechanistic Insight into Current and Future Therapeutics

- Pp. 217-246 (30)
Karen L. Edelblum

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In Vivo Veritas: Preclinical Models of Human Arthritic Disease in Non-Human Primates

- Pp. 247-273 (27)
Michel Vierboom and Elia Breedveld

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Index

- Pp. 274-275 (2)
Xinkang Wang
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