Editor: Xinkang Wang

Translational Animal Models in Drug Discovery and Development

eBook: US $49 Special Offer (PDF + Printed Copy): US $143
Printed Copy: US $119
Library License: US $196
ISBN: 978-1-60805-591-3 (Print)
ISBN: 978-1-60805-469-5 (Online)
Year of Publication: 2012
DOI: 10.2174/97816080546951120101

Introduction

Animal models of diseases play a pivotal role in drug discovery and development, not only for proof of the concept studies of efficacy, PK/PD relationship but also for drug safety assessment. Since considerable differences in variables exist between animal models and human models (such as genetics, physiology, anatomy, gene expression, heterogeneity of disease conditions, etc.), not all the preclinical models are able to represent the pathophysiological conditions in human diseases. Therefore, partly due to the lack of congruency between animal and human disease models, several proposed therapeutic agents in the past decades have been demonstrated to be effective in preclinical models but failed in clinical studies. This e-book focuses on animal models of diseases from a translational perspective and highlights the key advantages and limitations of each model described to facilitate drug discovery and development. A unique feature of the volume is that it contains a selection of details disease models in various therapeutic niches with significant unmet medical needs, including inflammation, neurological diseases, cardiovascular and metabolic diseases, and oncology.

This e-book is, therefore, of considerable value to researchers and clinicians involved in drug discovery and development as well as pathology.

Foreword

- Pp. i-iii (3)
Giora Feuerstein
Download Free

Preface

- Pp. iv-vii (4)
Xinkang Wang
Download Free

List of Contributors

- Pp. viii-ix (2)
Xinkang Wang
Download Free

Animal Models of Atherosclerosis and Spontaneous Plaque Rupture

- Pp. 3-23 (21)
Andrew R. Bond, Christopher L. Jackson
View Abstract

Experimental Models of Heart Failure: Translational Investigation of Cardiac Drug Safety

- Pp. 24-41 (18)
Xinkang Wang
View Abstract

Animal Models of Ischemic Stroke: Issues in Translational Congruency

- Pp. 42-66 (25)
Frank C. Barone, Daniel M. Rosenbaum, Jie Li, Jin Zhou, Xinkang Wang
View Abstract

Mouse Models of Coagulation Factor Deficiencies for Translational Research

- Pp. 67-121 (55)
Meghann P. McManus, David Gailani
View Abstract

Xenograft Models of the Normal and Malignant Human Breast

- Pp. 122-138 (17)
Michael T. Lewis
View Abstract

BALB-neuT Female Mice as a Dynamic Model of Mammary Cancer

- Pp. 139-166 (28)
Manuela Iezzi, Raffaele A. Calogero, Michela Spadaro, Piero Musiani, Guido Forni, Federica Cavallo
View Abstract

Modeling Human Asthma in Animals

- Pp. 167-195 (29)
Jason H.T. Bates, Mercedes Rincon, Charles G. Irvin
View Abstract

Cigarette Smoke-Induced Translational Animal Models of Chronic Obstructive Lung Disease

- Pp. 196-216 (21)
Andrew Churg, Joanne L. Wright
View Abstract

Mouse Models of Inflammatory Bowel Disease: Mechanistic Insight into Current and Future Therapeutics

- Pp. 217-246 (30)
Karen L. Edelblum
View Abstract

In Vivo Veritas: Preclinical Models of Human Arthritic Disease in Non-Human Primates

- Pp. 247-273 (27)
Michel Vierboom, Elia Breedveld
View Abstract

Index

- Pp. 274-275 (2)
Xinkang Wang
Download Free

RELATED BOOKS

.Key Heterocyclic Cores for Smart Anticancer Drug–Design Part II.
.Key Heterocyclic Cores for Smart Anticancer Drug–Design Part I.
.Frontiers in Cardiovascular Drug Discovery.
.Frontiers in Drug Design and Discovery.