Sialobiology: Structure, Biosynthesis and Function Sialic Acid Glycoconjugates in Health and Disease

by

Joe Tiralongo, Ivan Martinez-Duncker

DOI: 10.2174/97816080538651130101
eISBN: 978-1-60805-386-5, 2013
ISBN: 978-1-60805-067-3



Indexed in: Book Citation Index, Science Edition, BIOSIS Previews, Scopus, EBSCO.

This eBook presents a summary of central aspects of sialobiology (i.e., the study of sialic acid and its relevance to biology). The im...[view complete introduction]
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Sialic Acid Recognition, Removal and Surface Presentation: Role in Microbial Pathogenesis of Human Hosts

- Pp. 236-274 (39)

Christopher J. Day and Joe Tiralongo

Abstract

Sialic acids (Sia) play a role in the survival of microbes within the diverse environments that both pathogenic and non-pathogenic microbes inhabit. 3-Deoxy-Dmanno- oct-2-ulosonic acid (KDO) and 2-keto-3-deoxynononic acid (KDN) are crucial for the survival of almost all bacterial species, while other Sia are a favourite target for viruses and other host adapted pathogens when interacting with host tissues that are required for survival/replication of the microbe. All pathogenic microbes, whether bacteria, viruses, parasites, or fungi, must be able to specifically interact with host cells/tissues to initiate disease. The success of these pathogens at maintaining a disease state relies on the ability of these organisms to subvert or evade the host immune responses. In this chapter we will discuss the ways in which Sia, Neu5Ac specifically, is crucial for the ability for many human pathogens to cause and maintain disease.

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