Editors: Joe Tiralongo, Ivan Martinez-Duncker

Sialobiology: Structure, Biosynthesis and Function Sialic Acid Glycoconjugates in Health and Disease

eBook: US $89 Special Offer (PDF + Printed Copy): US $250
Printed Copy: US $206
Library License: US $356
ISBN: 978-1-60805-067-3 (Print)
ISBN: 978-1-60805-386-5 (Online)
Year of Publication: 2013
DOI: 10.2174/97816080538651130101

Introduction

This eBook presents a summary of central aspects of sialobiology (i.e., the study of sialic acid and its relevance to biology). The importance of substitution by the sugar sialic acid and the role played by sialylated structures (eg. glycoproteins, glycolipids, glycoconjugates) in immune recognition, neural cell growth, embryogenesis and disease development including microbial pathogenesis and cancer progression, has become well-established.

Since 1995, the field of sialobiology has expanded greatly as many of the key enzymes involved in sialic acid biosynthesis, as well as the vast majority of sialic acid binding lectins involved in immune recognition, have only been cloned, characterised and structural eluciated after the publication of earlier works on the subject. This e-book also covers these recent developments. Chapters in this e-book have been contributed by eminent sialobiologists. Therefore, a book of this nature is timely and will prove to be a definitive volume with a high impact in this field for glycobiologists and cell biologists.

Foreword

- Pp. i- (1)
Mark von Itzstein
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Preface

- Pp. ii-iv (3)
Joe Tiralongo and Ivan Martinez-Duncker
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List of Contributors

- Pp. v-viii (4)
Joe Tiralongo and Ivan Martinez-Duncker
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Introduction to Sialic Acid Structure, Occurrence, Biosynthesis and Function

- Pp. 3-32 (30)
Joe Tiralongo

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Polysialic Acid

- Pp. 33-75 (43)
Chihiro Sato

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Sialic Acid Biosynthesis in Vertebrates

- Pp. 76-114 (39)
Anja K. Münster-Kühnel and Stephan Hinderlich

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CMP-Sialic Acid Transporter

- Pp. 115-138 (24)
Andrea Maggioni, Ivan Martinez-Duncker and Joe Tiralongo

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Vertebrate Sialyltransferases

- Pp. 139-187 (49)
Anne Harduin-Lepers

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Mammalian Sialidases

- Pp. 188-208 (21)
Tadashi Suzuki and Kazunori Yamaguchi

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Bacterial Sialate O-Acetyltransferases

- Pp. 209-235 (27)
Martina Mühlenhoff and Anne K. Bergfeld

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Sialic Acid Recognition, Removal and Surface Presentation: Role in Microbial Pathogenesis of Human Hosts

- Pp. 236-274 (39)
Christopher J. Day and Joe Tiralongo

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Milk Sialooligosacharides: Biological Implications and Purification Strategies

- Pp. 275-312 (38)
Ulrike Hubl and Eduard Nekrasov

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Gangliosides

- Pp. 313-380 (68)
Eduard Nekrasov and Ulrike Hubl
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Sialic Acids and Cancer

- Pp. 381-403 (23)
Alexandre S. Stephens, Christopher J. Day and Joe Tiralongo

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Synthesis of Sialic Acid-Containing Oligosaccharides and Sialylmimetics

- Pp. 404-447 (44)
Sadagopan Magesh and Hiromune Ando

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Advances in Sialic Acid and Polysialic Acid Detection Methodologies

- Pp. 448-475 (28)
Sebastian P. Galuska

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Metabolic Glycoengineering of Sialic Acids

- Pp. 476-511 (36)
Jian Du, Ruben T. Almaraz, Elaine Tan and Kevin J. Yarema

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Index

- Pp. 512-520 (9)
Joe Tiralongo and Ivan Martinez-Duncker
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