Editor: Guangpu Li

Rab GTPases and Membrane Trafficking

eBook: US $79 Special Offer (PDF + Printed Copy): US $158
Printed Copy: US $119
Library License: US $316
ISBN: 978-1-60805-391-9 (Print)
ISBN: 978-1-60805-365-0 (Online)
Year of Publication: 2012
DOI: 10.2174/97816080536501120101

Introduction

Ypt/Rab GTPases form the largest branch of the Ras-related small GTPase superfamily and regulate intracellular membrane trafficking in all eukaryotes. Since their discovery over two decades ago, a wealth of information has accumulated about the roles that Ypt/Rab proteins play in vesicular transport steps, including vesicle budding, movement, and fusion. In recent years, Ypt/Rab GTPases and membrane trafficking have been discovered to play an important role in other cellular processes, such as signal transduction, cell growth and differentiation. Additionally, Rab GTPases have been implicated in various human diseases, ranging from diabetes to cancer. This e-book provides a timely update on the rapidly developing field and discusses all functional aspects of Ypt/Rab GTPases. The 12 chapters cover well-characterized Ypts/Rabs involved in both exocytic and endocytic pathways as well as newly identified and uncharacterized Rab GTPases. A comprehensive picture about how each Ypt/Rab controls multiple vesicular trafficking steps via interactions with multiple effectors is conveyed to the reader’s mind.

This e-book is the first ever volume focused on the Ypt/Rab GTPases and should provide a useful resource for researchers, students and teachers interested in the field.

Indexed in: BIOSIS Previews, Chemical Abstracts, Scopus, EBSCO.

Contributors

Editor(s):
Guangpu Li
The University of Oklahoma Health Sciences Center
USA
/
The University of Illinois at Chicago
USA




Contributor(s):
Anna Akhmanova
Department of Biology
Utrecht University
The Netherlands


Margarita Cabrera
Department of Biology/Chemistry
University of Osnabrück
Barbarastrasse 13
Osnabrück, 49076
Germany


Shu H. Chen
Department of Biological Sciences
University of Illinois at Chicago
Chicago
IL, 60607
USA


François Darchen
CNRS/Université Paris Descartes UMR 8192
Centre Universitaire des Saints-Pères
47 rue des Saints-Pères
Paris, 75006
France


Magda Deneka
Department of Cell Biology
University Medical Center Utrecht
Utrecht
GA, 3508
The Netherlands


Claire Desnos
CNRS/Université Paris Descartes UMR 8192
Centre Universitaire des Saints-Pères
47 rue des Saints-Pères
Paris, 75006
France


Eric J. Espinosa
Department of Biochemistry
Stanford University School of Medicine
Stanford
CA, 94305-5307
USA


Vishnu Ganesan
Department of Biology
University of Pennsylvania
Philadelphia
PA, 19104-6018
USA


James R. Goldenring
Departments of Surgery and Cell and Developmental Biology Epithelial Biology Center
Vanderbilt University School of Medicine
2213 Garland Ave
Nashville
TN, 37232-2733
USA


Bruno Goud
Institut Curie
CNRS UMR144
26 rue d'Ulm
Paris cedex 05, 75248
France


Wei Guo
Department of Biology
University of Pennsylvania
Philadelphia
PA, 19104-6018
USA


John A. Hammer
Laboratory of Cell Biology
National Heart, Lung and Blood Institute
National Institutes of Health
Bethesda
MD, 20824
USA


Andreas Knödler
Department of Biology
University of Pennsylvania
Philadelphia
PA, 19104-6018
USA


Lynne A. Lapierre
Departments of Surgery and Cell and Developmental Biology Epithelial Biology Center
Vanderbilt University School of Medicine
2213 Garland Ave
Nashville
TN, 37232-2733
USA


Guangpu Li
Department of Biochemistry and Molecular Biology
University of Oklahoma Health Sciences Center
Oklahoma City
OK, 73104
USA


Mirjana Nordmann
Department of Biology/Chemistry
University of Osnabrück
Barbarastrasse 13
Osnabrück, 49076
Germany


José B. Pereira-Leal
Instituto Gulbenkian de Ciência
Rua da Quinta Grande 6
Portugal


Suzanne R. Pfeffer
Department of Biochemistry
Stanford University School of Medicine
Stanford
CA, 94305-5307
USA


Ioana Popa
Department of Cell Biology
University Medical Center Utrecht
Utrecht
GA, 3508
The Netherlands


Maria Luisa Rodrigues
Instituto Gulbenkian de Ciência
Rua da Quinta Grande 6
Portugal


Joseph T. Roland
Departments of Surgery and Cell and Developmental Biology Epithelial Biology Center
Vanderbilt University School of Medicine
2213 Garland Ave
Nashville
TN, 37232-2733
USA


Emma Martinez Sanchez
Department of Cell Biology
University Medical Center Utrecht
Utrecht
GA, 3508
The Netherlands


Nava Segev
Department of Biochemistry and Molecular Genetics
University of Illinois at Chicago
Chicago
IL, 60607
USA


Peter van der Sluijs
Department of Cell Biology
University Medical Center Utrecht
Utrecht
GA, 3508
The Netherlands


David Taussig
Department of Biological Sciences
University of Illinois at Chicago
Chicago
IL, 60607
USA


Christian Ungermann
Department of Biology/Chemistry
University of Osnabrück
Barbarastrasse 13
Osnabrück, 49076
Germany


Xufeng Wu
Laboratory of Cell Biology
National Heart, Lung and Blood Institute
National Institutes of Health
Bethesda
MD, 20824
USA




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