Editor: Guangpu Li

Rab GTPases and Membrane Trafficking

eBook: US $79 Special Offer (PDF + Printed Copy): US $158
Printed Copy: US $119
Library License: US $316
ISBN: 978-1-60805-391-9 (Print)
ISBN: 978-1-60805-365-0 (Online)
Year of Publication: 2012
DOI: 10.2174/97816080536501120101

Introduction

Ypt/Rab GTPases form the largest branch of the Ras-related small GTPase superfamily and regulate intracellular membrane trafficking in all eukaryotes. Since their discovery over two decades ago, a wealth of information has accumulated about the roles that Ypt/Rab proteins play in vesicular transport steps, including vesicle budding, movement, and fusion. In recent years, Ypt/Rab GTPases and membrane trafficking have been discovered to play an important role in other cellular processes, such as signal transduction, cell growth and differentiation. Additionally, Rab GTPases have been implicated in various human diseases, ranging from diabetes to cancer. This e-book provides a timely update on the rapidly developing field and discusses all functional aspects of Ypt/Rab GTPases. The 12 chapters cover well-characterized Ypts/Rabs involved in both exocytic and endocytic pathways as well as newly identified and uncharacterized Rab GTPases. A comprehensive picture about how each Ypt/Rab controls multiple vesicular trafficking steps via interactions with multiple effectors is conveyed to the reader’s mind.

This e-book is the first ever volume focused on the Ypt/Rab GTPases and should provide a useful resource for researchers, students and teachers interested in the field.

Indexed in: BIOSIS Previews, Chemical Abstracts, Scopus, EBSCO.

Foreword

- Pp. i
Philip D. Stahl
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Preface

- Pp. ii
Guangpu Li and Nava Segev
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List of Contributors

- Pp. iii-vi (4)
Guangpu Li and Nava Segev
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Ypt/Rab GTPases and Intracellular Membrane Trafficking: An Overview

- Pp. 3-17 (15)
Guangpu Li and Nava Segev

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The Golgi Gatekeepers: Ypt1-Rab1 and Ypt31/32-Rab11

- Pp. 18-33 (16)
David Taussig, Shu H. Chen and Nava Segev

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Rab6 GTPase

- Pp. 34-46 (13)
Bruno Goud and Anna Akhmanova

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Polarized Exocytosis in Yeast: Sec4p

- Pp. 47-54 (8)
Andreas Knödler, Vishnu Ganesan and Wei Guo

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Masterclass with Rab3 and Rab27: Orchestrating Regulated Secretion

- Pp. 55-76 (22)
François Darchen and Claire Desnos
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Functions of Rab27a in Melanocytes and Cytotoxic T Lymphocytes

- Pp. 77-92 (16)
John A. Hammer III and Xufeng Wu

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Early Endocytosis: Rab5, Rab21, and Rab22

- Pp. 93-107 (15)
Guangpu Li

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Role of Rab4 in Transport through the Endosomal System

- Pp. 108-122 (15)
Emma Martinez Sanchez, Ioana Popa, Magda Deneka and Peter van der Sluijs

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Rab11a, Rab8a and Myosin V: Regulators of Recycling and Beyond

- Pp. 123-131 (9)
James R. Goldenring, Joseph T. Roland and Lynne A. Lapierre

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Role of Rab7/Ypt7 in Organizing Membrane Trafficking at the Late Endosome

- Pp. 132-143 (12)
Mirjana Nordmann, Christian Ungermann and Margarita Cabrera

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Transport from Late Endosomes to the Golgi: Rab9 GTPase

- Pp. 144-154 (11)
Eric J. Espinosa and Suzanne R. Pfeffer

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Novel Rab GTPases

- Pp. 155-168 (14)
Maria Luisa Rodrigues and José B. Pereira-Leal

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Index

- Pp. 169-172 (4)
Guangpu Li and Nava Segev
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