Editors: Klaus Podar, Kenneth C. Anderson

Multiple Myeloma - A New Era of Treatment Strategies

eBook: US $29 Special Offer (PDF + Printed Copy): US $133
Printed Copy: US $119
Library License: US $116
ISBN: 978-1-60805-609-5 (Print)
ISBN: 978-1-60805-297-4 (Online)
Year of Publication: 2012
DOI: 10.2174/97816080529741120101

Introduction

Multiple Myeloma (MM), the second most common blood cancer in adults, is a clonal plasma cell malignancy within the bone marrow characterized by osteolytic bone lesions, renal disease, and immunodeficiency. It is now well established that MM cell- induced disruption of the bone marrow homeostasis between the highly organized cellular and extracellular compartments supports MM cell proliferation, survival, migration, and drug resistance via activation of various signaling pathways. Based on this knowledge, the prototypic drugs thalidomide, bortezomib, and lenalidomide, which target both MM cells and the bone marrow microenvironment, have already fundamentally changed treatment options of this disease. Indeed, their benefit is now not only shown in relapsed and refractory disease but they also improve overall response, duration of response, and progression-free and overall survival when used as part of first-line regimens. However, despite new insights into MM pathogenesis and exciting derived therapeutic advances, MM still remains incurable. Ongoing studies are therefore aiming to further delineate mechanisms of MM pathogenesis within the bone marrow to identify novel agents with enhanced cytotoxicity and decreased drug resistance to improve patient outcome.

Multiple Myeloma - A New Era of Treatment Strategies is devoted to contributions from eminent scientists providing readers with comprehensive accounts of the most recent developments in the field of MM research. It addresses the interests of scientists and clinical investigators in MM research as well as other fields of oncology, in which the microenvironment is believed to play an important role.

Indexed in: Book Citation Index, Science Edition, Web of Science, Scopus, EBSCO.

Foreword

- Pp. i
S. Vincent Rajkumar
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Preface

- Pp. ii-iii (2)
Klaus Podar and Kenneth C. Anderson
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List of Contributors

- Pp. iv-vi (3)
Klaus Podar and Kenneth C. Anderson
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A Short History of Multiple Myeloma

- Pp. 3-14 (12)
Robert A. Kyle and David P. Steensma

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Epidemiology and Etiology of Multiple Myeloma

- Pp. 15-57 (43)
Brenda M. Birmann, Brian C.-H. Chiu, Kristin Muench, Catherine A. Suppan and Wendy Cozen

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Genetic and Epigenetic Mechanisms in Multiple Myeloma

- Pp. 58-72 (15)
Michela Frenquelli and Giovanni Tonon

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Guideline to Multiple Myeloma Treatment Strategies

- Pp. 73-87 (15)
Klaus Podar, Jonathan L. Kaufmann, Jacob P. Laubach, Sagar Lonial, Paul G. Richardson and Kenneth C. Anderson

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The Role of Stem Cell Transplantation in Multiple Myeloma

- Pp. 88-96 (9)
Jean-Luc Harousseau

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Pathogenesis and Treatment of Bone Disease in Multiple Myeloma

- Pp. 97-106 (10)
Sonia Vallet and Noopur Raje

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Management of Complications in Multiple Myeloma

- Pp. 107-119 (13)
Suzanne Lentzsch

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Promising Clinical Trials in Multiple Myeloma

- Pp. 120-127 (8)
Shaji Kumar

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The Multiple Myeloma Bone Marrow Microenvironment

- Pp. 128-137 (10)
Aldo M. Roccaro, Angelo Vacca, Giuseppe Rossi and Irene Ghobrial

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Multiple Myeloma Bone Marrow Angiogenesis

- Pp. 138-148 (11)
Domenico Ribatti and Angelo Vacca

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Mouse Models of Multiple Myeloma: Advantages and Pitfalls

- Pp. 149-160 (12)
Mariateresa Fulciniti, Paola Neri, Pierosandro Tagliaferri and Pierfrancesco Tassone

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New Therapeutic Strategies in Multiple Myeloma

- Pp. 161-183 (23)
Klaus Podar, Teru Hideshima, Dharminder Chauhan and Kenneth C. Anderson

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Antibody-based Therapies in Multiple Myeloma

- Pp. 184-199 (16)
Yu-Tzu Tai

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Index

- Pp. 200-204 (5)
Klaus Podar and Kenneth C. Anderson
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