Editors: Alessandra Pagliarani, Fabiana Trombetti, Vittoria Ventrella

Biochemical and Biological Effects of Organotins

eBook: US $44 Special Offer (PDF + Printed Copy): US $141
Printed Copy: US $119
Library License: US $176
ISBN: 978-1-60805-367-4 (Print)
ISBN: 978-1-60805-265-3 (Online)
Year of Publication: 2012
DOI: 10.2174/97816080526531120101


Organotins are widespread contaminants especially of water environments. Their chemically versatile structure makes organotin compounds able to bind to a variety of biomolecules thus widely affecting biological functions. Trisubstituted molecules, namely tributyltin (TBT) and triphenyltin (TPhT), have been widely employed in antifouling paints and are also exploited as plastic stabilizers that unfortunately cause harmful biological effects. Persistent bioaccumulation has resulted in organotins becoming a significant environmental threat. Chapter by chapter, the biological and biochemical effects of organotins are unravelled in this e-book by a careful analysis of the most recent findings with special focus on contaminant action mechanisms at cellular and molecular level. The e-book provides an intriguing insight into the molecular mechanisms involved in organotin toxicology thus serving as a useful reference to biochemists, biologists, ecotoxicologists and life science students.

Indexed in: Book Citation Index, Science Edition, BIOSIS Previews, Chemical Abstracts, Scopus, EBSCO.


- Pp. i
Giorgio Lenaz
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- Pp. ii-iii (2)
Alessandra Pagliarani, Fabiana Trombetti, Vittoria Ventrella
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List of Contributors

- Pp. iv-vi (3)
Alessandra Pagliarani, Fabiana Trombetti, Vittoria Ventrella
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Abbreviations of Organotin Compounds

- Pp. vii-viii (2)
Alessandra Pagliarani, Fabiana Trombetti, Vittoria Ventrella
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Ecotoxicological Impacts of Organotins: An Overview

- Pp. 3-24 (22)
Toshihiro Horiguchi
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Biological Activity of Organotin(IV) Compounds: Structural and Chemical Aspects

- Pp. 25-52 (28)
Laszlo Nagy, Claudia Pellerito, Lorenzo Pellerito
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Covalent Interactions of Organotins with Nuclear Receptors

- Pp. 53-69 (17)
Felix Grun
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Biomembrane Perturbation Induced by Organotin in Model and Biological Membranes

- Pp. 70-74 (5)
Giancarlo Falcioni
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Organotins as Endocrine Disruptors: An Examination of Tributyltin-Induced Imposex in Neogastropods

- Pp. 75-82 (8)
Robin M Sternberg
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Lipid Homeostasis Perturbation by Organotins: Effects on Vertebrates and Invertebrates

- Pp. 83-96 (14)
Miguel Machado Santos, Maria Armanda Reis-Henriques, Luis Filipe Costa Castro
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Genotoxicity and Immunotoxicity of Organotins

- Pp. 97-111 (15)
Francesca Cima, Loriano Ballarin
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Organotins as Mitochondrial Toxins

- Pp. 112-124 (13)
Sabrina Manente, Alessandra Iero, Marcantonio Bragadin
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Organotins and Hydromineral Homeostasis in Aquatic Animals

- Pp. 125-148 (24)
Mark G.J. Hartl
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Mechanisms of Organotin-Induced Apoptosis

- Pp. 149-163 (15)
Zeljko Jaksic
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Organotins and Humans: Threat and Risk

- Pp. 164-173 (10)
Asha Giriyan, Sangeeta Sonak
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Organotin Effects in Different Phyla: Discrepancies and Similarities

- Pp. 174-196 (23)
Alessandra Pagliarani, Salvatore Nesci, Fabiana Trombetti, Vittoria Ventrella
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- Pp. 197-204 (8)
Alessandra Pagliarani, Fabiana Trombetti, Vittoria Ventrella
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