Editor: Adit B.-Baruch

The Inflammatory Milieu of Tumors: Cytokines and Chemokines that Affect Tumor Growth and Metastasis

eBook: US $79 Special Offer (PDF + Printed Copy): US $158
Printed Copy: US $119
Library License: US $316
ISBN: 978-1-60805-520-3 (Print)
ISBN: 978-1-60805-256-1 (Online)
Year of Publication: 2012
DOI: 10.2174/97816080525611120101


Tumor development and progression are multi-factorial processes, in which genomic alterations and modifications in gene expression in pre-malignant cells are joined by deleterious microenvironmental factors. The tumor microenvironment contains stroma cells and leukocytes, soluble factors and matrix components. The intensive interplay that exists between the host factors and the tumor cells plays a major role in dictating the final outcome of the malignant process.

Inflammatory mediators are pivotal microenvironmental factors present in the tumor milieu. These inflammatory components support cell growth and invasion, induce mutagenesis, increase angiogenicity, and suppress potential anti-tumor immune functions. The inflammatory constituents that prevail in tumors include leukocytes and soluble mediators - cytokines and chemokines.

This e-book describes the roles played by these mediators in malignancy, and explains the basis for their consideration as therapeutic targets in cancer.

The e-book is a timely overview of the roles played by inflammatory soluble mediators in neoplastic diseases. The topics addressed in this volume serve as a handy reference to investigators studying basic aspects of the malignant tumor growth, to clinicians who wish to better understand the processes involved in malignancy, and to pharmacological professionals seeking novel candidates for therapeutic intervention in cancer.

Indexed in: Book Citation Index, Science Edition, Web of Science, BIOSIS Previews, Scopus, EBSCO.


- Pp. i
Yinon Ben-Neirah
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- Pp. ii-iii (2)
Adit Ben-Baruch
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List of Contributors

- Pp. iv-vii (4)
Adit Ben-Baruch
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The Metastatic Microenvironment

- Pp. 3-13 (11)
Sivan Izraely, Isaac P. Witz
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Tumor-Infiltrating Inflammatory Cells as Possible Therapeutic Targets

- Pp. 14-28 (15)
Paola Larghi, Chiara Porta, Elena Riboldi, Paola Allavena, Alberto Mantovani, Antonio Sica
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TNF and Cancer: Friends and/or Foes?

- Pp. 29-56 (28)
Loris Bertazza, Simone Mocellin, Mark DeWitte, Donato Nitti
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IL-1 is a Major Cytokine that Controls the Balance between Inflammation and Immunity in the Tumor Microenvironment

- Pp. 57-80 (24)
Ron N. Apte, Elena Voronov
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ELR+ CXC Chemokines and their Role in Malignancy

- Pp. 81-87 (7)
Ellen C. Keeley, Borna Mehrad, Robert M. Strieter
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The CXCR3/CXCR3 Ligand Axis: Friend or Foe?

- Pp. 88-98 (11)
Yanchun Li, Amy M. Fulton
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The Inflammatory CC Chemokines CCL2 and CCL5 in Malignancy: Leukocyte Migration and Beyond

- Pp. 99-114 (16)
Adit Ben-Baruch
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Homeostatic Chemokines

- Pp. 115-122 (8)
Amanda Burkhardt, Albert Zlotnik
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Inflammation and Beyond: Complex Roles for TGF- β in the Tumor Microenvironment

- Pp. 123-154 (32)
Dror Luger, Lalage M. Wakefield
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Microenvironmental Mediators as Therapeutic Targets in Malignancy

- Pp. 155-167 (13)
Amnon Peled
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- Pp. 168-173 (6)
Adit Ben-Baruch
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