Frontiers in Medicinal Chemistry

Volume 3

eBook: US $44 Special Offer (PDF + Printed Copy): US $357
Printed Copy: US $335
Library License: US $176
ISSN: 1567-2042 (Print)
ISSN: 1875-5763 (Online)
ISBN: 978-1-60805-674-3 (Print)
ISBN: 978-1-60805-206-6 (Online)
Year of Publication: 2006
DOI: 10.2174/97816080520661060301

Introduction

Frontiers in Medicinal Chemistry is a book series devoted to the review of areas of important topical interest to medicinal chemists and others in allied disciplines. Frontiers in Medicinal Chemistry covers all the areas of medicinal chemistry, including developments in rational drug design, bioorganic chemistry, high-throughput screening, combinatorial chemistry, compound diversity measurements, drug absorption, drug distribution, metabolism, new and emerging drug targets, natural products, pharmacogenomics, chemoinformatics, and structure-activity relationships.

Medicinal chemistry as a discipline is rapidly maturing. The study of how structure and function are related is absolutely essential to understanding the molecular basis of life. Frontiers in Medicinal Chemistry aims to contribute in a major way to the growth of scientific knowledge and insight, and facilitate the discovery and development of new therapeutic agents to treat debilitating human disorders. This book series is essential for any medicinal chemist who wishes to be kept informed and up-to-date with the latest and the most important advances.

Indexed in: Scopus, EMBASE, Chemical Abstracts, EBSCO, Ulrich's Periodicals Directory.

Contributors

Co-Editor(s):
Atta-ur-Rahman
H.E.J. Research Institute of Chemistry
University of Karachi
Karachi, 75270
Pakistan


Allen B. Reitz
Johnson & Johnson Pharmaceutical Research and Development, Spring House
Pennsylvania , 19477
USA




Associate Editor(s):
M. Iqbal Choudhary
H.E.J. Research Institute of Chemistry
University of Karachi
Karachi, 75270
Pakistan


Cheryl P. Kordik
Johnson & Johnson Pharmaceutical Research and Development, Spring House
Pennsylvania , 19477
USA




Editorial Advisory Board:
P.R. Bernstein
University of Delaware
Newark
DE
USA


C. Bor-Luen
National Taiwan University, Taipei
Taiwan
R.O.C.


R. Efremov
M.M. Shemyakin & Yu.A. Ovchinnikov Institute of Bioorganic Chemistry
Moscow
Russia


C. Garcia-Echeverria
Sanofi-Aventis
Paris
France


D. Hadjipavlou-Litina
Arristotle Universith of Thessaloniki
Thessaloniki
Greece


D. Heymann
University of Nantes
Nantes
France


D.A. Jans
Nuclear Signaling Laboratory, Monash University
Australia


G.B. Mahady
University of Illinois at Chicago
Chicago
IL
USA


B. Malawska
Jagiellonian University Collegium Medicum
Kraków
Poland


C. Philippe
Sciences and Technologies University of Lille
Lille
France




Contributor(s):
Thang K. Chiu
NIH, NIDDK, Laboratory of Molecular Biology
Building 5, Room 338
Bethesda
MD , 20892-0560
USA


David R. Davies
NIH, NIDDK, Laboratory of Molecular Biology
Building 5, Room 338
Bethesda
MD , 20892-0560
USA


Tomozumi Imamichi
Laboratory of Human Retrovirology, Applied and Development Research Program
Science Applications International Corporation-Frederick, Inc., National Institute of Allergy and Infectious Diseases at Frederick
P.O. Box B, Building 550, Room 126
Frederick
MD, 21702
USA


Michael D. Sosin
University Department of Medicine
Sandwell & West Birmingham Hospitals NHS Trust, City Hospital
Birmingham , B18 7QH
UK


Gurbir S. Bhatia
University Department of Medicine
Sandwell & West Birmingham Hospitals NHS Trust, City Hospital
Birmingham , B18 7QH
UK


Gregory Y.H. Lip
University Department of Medicine
Sandwell & West Birmingham Hospitals NHS Trust, City Hospital
Birmingham , B18 7QH
UK


Russell C. Davis
University Department of Medicine
Sandwell & West Birmingham Hospitals NHS Trust, City Hospital
Birmingham , B18 7QH
UK


Marcin Gruchala
Department of Biotechnology and Molecular Medicine, First Department of Cardiology
A.I. Virtanen Institute for Molecular Sciences, University of Kuopio
Medical University of Gdansk
Finland
Poland


Himadri Roy
Department of Biotechnology and Molecular Medicine
A.I. Virtanen Institute for Molecular Sciences
University of Kuopio
Finland


Shalini Bhardwaj
Department of Biotechnology and Molecular Medicine
A.I. Virtanen Institute for Molecular Sciences
University of Kuopio
Finland


Seppo Ylä-Herttuala
Department of Biotechnology and Molecular Medicine, Department of Medicine, University of Kuopio
A.I. Virtanen Institute for Molecular Sciences, University of Kuopio, University of Kuopio
Kuopio University Hospital
Finland


Thomas M. Mavromoustakos
National Hellenic Research Foundation
Institute of Organic and Pharmaceutical Chemistry
Vas. Constantinou 48
Athens , 11635
Greece


Maria V. Zervou
National Hellenic Research Foundation
Institute of Organic and Pharmaceutical Chemistry
Vas. Constantinou 48
Athens , 11635
Greece


Panagiotis G. Zoumpoulakis
National Hellenic Research Foundation
Institute of Organic and Pharmaceutical Chemistry
Vas. Constantinou 48
Athens , 11635
Greece


Péter Mátyus
Department of Organic Chemistry
Semmelweis University
Budapest
Hungary


Ildikó Varga
Ivax Drug Research Institute
Budapest
Hungary


Tivadar Rettegi
Ivax Drug Research Institute
Budapest
Hungary


Antal Simay
Ivax Drug Research Institute
Budapest
Hungary


Péter Kovács
Department of Organic Chemistry
Semmelweis University
Budapest
Hungary


László Károlyházy
Department of Organic Chemistry
Semmelweis University
Budapest
Hungary


Ákos Kocsis
Department of Organic Chemistry
Semmelweis University
Budapest
Hungary


Szilvia Vajda
Department of Pharmacology and Pharmacotherapy
University of Szeged
Szeged
Hungary


András Varró
Department of Pharmacology and Pharmacotherapy
University of Szeged
Szeged
Hungary


István Pénzes
Department of Anesthesiology and Intensive Therapy
Budapest
Hungary


Julius Gy. Papp
Department of Pharmacology and Pharmacotherapy, Division of Cardiovascular Pharmacology
University of Szeged, Hungarian Academy of Sciences
Szeged
Hungary


Sally A. Hutchinson
CSIRO Textile and Fibre Technology
Henry St, Belmont VIC
Oregon, 3216
Australia


Peter J. Scammells
Department of Medicinal Chemistry
Victorian College of Pharmacy, Monash University
381 Royal Parade, Parkville VIC
London, 3052
Australia


William A. Banks
Department of Internal Medicine
GRECC, Veterans Affairs Medical Center-St. Louis and Saint Louis University School of Medicine
Division of Geriatrics, 915 N. Grand Blvd., St. Louis
London
MO , 63106
USA


Margaret A. Brimble
Department of Chemistry
University of Auckland
23 Symonds St.
Auckland
New Zealand


Mark S. Levi
Department of Pharmacology & Toxicology
University of Arkansas for Medical Sciences
4301 W. Markham St.
Little Rock
AR , 72205
USA


William H. Bunnelle
Abbott Laboratories Global Pharmaceutical Research and Development
Department R47W, AP9A-1, Abbott Park
Illinois , 60064
USA


Michael J. Dart
Abbott Laboratories Global Pharmaceutical Research and Development
Department R47W, AP9A-1, Abbott Park
Illinois , 60064
USA


Michael R. Schrimpf
Abbott Laboratories Global Pharmaceutical Research and Development
Department R47W, AP9A-1, Abbott Park
Illinois , 60064
USA


Pierre Francotte
Natural and Synthetic Drugs Research Center, Dept of Medicinal Chemistry
University of Liège
Av. de l'Hôpital, 1, B36
Liège, 4000
Belgium


Pascal de Tullio
Natural and Synthetic Drugs Research Center, Dept of Medicinal Chemistry
University of Liège
Av. de l'Hôpital, 1, B36
Liège, 4000
Belgium


Pierre Fraikin
Natural and Synthetic Drugs Research Center, Dept of Medicinal Chemistry
University of Liège
Av. de l'Hôpital, 1, B36
Liège, 4000
Belgium


Bernard Pirotte
Natural and Synthetic Drugs Research Center, Dept of Medicinal Chemistry
University of Liège
Av. de l'Hôpital, 1, B36
Liège, 4000
Belgium


Boman G. Irani
Department of Medicinal Chemistry
University of Florida
PO Box 100485
Gainesville
FL, 32610-0485
USA


Jerry R. Holder
Department of Medicinal Chemistry
University of Florida
PO Box 100485
Gainesville
FL, 32610-0485
USA


Aleksandar Todorovic
University of Florida, Department of Medicinal Chemistry
PO Box 100485
Gainesville
FL, 32610-0485
USA


Andrzej M. Wilczynski
Department of Medicinal Chemistry
University of Florida
PO Box 100485
Gainesville
FL, 32610-0485
USA


Christine G. Joseph
Department of Medicinal Chemistry
University of Florida
PO Box 100485
Gainesville
FL, 32610-0485
USA


Krista R. Wilson
Department of Medicinal Chemistry
University of Florida
PO Box 100485
Gainesville
FL, 32610-0485
USA


Carrie Haskell-Luevano
Department of Medicinal Chemistry
University of Florida
PO Box 100485
Gainesville
FL, 32610-0485
USA


Zhonghua Pei
Metabolic Disease Research
Global Pharmaceutical Research and Development
Abbott Laboratories
Abbott Park
IL , 60064
USA


Gang Liu
Metabolic Disease Research
Global Pharmaceutical Research and Development
Abbott Laboratories
Abbott Park
IL , 60064
USA


Thomas H. Lubben
Metabolic Disease Research
Global Pharmaceutical Research and Development
Abbott Laboratories
Abbott Park
IL , 60064
USA


Bruce G. Szczepankiewicz
Metabolic Disease Research
Global Pharmaceutical Research and Development
Abbott Laboratories
Abbott Park
IL , 60064
USA


Thomas D.C. Thomas
Department of Pathology
University of Cambridge
UK


Paola Zaccone
Department of Pathology
University of Cambridge
UK


David W. Dunne
Department of Pathology
University of Cambridge
UK


Anne Cooke
Department of Pathology
University of Cambridge
UK


Martin Eggert
Department of Internal Medicine and Center of Rheumatology
Rostock Clinic South, Südring 81
Rostock, D-18059
Germany


Andreas Klüter
Department of Internal Medicine and Center of Rheumatology
Rostock Clinic South, Südring 81
Rostock, D-18059
Germany


Uwe K. Zettl
Department of Neurology
University of Rostock
Gehlsheimer Str. 20
Rostock, D- 18147
Germany


Gunther Neeck
Department of Internal Medicine and Center of Rheumatology
Rostock Clinic South, Südring 81
Rostock, D-18059
Germany


Mark Levis
Johns Hopkins University School of Medicine, Department of Oncology
Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, Bunting-Blaustein Cancer Research Building
Room 251, 1650 Orleans Street, Baltimore
Maryland , 21231-1000
USA


Donald Small
Johns Hopkins University School of Medicine, Departments of Oncology and Pediatrics
Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, Bunting-Blaustein Cancer Research Building
Room 251, 1650 Orleans Street, Baltimore
Maryland , 21231-1000
USA


Luca Munaron
Department of Animal and Human Biology
University of Torino,, Nanostructured Interfaces and Surfaces Centre of Excellence (NIS)
Via Accademia Albertina 13
Torino, I-10123
Italy


Susanna Antoniotti
Department of Animal and Human Biology
University of Torino
Via Accademia Albertina 13
Torino, I-10123
Italy


Alessandra Fiorio Pla
Department of Animal and Human Biology
University of Torino
Via Accademia Albertina 13
Torino, I-10123
Italy


Davide Lovisolo
Department of Animal and Human Biology
University of Torino,, Nanostructured Interfaces and Surfaces Centre of Excellence (NIS)
Via Accademia Albertina 13
Torino, I-10123
Italy


O.M. Zack Howard
Center for Cancer Research (CCR), Laboratory of Molecular Immunoregulation (LMI)
Carole L. Galligan National Cancer Institute (NCI)
NCI-Frederick, P.O. Box B
Frederick
MD , 21702
USA


Kuo-Chen Chou
Gordon Life Science Laboratory
13784 Torrey Del Mar,
California , 92130
USA
/
Department of Biomedical Engineering
Shanghai Jiaotong University
Shanghai , 200030
China


György Dormán
ComGenex
H-1031 Budapest, Záhony u 7.
Hungary


Péter Krajcsi
Cooperative Research Center
Solvo Biotechnology, Gyar u. 2, Semmelweis University
P.O. Box 131, Budapest H-1367
Budaörs, H-2040
Hungary


László G. Puskás
Laboratory of Functional Genomics, Biological Research Center
Hungarian Academy of Sciences
P.O. Box 521
Szeged, H-6701
Hungary


Zoltán Kovári
Gedeon Richter, Ltd., Department of Computer Assisted Drug Discovery
P.O. Box 27
Budapest, H- 1475
Hungary


Zsolt Lo"rincz
RecomGenex, Hungarian Academy of Sciences
Institute of Enzymology, Biological Research Center
Záhony u 7
Budapest, H-1031
Hungary


László Ürge
ComGenex
Záhony u 7.
Budapest, H-1031
Hungary


Ferenc Darvas
ComGenex
Záhony u 7.
Budapest, H-1031
Hungary


Oranit Dror
School of Computer Science, Tel Aviv University
Tel Aviv, 69978
Israel


Alexandra Shulman-Peleg
School of Computer Science, Tel Aviv University
Tel Aviv, 69978
Israel


Ruth Nussinov
Department of Human Genetics and Molecular Medicine
Sackler Faculty of Medicine, Tel Aviv University
Tel Aviv, 69978
Israel
/
Basic Research Program, SAIC-Frederick, Inc.
Laboratory of Experimental and Computational Biology
NCI - Frederick, Bldg 469, Rm 151
Frederick
MD , 21702
USA


Haim J. Wolfson
School of Computer Science, Tel Aviv University
Tel Aviv, 69978
Israel


Dina Schneidman-Duhovny
School of Computer Science, Tel Aviv University
Tel Aviv, 69978
Israel


Ruth Nussinov
Department of Human Genetics and Molecular Medicine
Sackler Faculty of Medicine, Tel Aviv University
Tel Aviv, 69978
Israel
/
Basic Research Program, SAIC-Frederick, Inc.
Laboratory of Experimental and Computational Biology, NCI - Frederick
Frederick
MD , 21702
USA


Haim J. Wolfson
School of Computer Science, Tel Aviv University
Tel Aviv, 69978
Israel


Marcel J. de Groot
Department of Discovery Chemistry
, Pfizer Global Research & Development, Sandwich Laboratories
Kent CT13 9NJ
United Kingdom


Stewart B. Kirton
Department of Chemistry
University of Leicester
Leicester, LE1 7RH
UK


Michael J. Sutcliffe
Department of Chemistry, Department of Biochemistry
University of Leicester
Leicester, LE1 7RH
UK


Benoit Deprez
Faculté des Sciences Pharmaceutiques et Biologiques
Institut Pasteur de Lille, Université de Lille 2
3 rue du Pr Calmette
Lille Cedex, F-59006
France


Rebecca Deprez-Poulain
Faculté des Sciences Pharmaceutiques et Biologiques
Institut Pasteur de Lille, Université de Lille 2
3 rue du Pr Calmette
Lille Cedex, F-59006
France


Tingjun Hou
College of Chemistry and Molecular Engineering, Peking University
3 rue du Pr Calmette
Beijing , 100871
China


Xiaojie Xu
College of Chemistry and Molecular Engineering, Peking University
3 rue du Pr Calmette
Beijing , 100871
China


Nastiti Wijayanti
Institut für Klinische Immunologie und Transfusionsmedizin der Justus- Liebig Universität Giessen, Langhansstr. 7
Giessen, 35392
Germany


Stephan Immenschuh
Institut für Klinische Immunologie und Transfusionsmedizin der Justus- Liebig Universität Giessen, Langhansstr. 7
Giessen, 35392
Germany




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