Editor: Michel Goldberg

Series Title: Frontiers between Science and Clinic in Odontology

Amelogenins: Multifaceted Proteins for Dental and Bone Formation and Repair

Volume 1

eBook: US $99 Special Offer (PDF + Printed Copy): US $168
Printed Copy: US $119
Library License: US $396
ISSN: 2589-3076 (Print)
ISSN: 2210-2841 (Online)
ISBN: 978-1-60805-606-4 (Print)
ISBN: 978-1-60805-171-7 (Online)
Year of Publication: 2010
DOI: 10.2174/97816080517171100101

Introduction

This volume is the 1st in a series of Ebooks that bridges the gap between advances in science and clinical practice in odontology. Recent advances in biology, materials science and tissue engineering are increasingly viewed as being of enormous clinical potential. Stem cell research has opened up the possibility of reconstructing teeth from the association of epithelial and mesanchymal embryonic or adult cells, as an exciting alternative to metal implants. This Ebook will examine the multifunctional nature of a group of proteins known as the amelogenins. Latest studies indicate that this protein regulates the initiation and growth of hydroxyapatite crystals during the mineralization of enamel. In addition, amelogenins organize enamel rods during tooth development, and also aid in the development of cementum by directing cells that form the cementum to the root surface of the teeth. The aim of this book is to serve as a bridge between basic biology and biomaterial sciences, and to inform clinicians about the implications of recent advances within these fields for clinical practice.

Indexed in: Chemical Abstracts, EBSCO, Ulrich's Periodicals Directory.

Preface

- Pp. i-v (5)
Michel Goldberg
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Contributors

- Pp. vi-ix (4)
Michel Goldberg
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Origin and Relationships of Amelogenin, and the Evolutionary Analysis of its Conserved and Variable Regions in Tetrapods

- Pp. 1-18 (18)
Jean-Yves Sire

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Amelogenin Gene Regulation

- Pp. 19-24 (6)
Megan K. Pugach and Carolyn W. Gibson

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Lessons from the Amelogenin Knockout Mice

- Pp. 25-31 (7)
Naoto Haruyama, Junko Hatakeyama, Yuji Hatakeyama, Carolyn W. Gibson and Ashok B. Kulkarni

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Amelogenins: A Review of Formative and Degradative Aspects, and Transgene Expression in Bone Cells

- Pp. 32-41 (10)
Rima Wazen, Sylvia Francis Zalzal and Antonio Nanci

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The Non-Amelogenins: Ameloblastin and Enamelin

- Pp. 42-55 (14)
Yong-Hee P. Chun, Jan C-C Hu and James P. Simmer

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Potential Role of Adaptor Protein Complex-3 (Ap-3) In Amelogenesis

- Pp. 56-63 (8)
Jason L. Shapiro, Rodrigo S. Lacruz, Steven J. Brookes, S. Petter Lyngstadaas and Michael L. Paine

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Amelogenin: Possible Roles in Regeneration of Tooth Supporting Tissues, in Long Bone and During Embryonic Craniofacial Complex Development

- Pp. 64-87 (24)
Dan Deutsch, Amir Haze, Yael Gruenbaum-Cohen, Shay Sharon, Dekel Shilo, Nechama C. Silverstein and Anat Blumenfeld

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Consequences of Amelogenin Mutations: Implications in Amelogenesis Imperfecta

- Pp. 88-98 (11)
J Timothy Wright

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Degradation of Enamel Matrix Proteins

- Pp. 99-105 (7)
John D. Bartlett, Coralee E Tye, Tabitha A. Abrazinski, Jerry Antone, Grace F. Lopez and Ramaswamy Sharma

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Intrinsic Disorder in Amelogenin

- Pp. 106-132 (27)
Janet Moradian-Oldak and Rajamani Lakshminarayanan

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The Role of Amelogenin in Dental Enamel Formation: A Universal Strategy for Protein-Mediated Biomineralization

- Pp. 133-142 (10)
Henry C. Margolis and Elia Beniash

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Role of Spliced Forms of Amelogenins as Signaling Molecules

- Pp. 143-162 (20)
Arthur Veis, Kevin A. Tompkins and Stanca Iacob

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Amelogenin Exons 8 and 9

- Pp. 163-173 (11)
Wu Li, Jean Yves-Sire, Yoshiro Takano, Mary MacDougall, Michel Goldberg and Pamela DenBesten

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In Vivo Effects of Amelogenins on Reparative Dentin Formation

- Pp. 174-190 (17)
Yassine Harichane, Sasha Dimitrova-Nakov, Anne Poliard, Arthur Veis, Pamela DenBesten, Odile Kellermann and Michel Goldberg

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Cell to Matrix Interactions Suggests a Pathway for Enamel Regeneration Using Artificial Matrices

- Pp. 191-207 (17)
M. L. Snead, Z. Huang, C. J. Newcomb, M. L. Paine, S. N. White Y. Xu, Y. Zhou, R. S. Lacruz and S. I. Stupp

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Signaling Effect of Leucine-Rich Amelogenin Peptide (Lrap) on Bone Regeneration

- Pp. 208-213 (6)
Yan Zhou, Christina. J. Newcomb, Rungnapa Warotayanont, Malcolm L. Snead and S. I. Stupp

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Clinical Applications of an Enamel Matrix Protein Derivative in Regenerative Periodontal Therapy

- Pp. 214-228 (15)
Anton Sculean, Dieter D. Bosshardt and Michel Brecx

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Index

- Pp. 229-231 (3)
Michel Goldberg
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