Editors: Atta-ur-Rahman, FRS, M. Iqbal Choudhary

Anti-Angiogenesis Drug Discovery and Development

Volume 1

eBook: US $34 Special Offer (PDF + Printed Copy): US $136
Printed Copy: US $119
Library License: US $136
ISSN: 2452-3240 (Print)
ISSN: 2210-268X (Online)
ISBN: 978-1-60805-648-4 (Print)
ISBN: 978-1-60805-162-5 (Online)
Year of Publication: 2011
DOI: 10.2174/97816080516251110101


The inhibition of angiogenesis is an effective mechanism of slowing down tumor growth and malignancies. The process of induction or pro-angiogenesis is highly desirable for the treatment of cardiovascular diseases, wound healing disorders, etc. Efforts to understand the molecular basis, both for inhibition and induction, have yielded fascinating results.

Anti-angiogenesis Drug Discovery and Development provides an excellent compilation of well-written reviews on various aspects of the anti-angiogenesis process. These reviews have been contributed by leading practitioners in drug discovery science and highlight the major developments in this exciting field in the last two decades. The feast of these reader-friendly reviews on topics of great scientific importance – many of which are considered significant medical breakthroughs, makes this book excellent reading both for the novice as well as for expert medicinal chemists and clinicians.

Indexed in: Scopus, EBSCO, Ulrich's Periodicals Directory.


- Pp. i-iii (3)
Atta-ur-Rahman and M. Iqbal Choudhary
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- Pp. iv-vi (3)
Atta-ur-Rahman and M. Iqbal Choudhary
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Antiangiogenic Treatment of Hematological Tumors

- Pp. 1-11 (11)
Domenico Ribatti, Vito Longo and Angelo Vacca
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Multiligands/Rage Axis: An Emerging Actor in Tumour Angiogenesis

- Pp. 12-33 (22)
Armando Rojas, Hector Figueroa, Ileana Gonzalez, Jacqueline Romero and Miguel Morales

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Ginsenoside Rg3 and Rh2: The Anti-Cancer and Anti- Angiogenic Saponins from Ginseng

- Pp. 34-57 (24)
Patrick Y.K. Yue, Y. Huang and Ricky N.S. Wong

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Antiangiogenic Therapy for Cardiovascular Diseases

- Pp. 58-69 (12)
Mustafa Sacar and Yalın Tolga Yaylali
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Role of Phosphoinositide 3-Kinases and Angiogenesis in Cardiovascular Diseases

- Pp. 70-85 (16)
Cinzia Perrino, Giovanni Esposito, Giuseppe Gargiulo, Gianluigi Pironti, Gabriele G. Schiattarella and Massimo Chiariello

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Redox Regulation of Angiogenesis: NADPH Oxidase as a Drug Target

- Pp. 86-115 (30)
Elsa C. Chan, Hitesh Peshavariya, Srinivasa Raju Datla, Gregory J. Dusting and Fan Jiang

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Thymidine Phosphorylase Inhibitors

- Pp. 116-147 (32)
Radim Nencka

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Neurological Complications of Antiangiogenic Therapy

- Pp. 148-170 (23)
Jose Tarcisio Feitosa Vieira da Silva, Italo Gustavo Lima Monteiro, Carlos Tairo Diogenes Holanda and Francisco de Assis Aquino Gondim

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Autoimmunity and Angiogenesis

- Pp. 171-186 (16)
A. Mirshafiey and R. Boghozian

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Author Index to Volume 1

- Pp. 187
Atta-ur-Rahman and M. Iqbal Choudhary
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.Frontiers in Anti-infective Drug Discovery.
.Frontiers in Drug Design and Discovery.
.In Silico and In vitro Approaches to Screen the Anti-TB Activity of Benzothiazole Analogs.
.Anti-Obesity Drug Discovery and Development.