Editors: Atta-ur-Rahman, Iqbal Choudhary

Frontiers in Anti-Cancer Drug Discovery

Volume 1

eBook: US $44 Special Offer (PDF + Printed Copy): US $363
Printed Copy: US $341
Library License: US $176
ISSN: 2451-8395 (Print)
ISSN: 1879-6656 (Online)
ISBN: 978-1-60805-626-2 (Print)
ISBN: 978-1-60805-161-8 (Online)
Year of Publication: 2010
DOI: 10.2174/97816080516181100101

Introduction

Frontiers in Anti-Cancer Drug Discovery” is an eBook series devoted to publishing the latest and the most important advances in Anti-Cancer drug design and discovery. Eminent scientists write contributions on all areas of rational drug design and drug discovery including medicinal chemistry, in-silico drug design, combinatorial chemistry, high-throughput screening, drug targets, recent important patents, and structure-activity relationships. The eBook series should prove to be of interest to all pharmaceutical scientists involved in research in Anti-Cancer drug design and discovery. Each volume is devoted to the major advances in Anti-Cancer drug design and discovery. The eBook series is essential reading to all scientists involved in drug design and discovery who wish to keep abreast of rapid and important developments in the field.

Indexed in: Book Citation Index, Science Edition, BIOSIS Previews, EMBASE, Chemical Abstracts, EBSCO, Ulrich's Periodicals Directory.

Preface

- Pp. i-ii (2)
Atta-ur-Rahman and M. Iqbal Choudhary
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Foreword

- Pp. iii
John K. Buolamwini
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Contributors

- Pp. iv-ix (6)
Atta-ur-Rahman and M. Iqbal Choudhary
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Targeting Ribonucleotide Reductase for Cancer Chemotherapy

- Pp. 1-30 (30)
Nuno M.F.S.A. Cerqueira, Pedro A. Fernandes and Maria J. Ramos
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Thymidine Phosphorylase/Platelet-Derived Endothelial Cell Growth Factor as a Target for Capecitabine: From Biology to the Bedsid

- Pp. 31-54 (24)
Girolamo Ranieri, Aldo Maria Roccaro, Angelo Vacca and Domenico Ribatti

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Inhibitors of the Plasminogen Activation System - Promising New Agents for Suppressing Breast Cancer Metastasis

- Pp. 55-78 (24)
Joel D.A. Tyndall, Michael J. Kelso and Marie Ranson
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Histone Deacetylase Inhibitors in Cancer Therapy

- Pp. 79-115 (37)
Alfredo Budillon, Francesca Bruzzese and Elena Di Gennaro

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Second Generation Abl Tyrosine Kinase Inhibitors and Novel Compounds to Eliminate the Bcr-Abl/T315I Clone (Second Edition)

- Pp. 116-131 (16)
Shinya Kimura

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Aurora Kinase Family: A New Target for Anticancer Drug

- Pp. 132-148 (17)
Teresa Macarulla, M. Elena Elez, Francisco Javier Ramos and Josep Tabernero

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Molecularly Targeted Therapy in Breast Cancer: The Tyrosine Kinase Inhibitors

- Pp. 149-157 (9)
Zeina A. Nahleh

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New Perspectives in the Treatment of Melanoma: Anti-Angiogenic and Anti-Lymphangiogenic Strategies

- Pp. 158-167 (10)
Caterina A.M. La Porta

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Therapeutic Potential of Endogenous Angiogenesis Inhibitors for Cancer Therapy: Historical Perspective and Future Direction

- Pp. 168-193 (26)
Mohanraj Dhanabal and Natarajan Sethuraman

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Calcium Signals in Endothelium and their Role in the Control of Angiogenesis

- Pp. 194-218 (25)
Luca Munaron

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Novel Purine Nucleoside Analogues for Hematological Malignancies

- Pp. 219-240 (22)
Anna Korycka, Ewa Lech-Maranda and Tadeusz Robak

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The Place of Somatostatin Analogs in the Diagnosis and Treatment of the Neuoroendocrine Glands Tumors

- Pp. 241-272 (32)
Gabriela Melen-Mucha, Hanna Lawnicka, Dorota Kierszniewska-Stepien, Jan Komorowski and Henryk Stepien

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Bortezomib in the Treatment of Cancer

- Pp. 273-283 (11)
Aldo M. Roccaro, Angelo Vacca and Domenico Ribatti

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Cetuximab: Its Use in Combination with Radiation Therapy and Chemotherapy in the Multimodality Treatment of Head and Neck Cancer

- Pp. 284-297 (14)
Timothy D. Wagner and Gary Y. Yang

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Platinum-Based Anticancer Agents

- Pp. 298-339 (42)
Irena Kostova

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c-Myc and Downstream Targets in the Pathogenesis and Treatment of Cancer

- Pp. 340-379 (40)
Sam Robson, Inga Pukonen, Sylvie Abouna, Stella Pelengaris and Michael Khan

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Small Molecule Vascular Disrupting Agents: Potential New Drugs for Cancer Treatment, a 2009 Update

- Pp. 380-427 (48)
Sui Xiong Cai

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Developments in Targeted Therapy of Advanced Gastrointestinal Stromal Tumors

- Pp. 428-448 (21)
Piotr Rutkowski, Malgorzata Symonides, Marcin Zdzienicki and Janusz A. Siedlecki

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Therapeutic Transfer of DNA Encoding Adenoviral E1A†

- Pp. 449-464 (16)
Helmut Deissler and Bertram Opalka

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Compositions for Treatment of Cancer and Inflammation

- Pp. 465-480 (16)
Shahar Lev-Ari, Dov Lichtenberg and Nadir Arber

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The Androgen Receptor as Putative Therapeutic Target in Hormone-Refractory Prostate Cancer

- Pp. 481-496 (16)
Yukio Kageyama, Nobuhiko Hyochi, Kazunori Kihara and Hiroshi Sugiyama

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Older and New Formulations of Cladribine: Pharmacology and Clinical Efficacy in Hematological Malignancies

- Pp. 497-524 (28)
Tadeusz Robak, Anna Korycka and Ewa Robak

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Developments of New Compounds and New Strategies in the Field of Cytotoxic Nucleoside Analogues

- Pp. 525-540 (16)
Lars P. Jordheim and Charles Dumontet

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PET in Anti-Cancer Drug Development and Therapy

- Pp. 541-551 (11)
Rakesh Kumar, Dhanpathi Halanaik and Saurabh Dahiya

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The Anti-Cancer Charm of Flavonoids: A Cup-of-Tea Will Do You Good!

- Pp. 552-587 (36)
Amr Amin and Michael Buratovich

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Prevention and Treatment of Regimen-Related Mucosal Toxicity

- Pp. 588-600 (13)
Joanne M. Bowen

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Recent Patents on Bacterial Proteins as Potential Anticancer Agents

- Pp. 601-622 (22)
Arsenio M.Fialho and Ananda M.Chakrabarty

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Recent Patents on Therapeutic Agents for Cancer

- Pp. 623-740 (118)
Xun Li, Yalin Li and Wenfang Xu

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Review of Selected Patents for Cancer Therapy Targeting: Tumor Angiogenesis

- Pp. 741-757 (17)
Mark N. Kirstein and Arkadiusz Z. Dudek

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Targeting Vesicle Trafficking in Cancer Therapeutics

- Pp. 758-776 (19)
Paul K. Wright

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Author Index to Volume 1

- Pp. 778-779 (2)
Bentham Science Publishers
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