Editors: Atta-ur-Rahman , M. Iqbal Choudhary

Frontiers in CNS Drug Discovery

Volume 1

eBook: US $44 Special Offer (PDF + Printed Copy): US $303
Printed Copy: US $281
Library License: US $176
ISSN: 1879-6656 (Print)
ISSN: 1879-6613 (Online)
ISBN: 978-1-60805-363-6 (Print)
ISBN: 978-1-60805-159-5 (Online)
Year of Publication: 2010
DOI: 10.2174/97816080515951100101

Introduction

“Frontiers in CNS Drug Discovery” is an eBook series devoted to publishing the latest and the most important advances in Central Nervous System (CNS) drug design and discovery. Eminent scientists write contributions on all areas of rational drug design and drug discovery including medicinal chemistry, in-silico drug design, combinatorial chemistry, high-throughput screening, drug targets, recent important patents, and structure-activity relationships. The eBook series should prove to be of interest to all pharmaceutical scientists involved in research in CNS drug design and discovery. Each volume is devoted to the major advances in CNS drug design and discovery. The eBook series is essential reading to all scientists involved in drug design and discovery who wish to keep abreast of rapid and important developments in the field.

Indexed in: Book Citation Index, Science Edition, Web of Science, BIOSIS Previews, EMBASE, EBSCO.

Contributors

Editor(s):
Prof. Dr. Atta-ur-Rahman FRS
University of Karachi
Pakistan


M. Iqbal Choudhary
University of Karachi
Pakistan




Contributor(s):
Michela Pollicita
Department of Experimental Medicine and Biochemical Sciences
University of Rome "Tor Vergata"
Rome
Italy


Luigi Ronga
Department of Experimental Medicine and Biochemical Sciences
University of Rome "Tor Vergata"
Rome
Italy


Valentina Svicher
Department of Experimental Medicine and Biochemical Sciences
University of Rome "Tor Vergata"
Rome
Italy


Carlo Federico Perno
Department of Experimental Medicine and Biochemical Sciences
University of Rome "Tor Vergata"
Rome
Italy


Stefano Aquaro
Department of Experimental Medicine and Biochemical Sciences
University of Rome “Tor Vergata”
Rome
Italy
/
Department of Pharmaco-Biology
University of Calabria
Cosenza
Italy


Masahiro Kawahara
Department of Analytical Chemistry, School of Pharmaceutical Sciences
Kyushu University of Health and Welfare
1714-1 Yoshino-cho, Nobeoka-city
Miyazaki, 882-8508
Japan


Keiko Konoha
Department of Analytical Chemistry, School of Pharmaceutical Sciences
Kyushu University of Health and Welfare
1714-1 Yoshino-cho, Nobeoka-city
Miyazaki, 882-8508
Japan


Tetsuya Nagata
Department of Analytical Chemistry
School of Pharmaceutical Sciences, Kyushu University of Health and Welfare
1714-1 Yoshino-cho, Nobeoka-city
Miyazaki, 882-8508
Japan


Yutaka Sadakane
Department of Analytical Chemistry
School of Pharmaceutical Sciences, Kyushu University of Health and Welfare
1714-1 Yoshino-cho, Nobeoka-city
Miyazaki, 882-8508
Japan


Miao-Kun Sun
Blanchette Rockefeller Neurosciences Institute, 9601 Medical Center Drive
Academic & Research Building, The 3rd floor
Rockville
MD, 20850
USA


Daniel L. Alkon
Blanchette Rockefeller Neurosciences Institute, 9601 Medical Center Drive
Academic & Research Building, The 3rd floor
Rockville
MD, 20850
USA


Jian Guan
Liggins Institute, The University of Auckland
New Zealand


Luis Marco
Instituto de Química Orgánica General (CSIC)
C/ Juan de la Cierva, 3
Madrid, 28006
Spain


María do Carmo Carreiras
Centro de Estudos de Ciências Farmacêuticas (CECF/FFUL)
Faculdade de Farmácia da Universidade de Lisboa
Av. Das Forças Armadas
Lisboa, 1600-083
Portugal


Katherine A. Price
Department of Pathology and the Centre for Neuroscience
The University of Melbourne, Victoria 3010 and The Mental Health Research Institute
Parkville
Victoria, 3052
Australia


Peter J. Crouch
Department of Pathology and the Centre for Neuroscience
The University of Melbourne, Victoria 3010 and The Mental Health Research Institute
Parkville
Victoria, 3052
Australia


Anthony R. White
Department of Pathology and the Centre for Neuroscience
The University of Melbourne, Victoria 3010 and The Mental Health Research Institute
Parkville
Victoria, 3052
Australia


Laurent Lecanu
McGill University Health Centre, Department of Medicine
The Research Institute of the McGill University Health Centre, Montreal, QC, Canada
Montreal
QC
Canada


Vassilios Papadopoulos
The Research Institute of the McGill University Health Centre
Montreal
QC
Canada
/
Department of Medicine
McGill University Health Centre
Montreal
QC
Canada
/
McGill University, Department of Biochemistry
Molecular and Cell Biology
Montreal
QC
Canada


Quincy J. Almeida
Sun Life Financial Movement Disorders Research and Rehabilitation Centre
Faculty of Science, BA-515, Wilfrid Laurier University
75 University Ave. W
Waterloo
ON, N2L 3C5
Canada


H. Christopher Hyson
Clinical Neurological Sciences, University of Western Ontario
339 Windermere Road, Room A10-325
London
ON, N6A 5A5
Canada


Karine Fabio
Dept. of Chemistry
Lehigh University
Bethlehem
PA, 18015
USA


Christophe Guillon
Dept. of Chemistry
Lehigh University
Bethlehem
PA, 18015
USA


Shi-Fang Lu
Azevan Pharmaceuticals, Inc.
Dept. of Biological Sciences, Lehigh University
Bethlehem
PA, 18015
USA


Ned D. Heindel
Dept. of Chemistry
Lehigh University
Bethlehem
PA, 18015
USA


Marvin Miller
Dept. of Chemistry
Univ. of Notre Dame
Notre Dame
IN, 46556-5670
USA


Craig F. Ferris
Azevan Pharmaceuticals, Inc.
Bethlehem
PA, 18015
USA
/
Dept. of Biological Sciences
Lehigh University
Bethlehem
PA, 18015
USA
/
Dept. of Psychology
Northeastern University
Boston
MA, 02115
USA


Michael J. Brownstein
Azevan Pharmaceuticals, Inc.
Bethlehem
PA, 18015
USA


Carrie Garripa
Dept. of Biological Sciences
Lehigh University
Bethlehem
PA, 18015
USA


Meir Steiner
McMaster University, Hamilton
Ontario, L8S4L8
Canada


Emil Coccaro
Dept. of Psychiatry
University of Chicago
Chicago
IL, 60637
USA


Eve Damiano
Azevan Pharmaceuticals, Inc.
Bethlehem
PA, 18015
USA


Gary A. Koppel
Azevan Pharmaceuticals, Inc.
Bethlehem
PA, 18015
USA


Neal G. Simon
Azevan Pharmaceuticals, Inc.
Bethlehem
PA, 18015
USA
/
Dept. of Biological Sciences
Lehigh University
Bethlehem
PA, 18015
USA


David M. Christmas
Psychopharmacology Unit, University of Bristol
Bristol
BS1 3NY
UK
/
School of Psychiatry and Clinical Neurosciences (M521)
University of Western Australia
Perth
Australia


Geetha Menon
School of Psychiatry and Clinical Neurosciences (M521), University of Western Australia
Perth
Australia


Sean D. Hood
School of Psychiatry and Clinical Neurosciences (M521), University of Western Australia
Perth
Australia


Alberto A. Rasia-Filho
Department of Basic Sciences and/or Program in Health Sciences
Universidade Federal de Ciências da Saúde de Porto Alegre
R. Sarmento Leite 245
Porto Alegre
RS, 90050-170
Brazil
/
Universidade Federal do Rio Grande do Sul, Graduation in Neurosciences, ICBS
R. Sarmento Leite 500
Porto Alegre
RS, 90050-170
Brazil
/
Universidade Federal de Ciências da Saúde de Porto Alegre, Graduation in Pathology
R. Sarmento Leite 245
Porto Alegre
RS, 90050-170
Brazil


Márcia Giovenardi
Department of Basic Sciences and/or Program in Health Sciences
Universidade Federal de Ciências da Saúde de Porto Alegre
R. Sarmento Leite 245
Porto Alegre
RS, 90050-170
Brazil


Rosa M.M. de Almeida
Universidade do Vale do Rio dos Sinos
Laboratory of Neurosciences and Graduation in Psychology, Av. Unisinos
São Leopoldo
RS, 93022-000
Brazil


Libor Velíšek
The Saul R. Korey of Department of Neurology and Dominick P. Purpura Department of Neuroscience
Einstein/Montefiore Comprehensive Epilepsy Management Center
Albert Einstein College of Medicine
Bronx
NY
USA


Jana Velíšková
The Saul R. Korey of Department of Neurology and Dominick P. Purpura Department of Neuroscience
Einstein/Montefiore Comprehensive Epilepsy Management Center
Albert Einstein College of Medicine
Bronx
NY
USA


Anna Capasso
Department of Pharmaceutical Sciences
University of Salerno
Via Ponte Don Melillo (84084) Fisciano
Salerno
Italy


Mariella Caputo
Department of Pharmaceutical Sciences
University of Salerno
Via Ponte Don Melillo (84084) Fisciano
Salerno
Italy


Mario Felice Tecce
Department of Pharmaceutical Sciences
University of Salerno
Salerno
Italy


Alberto Loizzo
Department of Pharmaceutical Sciences
University of Salerno
Via Ponte Don Melillo (84084) Fisciano
Salerno
Italy


Kenji Hashimoto
Division of Clinical Neuroscience
Chiba University Center for Forensic Mental Health
Chiba, 260-8670
Japan


Christa E. Müller
Pharmaceutical Chemistry I, University of Bonn
PharmaCenter Bonn, Pharmaceutical Institute
Germany


Sergi Ferré
Department of Health and Human Services
National Institute on Drug Abuse, Intramural Research Program
Baltimore
MD
USA


Leif Hertz
College of Basic Medical Sciences
China Medical University
Shenyang, 110001
P.R. China


Ye Chen
College of Basic Medical Sciences
China Medical University
Shenyang, 110001
P.R. China


Ada Maria Tata
Dept. of Cell and Developmental Biology
La Sapienza Università di Roma
Research Center of Neuroscience Daniel Bovet
P.le A. Moro, 5
Roma, 00185
Italy


Pranela Rameshwar
UMDNJ-New Jersey Medical School, Dept of Medicine-Hematology/Oncology
185 South Orange Avenue, MSB, Room E-579
Newark
NJ, 07103
USA


Rafael Roesler
Laboratory of Molecular Neuropharmacology, Department of Pharmacology
Cancer Research Laboratory, Academic Hospital Research Center (CPE-HCPA)
National Institute for Translational Medicine (INCT-TM)
Institute for Basic Health Sciences
Federal University of Rio Grande do Sul
Porto Alegre
RS, 90050-170
Brazil


Flávio Kapczinski
National Institute for Translational Medicine (INCT-TM)
Laboratory of Molecular Psychiatry and Bipolar Disorders Program,
Academic Hospital Research Center (CPE-HCPA), Federal University of Rio Grande do Sul
Porto Alegre
RS, 90035-003
Brazil
/

Porto Alegre
RS, 90035-003
Brazil


João Quevedo
National Institute for Translational Medicine (INCT-TM)
Porto Alegre
RS, 90035-003
Brazil
/
Laboratory of Neurosciences and Department of Medicine
University of Southern Santa Catarina
Criciúma
SC, 88806-000
Brazil


Felipe Dal Pizzol
Laboratory of Experimental Physiopathology and Department of Medicine
University of Southern Santa Catarina
Criciúma
SC, 88806-000
Brazil


Gilberto Schwartsmann
Cancer Research Laboratory, Academic Hospital Research Center (CPE-HCPA)
Department of Internal Medicine, Faculty of Medicine
National Institute for Translational Medicine (INCT-TM)
Federal University of Rio Grande do Sul
Porto Alegre
RS, 90035-003
Brazil


William K. Lim
Faculty of Medicine and Health Sciences, Universiti Malaysia Sarawak
Lot 77, KTLD Section 22, Jalan Tun Ahmad Zaidi Adruce Kuching
Sarawak
RS, 93150
Malaysia


Gabriel Barreda-Gómez
Department of Pharmacology
Faculty of Medicine, University of the Basque Country
Vizcaya, 48940- Leioa
Spain


Rafael Rodríguez-Puertas
Department of Pharmacology
Faculty of Medicine, University of the Basque Country
Vizcaya
Leioa, 48940
Spain


Paul W. Smith
Neuroscience Centre of Excellence in Drug Discovery
GlaxoSmithKline
Harlow
UK


Lee A. Dawson
Neuroscience Centre of Excellence in Drug Discovery
GlaxoSmithKline
Harlow
UK


Anna Capasso
Department of Pharmaceutical Sciences
University of Salerno
Via Ponte Don Melillo (84084) Fisciano
Salerno
Italy


Mariella Caputo
Department of Pharmaceutical Sciences
University of Salerno
Via Ponte Don Melillo (84084) Fisciano
Salerno
Italy


Mario Felice Tecce
Department of Pharmaceutical Sciences
University of Salerno
Via Ponte Don Melillo (84084) Fisciano
Salerno
Italy


Alberto Loizzo
Department of Pharmaceutical Sciences
University of Salerno
Via Ponte Don Melillo Fisciano
Salerno, 84084
Italy


María Teresa Moreno-Flores
Centro de Biología Molecular “Severo Ochoa” (C.S.I.C.-U.A.M.), C/ Nicolás Cabrera 1
Universidad Autónoma de Madrid
Madrid, 28049
Spain


Jesús Ávila
Centro de Biología Molecular “Severo Ochoa” (C.S.I.C.-U.A.M.), C/ Nicolás Cabrera 1
Universidad Autónoma de Madrid
Madrid, 28049
Spain


Joanne A. Harrold
School of Psychology, University of Liverpool
Liverpool, L69 7ZA
UK


Jason C.G. Halford
School of Psychology, University of Liverpool
Liverpool, L69 7ZA
UK


Takayuki Masaki
Department of Internal Medicine 1
Faculty of Medicine, Oita University
1-1 Idaigaoka, Yufu-Hasama
Oita, 879-5593
Japan


Hironobu Yoshimatsu
Department of Internal Medicine 1
Faculty of Medicine, Oita University
1-1 Idaigaoka, Yufu-Hasama
Oita, 879-5593
Japan


József Nagy
Gedeon Richter Plc., Pharmacological and Drug Safety Research, Laboratory for Molecular Cell Biology
Budapest 10. P.O. Box 27, H-1475
Hungary


Sejal M. Mody
Department of Biochemistry and Biotechnology Research Institute
Hong Kong University of Science and Technology
Clear Water Bay, Kowloon
Hong Kong
China


Yueqing Hu
Department of Biochemistry and Biotechnology Research Institute
Hong Kong University of Science and Technology
Clear Water Bay, Kowloon
Hong Kong
China


Maurice K.C. Ho
Department of Biochemistry and Biotechnology Research Institute
Hong Kong University of Science and Technology
Clear Water Bay, Kowloon
Hong Kong
China


Yung H. Wong
Department of Biochemistry and Biotechnology Research Institute
Hong Kong University of Science and Technology
Clear Water Bay, Kowloon
Hong Kong
China


Francesco Roselli
Department of Neurological and Psychiatric Sciences
University of Bari
Bari
Italy
/
Max Planck Institute of Psychiatry
Munich
Germany


Giovanni Defazio
Department of Neurological and Psychiatric Sciences
University of Bari
Bari
Italy


Paolo Livrea
Department of Neurological and Psychiatric Sciences
University of Bari
Bari
Italy


Emilio Jirillo
Department of Internal Medicine
Immunology and Infectious Diseases, University of Bari
National Institute for Digestive Diseases, Castellana Grotte
Bari
Italy


Thomas F. Kresina
Division of Pharmacological Therapies, Center for Substance Abuse Treatment
Substance Abuse and Mental Health Services Administration
Rockville
MD
USA


Billy Pick
Office of HIV/AIDS, United States Agency for International Development
Washington
DC
USA




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