Editors: Atta-ur-Rahman , M. Iqbal Choudhary

Frontiers in CNS Drug Discovery

Volume 1

eBook: US $44 Special Offer (PDF + Printed Copy): US $303
Printed Copy: US $281
Library License: US $176
ISSN: 1879-6656 (Print)
ISSN: 1879-6613 (Online)
ISBN: 978-1-60805-363-6 (Print)
ISBN: 978-1-60805-159-5 (Online)
Year of Publication: 2010
DOI: 10.2174/97816080515951100101

Introduction

“Frontiers in CNS Drug Discovery” is an eBook series devoted to publishing the latest and the most important advances in Central Nervous System (CNS) drug design and discovery. Eminent scientists write contributions on all areas of rational drug design and drug discovery including medicinal chemistry, in-silico drug design, combinatorial chemistry, high-throughput screening, drug targets, recent important patents, and structure-activity relationships. The eBook series should prove to be of interest to all pharmaceutical scientists involved in research in CNS drug design and discovery. Each volume is devoted to the major advances in CNS drug design and discovery. The eBook series is essential reading to all scientists involved in drug design and discovery who wish to keep abreast of rapid and important developments in the field.

Indexed in: Book Citation Index, Science Edition, Web of Science, BIOSIS Previews, EMBASE, EBSCO.

Preface

- Pp. i
Atta-ur-Rahman and M. Iqbal Choudhary
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Contributors

- Pp. ii-ix (8)
Bentham Science Publishers
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Antiretroviral Therapy and HIV-1-Associated Dementia

- Pp. 1-20 (20)
Michela Pollicita, Luigi Ronga, Valentina Svicher, Carlo Federico Perno and Stefano Aquaro

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Protective Substances Against Zinc-Induced Neuronal Death after Ischemia: Carnosine as a Target for Drug of Vascular Type of Dem

- Pp. 21-30 (10)
Masahiro Kawahara, Keiko Konoha, Tetsuya Nagata and Yutaka Sadakane

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Therapeutical Potentials of Protein Kinase C Activators as Antidementic and Cognition-Enhancing Agents

- Pp. 31-50 (20)
Miao-Kun Sun and Daniel L. Alkon

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Insulin-Like Growth Factor-1 and its Derivatives: Potential Pharmaceutical Application for Ischemic Brain Injury

- Pp. 51-75 (25)
Jian Guan

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Galantamine, a Natural Product for the Treatment of Alzheimer's Disease

- Pp. 76-105 (30)
Luis Marco and Maria do Carmo Carreiras

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Therapeutic Treatment of Alzheimer's Disease Using Metal Complexing Agents

- Pp. 106-122 (17)
Katherine A. Price, Peter J. Crouch and Anthony R. White

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Alzheimer's Disease Drug Discovery: Potential Therapeutic Strategies and Future Treatments

- Pp. 123-146 (24)
Laurent Lecanu and Vassilios Papadopoulos

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Pharmacological Treatment for Parkinson's Disease: A Continuing Evolution

- Pp. 147-155 (9)
Quincy J. Almeida and H. Christopher Hyson

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Vasopressin Antagonists as Anxiolytics and Antidepressants: Recent Developments

- Pp. 156-183 (28)
Karine Fabio, Christophe Guillon, Shi-fang Lu, Ned D. Heindel, Marvin Miller, Craig F. Ferris, Michael J. Brownstein and Carrie Gar
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Recent Developments in Anxiety Disorders

- Pp. 184-205 (22)
David M. Christmas, Geetha Menon and Sean D. Hood
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Drugs and Aggression†

- Pp. 206-223 (18)
Alberto A. Rasia-Filho, Marcia Giovenardi and Rosa M.M. de Almeida

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Antiepileptic Drug and Estradiol Neuroprotection in Epilepsy

- Pp. 224-244 (21)
Libor Velisek and Jana Veliskova

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Glucocorticoids Involvement in the Control of CNS Excitability: An Updated

- Pp. 245-283 (39)
Anna Capasso, Mariella Caputo, Mario Felice Tecce and Alberto Loizzo

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Glycine Transporter Inhibitors as Therapeutic Agents for Schizophrenia

- Pp. 284-303 (20)
Kenji Hashimoto

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Blocking Striatal Adenosine A2A Receptors: A New Strategy for Basal Ganglia Disorders

- Pp. 304-341 (38)
Christa E. Muller and Sergi Ferre

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The Astrocytic GABAA/Benzodiazepine-Like Receptor: Identifying the Joker Receptor for Benzodiazepine-Mimetic Drugs?

- Pp. 342-361 (20)
Leif Hertz and Ye Chen

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Muscarinic Acetylcholine Receptors as Novel Therapeutic Targets

- Pp. 362-377 (16)
Ada Maria Tata

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Tachykinergic System and Binding Molecules in Disease: Implication for Targeted Therapies

- Pp. 378-389 (12)
Pranela Rameshwar

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The Gastrin-Releasing Peptide Receptor as a Therapeutic Target in CNS Disorders

- Pp. 390-399 (10)
Rafael Roesler, Flavio Kapczinski, Joao Quevedo, Felipe Dal Pizzol and Gilberto Schwartsmann

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GPCR Drug Pipeline: New Compounds for CNS Diseases

- Pp. 400-412 (13)
William K. Lim

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Drugs that Act Through Membrane Receptors and Involve an Action of Inverse Agonism

- Pp. 413-429 (17)
Gabriel Barreda-Gomez and Rafael Rodriguez-Puertas

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Neurokinin 3 (NK3) Receptor Modulators for the Treatment of Psychiatric Disorders

- Pp. 430-458 (29)
Paul W. Smith and Lee A. Dawson

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Functional Interference of Dexamethasone on Some Morphine Effects: Hypothesis for the Steroid-Opioid Interaction: An Updated

- Pp. 459-496 (38)
Anna Capasso, Mariella Caputo, Mario Felice Tecce and Alberto Loizzo

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The Quest to Repair the Damaged Spinal Cord

- Pp. 497-518 (22)
Maria Teresa Moreno-Flores and Jesus Avila

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The Hypothalamus and Obesity

- Pp. 519-536 (18)
Joanne A. Harrold and Jason C.G. Halford

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Therapeutic Approach of Histamine H3 Receptors in Obesity

- Pp. 537-542 (6)
Takayuki Masaki and Hironobu Yoshimatsu

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Recent Patents on Pharmacotherapy for Alcoholism

- Pp. 543-599 (57)
Jozsef Nagy

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In Search of Novel and Therapeutically Significant Melatoninergic Ligands

- Pp. 600-610 (11)
Sejal M. Mody, Yueqing Hu, Maurice K.C.Ho and Yung H. Wong

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Voltage-Gated Sodium Channel Blockers as Immunomodulators

- Pp. 611-624 (14)
Francesco Roselli, Giovanni Defazio, Paolo Livrea and Emilio Jirillo

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Global Availability and Utilization of Medication Assisted Treatment of Drug Abuse and Dependence: An Update

- Pp. 625-637 (13)
Thomas F. Kresina and Billy Pick

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Author Index to Volume 1

- Pp. 638-639 (2)
Bentham Science Publishers
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