Editor: Xing Chen

On-Chip Pretreatment of Whole Blood by using MEMS Technology

eBook: US $24 Special Offer (PDF + Printed Copy): US $101
Printed Copy: US $89
Library License: US $96
ISBN: 978-1-60805-528-9 (Print)
ISBN: 9781-60805-147-2 (Online)
Year of Publication: 2012
DOI: 10.2174/97816080514721120101


Indexed in: Book Citation Index, Science Edition, Web of Science, Scopus, EBSCO.


With the cross-disciplinary development of MEMS technology, analytical chemistry, life sciences, electronics, informatics and so on, microfluidics technology has been in progess, which has been valued as one of the most important inventions affecting the human future. Blood is a very rare treasure, which has been widely used in clinic diagnoses, medicinal therapy, life sciences research etc. Blood is deemed so precious that is also called "red gold" because it can be sold for more than the cost of the same weight in gold. However the components of the blood is complicated, including cells, sub-cells, nucleic acid, protein, glucose, mineral ions, hormones, platelets and so on, which couldn’t be directly analyzed or used but need be pre-treated. Traditional sample pre-treatment techniques are usually performed manually, at lower integration, with time-consuming processes, and requiring large volumes of blood. The technologies of blood sample pre-treatment microfluidic chip could not only resolve the above problems of the traditional techniques, but also could potentially enable whole blood analyses for personal diagnoses and point-of-care detection. Furthermore, the technologies of blood sample pre-treatment chip could play an important role for the revolution of modern medicine.

The group of Prof. Dafu Cui has begun to study MEMS technology and microfluidics. After more than ten years, various functional microfluidic chips such as blood separation chip, DNA chip, PCR chip, PDMS sandwich type electrophoresis chip have been developed and published in many famous international journals. As soon as “DNA extraction microfluidic chip integrated with porous matrix” was published, it was highly concerned and evaluated by the French and American experts. “Whole blood sample pre-treatment integrated microfluidic chip” has been cited so many times after it was published, which was highly valued as “This is a significant step toward a true “lab on a chip” where multiple steps are combined into a single device”.

Blood sample pre-treatment microfluidic chip and its technology is on the rise, which is far from universal. The authors reviewed a large amount of literature, and combined ten years of the group’s research work to write the eBook with rich, full of examples. The readers will get a comprehensive understanding of this new technology, and also be provided the reference value for their research work. Furthermore the blood sample pre-treatment microfluidic chip technology will be promoted and further developed in the future.

Prof. Daoben Zhu
Institute of Chemistry
Chinese Academy of Sciences