Editor: Nicolas Wiernsperger

Microcirculation and Insulin Resistance

eBook: US $64 Special Offer (PDF + Printed Copy): US $148
Printed Copy: US $116
Library License: US $256
ISBN: 978-1-60805-683-5 (Print)
ISBN: 978-1-60805-057-4 (Online)
Year of Publication: 2009
DOI: 10.2174/97816080505741090101

Introduction

Insulin resistance is the main factor involved in the occurrence of the metabolic syndrome and later development of type2 diabetes. Despite decades of research on hormone's target tissues and the identification of most diverse candidates, the factors responsible for insulin resistance are still largely undefined. There is also a large discrepancy between in vitro and in vivo insulin sensitivity. Finally it is increasingly demonstrated that insulin resistance is found very early in life, long before metabolic syndrome is established. In search for commonalities, this book deals therefore with a new hypothesis considering microcirculation as one prime, possibly causal effector of insulin resistance. To present this novel hypothesis, the specificities of microvascular physiological mechanisms and the limits of interpretations of data according to the measurement techniques used are first thoroughly described. Several chapters deal with experimental and clinical investigations showing the involvement of microcirculation in insulin resistance. This book provides sound support for microcirculation being linked to insulin resistance at least in a bidirectional way. Supportive evidence suggests that microvascular dysfunction may lie upstream of insulin resistance in many of them. While this is still a hypothesis, the authors believe that there is enough data supporting it and hope that this book will stimulate researchers to provide the necessary final proofs.

Contributors

Editor(s):
Nicolas Wiernsperger
Universidade do Estado do Rio de Janeiro
Brazil




Co-Editor(s):
Eliete Bouskela
State University of Rio de Janeiro
Brazil


Luiz Guilherme Kraemer-Aguiar
State University of Rio de Janeiro
Brazil




Contributor(s):
Ramaroson Andriantsitohaina Ph.D.

Faculté de Médecine, Université d’Angers
INSERM U771, CNRS UMR
France


Wineke Bakker Ph.D.
Laboratory for Physiology
Institute for cardiovascular research, VU medical Centre
Amsterdam
The Netherlands


Daniel Bottino Ph.D.
Laboratorio de Pesquisas em Microcirculaçao
Centro Biomedico, Uniersidade do Estado do
Rio de Janeiro
Brazil


Eliete Bouskela M.D., Ph.D.
Professor, Laboratorio de Pesquisas em Microcirculaçao
Centro Biomedico, Universidade do Estado do Rio de Janeiro
Rio de Janeiro
Brazil


Robert W. Brock Ph.D.
Dept of Physiology and Pharmacology
Center for Cardiovascular and Respiratory Sciences, West Virginia University Health Sciences Center
Morgantown
WV
USA


Jean-Frederic Brun Ph.D.
INSERM ERI25 Muscle et Pathologies
Service Central de Physiologie Clinique, CERAMM, CHU Lapeyronie
Montpellier
France


Michiel P. de Boer M.D.
Dept of Internal Medicine
Institute for Cardiovascular Research, VU Medical Centre
Amsterdam
The Netherlands


Renate T. de Jongh M.D., Ph.D.
Dept of Internal Medicine
Institute for Cardiovascular Research, VU Medical Centre
Amsterdam
The Netherlands


Etto C. Eringa Ph.D.
Laboratory for Physiology
Institute for cardiovascular research, VU medical Centre,
Amsterdam
The Netherlands


Jefferson Frisbee
Dept of Physiology and Pharmacology, Center for Cardiovascular and Respiratory Sciences
West Virginia University Health Sciences Center
Morgantown
WV
USA


D. Neil Granger Ph.D.
Dept of Molecular and Cellular Physiology
LSU Health Sciences Center
Shreveport
LA
USA


Börje Haraldsson Ph.D.
Dept of Molecular and Clinical Medicine,Nephrology
Institute of Medicine , University of Gothenburg
Gothenburg
Sweden


Richard G IJzerman M.D., Ph.D.
Dept of Internal Medicine
Institute for Cardiovascular Research, VU Medical Centre
Amsterdam
The Netherlands


L. Guilherme Kraemer-Aguiar M.D., Ph.D.
Laboratorio de Pesquisas em Microcirculaçao, Centro Biomedico
Universidade do Estado do Rio de Janeiro
Rio de Janeiro
Brazil


Maria Carmen Martinez Ph.D.
Faculté de Médecine, Université d’Angers
INSERM U771, CNRS UMR 6214
France


Rick I. Meijer M.D.
Dept of Internal Medicine
Institute for Cardiovascular Research, VU Medical Centre
Amsterdam
The Netherlands


Jacques Mercier M.D., Ph.D.
INSERM ERI25 Muscle et Pathologies
Service Central de Physiologie Clinique, CERAMM, CHU Lapeyronie
Montpellier
France


Timothy I Musch Ph.D.
Depts of Kinesiology, Anatomy and Physiology
Manhattan
Kansas
USA


David C. Poole Ph.D.
Depts of Kinesiology, Anatomy and Physiology
Manhattan
Kansas
USA


Eric Raynaud de Mauverger Ph.D.
INSERM ERI25 Muscle et Pathologies
Service Central de Physiologie Clinique, CERAMM, CHU Lapeyronie
Montpellier
France


Peter Rösen Ph.D.
German Diabetes Research Center,
Dusseldorf
Germany


Renate Rösen Ph.D.
Institute of Pharmacology, University of Cologne
Germany


Mathieu Sardinoux Ph.D.
INSERM ERI25 Muscle et Pathologies
Service Central de Physiologie Clinique, CERAMM, CHU Lapeyronie
Montpellier
France


Eric H. Serné M.D., Ph.D.
Dept of Internal Medicine
Institute for Cardiovascular Research, VU Medical Centre
Amsterdam
The Netherlands


Georg Singer M.D.
Dept of Pediatric Surgery
Medical University of Graz
Graz
Austria


Emmanuelle Varlet-Marie Ph.D.
Laboratoire de Biophysique et Bioanalyses
Faculté de Pharmacie, Université de Montpellier I
Montpellier
France


Nicolas F. Wiernsperger Ph.D.
NSERM U870, INSA Lyon
Villeurbanne
France
/
Laboratorio de Pesquisas em Microcirculaçao
Rio de Janeiro
Brazil




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