Editor: Nicolas Wiernsperger

Microcirculation and Insulin Resistance

eBook: US $64 Special Offer (PDF + Printed Copy): US $148
Printed Copy: US $116
Library License: US $256
ISBN: 978-1-60805-683-5 (Print)
ISBN: 978-1-60805-057-4 (Online)
Year of Publication: 2009
DOI: 10.2174/97816080505741090101


Insulin resistance is the main factor involved in the occurrence of the metabolic syndrome and later development of type2 diabetes. Despite decades of research on hormone's target tissues and the identification of most diverse candidates, the factors responsible for insulin resistance are still largely undefined. There is also a large discrepancy between in vitro and in vivo insulin sensitivity. Finally it is increasingly demonstrated that insulin resistance is found very early in life, long before metabolic syndrome is established. In search for commonalities, this book deals therefore with a new hypothesis considering microcirculation as one prime, possibly causal effector of insulin resistance. To present this novel hypothesis, the specificities of microvascular physiological mechanisms and the limits of interpretations of data according to the measurement techniques used are first thoroughly described. Several chapters deal with experimental and clinical investigations showing the involvement of microcirculation in insulin resistance. This book provides sound support for microcirculation being linked to insulin resistance at least in a bidirectional way. Supportive evidence suggests that microvascular dysfunction may lie upstream of insulin resistance in many of them. While this is still a hypothesis, the authors believe that there is enough data supporting it and hope that this book will stimulate researchers to provide the necessary final proofs.


- Pp. i-ii (2)
Nicolas Wiernsperger, Eliete Bouskela, Luiz Guilherme Kraemer-Aguiar
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- Pp. iii-iv (2)
Nicolas Wiernsperger, Eliete Bouskela, Luiz Guilherme Kraemer-Aguiar
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Microcirculation: Structural and Functional Specificities

- Pp. 1-13 (13)
Eliete Bouskela, Daniel Bottino, Nicolas Wiernsperger
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Techniques to Measure Microcirculatory Parameters in Insulin Resistant States in Humans

- Pp. 14-30 (17)
Luiz Guilherme Kraemer-Aguiar, Eliete Bouskela
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Microvascular Dysfunction in Insulin Resistance

- Pp. 31-40 (10)
Jefferson C. Frisbee, Robert W. Brock
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Microvascular Dysfunction: Potential Role in the Pathogenesis of Obesity-Associated Hypertension and Insulin Resistance

- Pp. 41-54 (14)
Erik H Serne, Rick I Meijer, Michiel P de Boer, Renate T de Jongh, Richard G IJzerman, Wineke Bakker, Etto C Eringa
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Inflammatory Responses to Obesity and Insulin Resistance

- Pp. 55-69 (15)
Georg Singer, D. Neil Granger
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Oxidative Stress and Microvascular Function in Insulin- Resistant States

- Pp. 70-84 (15)
P. Rosen, R. Rosen
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Microalbuminuria and Insulin Resistance

- Pp. 85-90 (6)
Borje Haraldsson
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Importance of Microparticles in Microcirculation and Diseases

- Pp. 91-98 (8)
Maria Carmen Martinez, Ramaroson Andriantsitohaina
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Hemorheology in Insulin Resistance

- Pp. 99-106 (8)
Jean-Frederic Brun, Emmanuelle Varlet-Marie, Ikram Aloulou, Mathieu Sardinoux, Eric Raynaud de Mauverger, Jacques Mercier
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Post-Myocardial Infarction Insulin Resistance: A Sentinel Role for the Muscle Microcirculation

- Pp. 107-118 (12)
David C. Poole, Timothy I. Musch
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Is Defective Microcirculation Responsible for Insulin Resistance? PART 1: Microvascular Dysfunction and Insulin Resistance are Linked: Evidences from Clinical Observations

- Pp. 119-139 (21)
Nicolas Wiernsperger
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Is Defective Microcirculation Responsible for Insulin Resistance? PART 2. Insulin and Microcirculation: Physiology and Pathophysiology

- Pp. 140-155 (16)
Nicolas Wiernsperger
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Is Defective Microcirculation Responsible for Insulin Resistance? PART 3. Microvascular Defects Potentially Leading to Insulin Resistance

- Pp. 156-167 (12)
Nicolas Wiernsperger
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.Nanoscience Applications in Diabetes Treatment.
.Frontiers in Clinical Drug Research – Diabetes and Obesity.
.Diabesity: A Multidisciplinary Approach.
.Pharmacological and Molecular Perspectives on Diabetes.