Editors: Atta-ur-Rahman, Mohammad Iqbal Choudhary

Drug Design and Discovery in Alzheimer’s Disease

Republished Version of Frontiers in Drug Design and Discovery Volume 6

eBook: US $165 Special Offer (PDF + Printed Copy): US $317
Printed Copy: US $235
Library License: US $660
ISSN: 1574-0889 (Print)
ISSN: 2212-1064 (Online)
ISBN: 978-0-12-803959-5 (Print)
ISBN: 978-012-803960-1 (Online)
Year of Publication: 2014
DOI: 10.1016/c2014-0-04317-1

Introduction

“Frontiers in Drug Design and Discovery” is an Ebook series devoted to publishing the latest and the most important advances in drug design and discovery. Eminent scientists write contributions on all areas of rational drug design and drug discovery including medicinal chemistry, in-silico drug design, combinatorial chemistry, high-throughput screening, drug targets, and structure-activity relationships. The Ebook series should prove to be of interest to all the pharmaceutical scientists involved in research in drug design and discovery. Each volume is devoted to the major advances in drug design and discovery. The Ebook series is essential reading to all scientists involved in drug design and discovery who wish to keep abreast of rapid and important developments in the field.

The sixth volume of this Ebook series focuses on drug discovery and design strategies for the treatment of Aheimer’s Diseases and related neurodegenerative disorders.

Indexed in: Book Citation Index, Science Edition, BIOSIS Previews, Scopus, EMBASE, EBSCO, Ulrich's Periodicals Directory.

Preface

- Pp. i-iii (3)
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List of Contributors

- Pp. iv-xi (8)
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Pharmacotherapy of Alzheimer's Disease: Current State and Future Perspectives

- Pp. 3-39 (37)
Jan Korabecny, Filip Zemek, Ondrej Soukup, Katarina Spilovska, Kamil Musilek, Daniel Jun, Eugenie Nepovimova and Kamil Kuca

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Challenges in Designing Therapeutic Agents for Treating Alzheimer’s Disease-from Serendipity to Rationality

- Pp. 40-141 (102)
Umer Rashid and Farzana L. Ansari

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Enzyme Inhibitors Involved in the Treatment of Alzheimer’s Disease

- Pp. 142-198 (57)
Vageesh Revadigar, Raza Murad Ghalib, Vikneswaran Murugaiyah, Mohamed A. Embaby, Ali Jawad, Sayed Hasan Mehdi, Rokiah Hashim and Othman Sulaiman

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Towards Small Molecules as Therapies for Alzheimer’s Disease and Other Neurodegenerative Disorders

- Pp. 199-290 (92)
Omar Aziz, Roland W. Bürli, David F. Fischer, Julie Frearson and Michael D. Wall

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Multifunctional Enzyme Inhibition for Neuroprotection - A Focus on MAO, NOS, and AChE Inhibitors

- Pp. 291-365 (75)
Jacques Joubert, Jacobus P. Petzer, Louis H.A. Prins, Benjamin P. Repsold and Sarel F. Malan

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Specific Cholinesterase Inhibitors: A Potential Tool to Assist in Management of Alzheimer Disease

- Pp. 366-386 (21)
Nigel H. Grieg, Mohammad A. Kamal, Nasimudeen R. Jabir, Shams Tabrez, Faizul H. Nasim, Adel M. Abuzenadah and Gjumrakch Aliev

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Role of Acetylcholinesterase Inhibitors and Alzheimer Disease

- Pp. 387-425 (39)
Zafar Saied Saify and Nighat Sultana

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Research Strategies Developed for the Treatment of Alzheimer’s Disease. Reversible and Pseudo-Irreversible Inhibitors of Acetylcholinesterase: Structure-Activity Relationships and Drug Design

- Pp. 426-477 (52)
Mauricio Alcolea-Palafox, Paloma Posada-Moreno, Ismael Ortuño- Soriano, José L. Pacheco-del-Cerro, Carmen Martínez-Rincón, Dolores Rodríguez-Martínez and Lara Pacheco-Cuevas

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Modulation of BACE1 Activity as a Potential Therapeutic Strategy for Treating Alzheimer’s Disease

- Pp. 478-517 (40)

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BACE1 Inhibitors: Attractive Therapeutics for Alzheimer’s Disease

- Pp. 518-546 (29)
Boris Decourt, MiMi Macias, Marwan Sabbagh and Abdu Adem

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Combining BACE1 Inhibition with Metal Chelation as Possible Therapy for Alzheimer’s Disease

- Pp. 547-565 (19)
Maged M. Henary, Tyler L. Dost, Eric A. Owens and Surendra Reddy Punganuru

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Somatostatin Receptor-4 Agonists as Candidates for Treatment of Alzheimer’s Disease

- Pp. 566-597 (32)
Karin E. Sandoval, Kenneth A. Witt, A. Michael Crider and Maria Kontoyianni

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Neprilysin Inhibitors Provide Insight into its Specificity and Therapeutic Potential

- Pp. 598-622 (25)
Darrick Pope and Michael Cascio

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Targeting the GSK3β/β-catenin Signaling to Treat Alzheimer´s Disease: Plausible or Utopic?

- Pp. 623-642 (20)
Fares Zeidán-Chuliá and José Cláudio Fonseca Moreira

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Targets and Small Molecules Against Tauopathies. Part 1: From Genes to Soluble, Aggregation-Prone Tau Proteins

- Pp. 643-715 (73)
Pierfausto Seneci

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Nanomedicine Based Drug Targeting in Alzheimer’s Disease: High Impact of Small Carter

- Pp. 716-739 (24)
Mohammad Zaki Ahmad, Sohail Akhter, Ziyaur Rahman, Javed Ahmad, Iqbal Ahmad and Farhan Jalees Ahmad

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Index

- Pp. 740-766 (27)
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