Editors: Raman Singh, Antresh Kumar, Kuldeep Singh

2-Deoxy-D-Glucose: Chemistry and Biology

eBook: US $59 Special Offer (PDF + Printed Copy): US $102
Printed Copy: US $72
Library License: US $236
ISBN: 978-981-5305-16-6 (Print)
ISBN: 978-981-5305-15-9 (Online)
Year of Publication: 2024
DOI: 10.2174/97898153051591240101

Introduction

2-Deoxy-D-Glucose: Chemistry and Biology extensively examine 2-deoxy-D-glucose (2DG), a glucose analog with profound biomedical and therapeutic potential. This detailed resource covers 2DG's chemical structure, methods of synthesis, and its pivotal roles in diagnostics and therapeutics. This book provides a comprehensive overview of the compound’s multifaceted uses, from antiviral applications to its emerging role in cancer treatment.

Key Features

  • - Comprehensive coverage of 2DG synthesis, structure, and characterization.
  • - Insights into 2DG’s diagnostic and therapeutic potential, including cancer and antiviral applications.
  • - Exploration of its role in the Warburg effect and glycosylation inhibition.
  • - Discussion on 2DG’s clinical applications, including COVID-19 treatments.

Readership

Organic and medicinal chemists, oncologists, virologists, pharmaceutical researchers, and graduate students.

Foreword

- Pp. i
Ravi Bhushan
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Preface

- Pp. ii-iii (2)
Raman Singh, Antresh Kumar, Kuldeep Singh
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List of Contributors

- Pp. iv-v (2)

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2-Deoxy-D-Glucose: Chemical Structure and Properties

- Pp. 1-11 (11)
Raman Singh, Kuldeep Singh*

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Methods and Procedures for the Synthesis of 2- Deoxy-D-Glucose

- Pp. 12-28 (17)
Raman Singh, Vidushi Gupta, Kuldeep Singh*

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Characterization of 2-Deoxy-D-glucose

- Pp. 29-50 (22)
Ramji Lal Yadav*, Neeru Singh, S. N. Karaiya, Rahul Dev, Anil Kumar

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[ 18F]Fluoro Analogue of D-Glucose: A Chemistry Perspective

- Pp. 51-69 (19)
Mohd Faheem, Vaibhav Pandey, Manish Dixit*

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Antiviral Potential of 2-DG Used in Different Viral Infections

- Pp. 70-83 (14)
Shaurya Prakash, Minakshi, Hemlata Kumari, Antresh Kumar*

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2-Deoxy-D-Glucose and its Derivatives: Dual Role in Diagnostics and Therapeutics

- Pp. 84-128 (45)
Anil Kumar*, Krishnendu Barik

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2-Deoxy-D-Glucose as a Potential Antiviral and Anti-COVID-19 Drug

- Pp. 129-156 (28)
Pandeeswaran Santhoshkumar, Arunagiri Sivanesan Aruna Poorani, Mohamed Ibrahim Mohamed Ismail, Palaniswamy Suresh*

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Prospects for Cancer Diagnosis, Treatment, and Surveillance: [18F]FDG PET/CT and Innovative Molecular Imaging to Direct Immunotherapy in Cancer

- Pp. 157-182 (26)
Juhi Rais, Manish Ora, Manish Dixit*

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2-Deoxy-D-Glucose as an Emerging Chemotherapeutic Agent in Cancer Management

- Pp. 183-202 (20)
Ashutosh Singh, Ravinsh Kumar, Amrita Srivastava*

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2-Deoxy-D-Glucose: A Glycolysis Inhibitor in the Treatment of Cancer

- Pp. 203-231 (29)
Arunagiri Sivanesan Aruna Poorani, Mohamed Ibrahim Mohamed Ismail, Pandeeswaran Santhoshkumar, Palaniswamy Suresh*

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Dual Role of 2-Deoxy-D-Glucose in Seizure Modulation

- Pp. 232-241 (10)
Shaurya Prakash, Kuldeep Singh, Antresh Kumar*

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Lipinski’s Rule of Five

- Pp. 242-246 (5)
Raman Singh, Kuldeep Singh*

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Subject Index

- Pp. 247-252 (6)
Raman Singh, Antresh Kumar, Kuldeep Singh
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