Author: Juan Bernal

Thyroid and Brain: Understanding the Actions of Thyroid Hormones in Brain Development and Function

eBook: US $59 Special Offer (PDF + Printed Copy): US $101
Printed Copy: US $71
Library License: US $236
ISBN: 978-981-5274-23-3 (Print)
ISBN: 978-981-5274-22-6 (Online)
Year of Publication: 2024
DOI: 10.2174/97898152742261240101

Introduction

This comprehensive textbook offers an in-depth exploration of how thyroid hormones influence brain development and function, particularly on cellular and molecular mechanisms. Readers will find current insights into the complex interplay between the thyroid and neurological systems, making it a valuable resource for researchers, advanced learners and clinicians in the fields of endocrinology, neuroscience, and developmental biology.

The book starts with a review of thyroid physiology, setting the stage for subsequent chapters that cover specific topics such as the impact of maternal thyroid hormones on fetal brain development and the effects of iodine deficiency. From here, the book progresses to cover the regulation of brain gene expression, neuronal and glial cell differentiation, and myelination by thyroid hormones, and how thyroid hormones shape the brain. Finally, the book addresses the link between thyroid dysfunction and mood disorders.

Key features

  • - A thorough examination of the historical and the latest research findings through 14 chapters
  • - Clear explanations of molecular pathways
  • - Emphasis on both theoretical knowledge and practical applications
  • - Detailed and research-focused content scientific references for further reading

This textbook is an essential resource for pharmacy students, specialist assistants, and anyone pursuing a career in clinical pharmacy.

Readership

Medical students, residents, researchers (neuroscience and developmental biology), and healthcare professionals (neurologists and endocrinologists) who need to understand the regulation of brain development by thyroid hormones and the treatment of thyroid-related neurological conditions.


Foreword

- Pp. i
Samuel Refetoff
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Preface

- Pp. ii
Juan Bernal*
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Acknowledgements

- Pp. iii
Juan Bernal*
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Dedication

- Pp. iv
Juan Bernal*
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An Introduction to Thyroid Physiology

- Pp. 1-24 (24)
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Congenital Hypothyroidism

- Pp. 25-38 (14)
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Deiodinases in the Brain

- Pp. 39-64 (26)
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Unraveling the Role of Maternal Thyroid Hormones on Fetal Development

- Pp. 65-82 (18)
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Endemic Goiter and Cretinism: Pathophysiology of Iodine Deficiency

- Pp. 83-98 (16)
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Cellular Transporters for Thyroid Hormones

- Pp. 99-118 (20)
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The Allan-Herndon-Dudley Syndrome: Pathophysiology and Mouse Models of MCT8 Deficiency

- Pp. 119-143 (25)
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Thyroid Hormone Receptors in the Brain: Distribution and Deletion Effects on Brain Structure and Behavior

- Pp. 144-165 (22)
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Pathophysiology and Mouse Models of Thyroid Hormone Resistance Syndromes: A Focus on the Brain

- Pp. 166-179 (14)
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Thyroid Hormone-Regulated Genes in the Brain

- Pp. 180-201 (22)
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Actions of Thyroid Hormones on Myelination

- Pp. 202-218 (17)
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How Thyroid Hormones Shape the Brain

- Pp. 219-257 (39)
Juan Bernal*

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Mechanisms of Thyroid Hormone Action on Adult Neurogenesis

- Pp. 258-265 (8)
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Thyroid Hormones and Mood Disorders

- Pp. 266-275 (10)
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Subject Index

- Pp. 276-281 (6)
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