Andrographolide and its Analogs: Botanical Sources, Phytochemistry, Pharmacology, and Biotechnology

This book provides an in-depth and comprehensive overview of andrographolides and their analogues, highlighting their botanical origins, phytochemistry, pharmacological properties, and biotechnological applications. It explores the isolation, purification, and spectroscopic characterization of andrographolides from natural sources, emphasizing their therapeutic potential in antidiabetic studies and other medicinal uses. The book also explains cultivation techniques, agronomic strategies for Andrographis species, genetic improvements, and in vivo extraction methods aimed at enhancing andrographolide yields, with a focus on commercial cultivation and export strategies.

Dedicated chapters, contributed by experts, discuss the ethnobotanical significance of Andrographis species, traditional medicinal formulations, and advanced biotechnological interventions for conservation and utilization. Recent breakthroughs in understanding andrographolides' biosynthesis, metabolism, safety aspects, and promising applications in treating diabetes, cancer, inflammation, liver diseases, and neurological disorders are also covered. Readers will gain insight into how andrographolide analogues can be developed as "lead molecules" for creating next-generation phytodrugs.

Key Features:

- Provides a comprehensive account of andrographolide-producing plant sources and their phytochemical and pharmacological properties.
- Explores the role of biotechnology in enhancing andrographolide production through in vivo and in vitro methods.
- Highlights the therapeutic efficacy of andrographolides and analogues in antidiabetic, anticancer, hepatoprotective, and anti-inflammatory drug development.
- Discusses cutting-edge advancements in the biosynthesis and semisynthetic derivatives of andrographolides.
- Covers cultivation, agronomic techniques, and genetic improvements to optimize andrographolide production for commercial applications.

This book is a valuable resource for researchers, pharmacologists, biotechnologists, and biomedical professionals focused on natural product-based drug discovery involving andrographolide.

Readership

Pharmaceutical chemists, pharmacologists, researchers and biotechnologists.

Editor(s):

S. Karuppusamy
Department of Botany, The Madura College
Madurai-625011
Tamil Nadu, India

Vinod K. Nelson
Centre for Global Health Research
Saveetha Medical College and Hospital
Saveetha Institute of Medical and Technical Sciences
Chennai 602105, Tamil Nadu
India

T. Pullaiah
Department of Botany
Andhra Pradesh
India

Contributor(s):

Amit Upadhyay
Amity Institute of Pharmacy
Amity University Gwalior
Madhya Pradesh 474005
India

Alagusundaram Muthumanickam
Department of Pharmaceutics
School of Pharmacy, ITM University, Gwalior
Madhya Pradesh
India

Arijit Chaudhuri
Department of Pharmaceutics
School of Pharmacy, ITM University, Gwalior
Madhya Pradesh
India

Alugubelli Gopi Reddy
Department of Pharmaceutical Chemistry
Sana College of Pharmacy, Kodad, Suryapet Dist
Telangana
India

Angala Parameswari Sundaramoorthy
Department of Pharmaceutical Analysis
Ratnam Institute of Pharmacy, Pidathapolur, Nellore
Andhra Pradesh
India

Arghya Kusum Dhar
School of Pharmacy
The Neotia University, Sarisha
West Bengal-743368
India

Beere Vishnusai
Department of Pharmacology and Toxicology
National Institute of Pharmaceutical Education and Research, Hajipur
Bihar
India

Beda Durga Prasad
Department of Pharmaceutical Chemistry
GITAM School of Pharmacy, Hyderabad
Telangana
India

B. Shivananthini
Centre for Plant Biotechnology
Department of Botany, St. Xavier’s College (Autonomous), Palayamkottai – 627002
Tamil Nadu
India

Chandrasekaran
Department of Pharmaceutical Chemistry
Krishna Teja Pharmacy College, Tirupati
Andhra Pradesh
India

Chitikela P. Pullaiah
Department of Pharmacology
Siddha Central Research Institute, Central Council for Research in Siddha, Ministry of AYUSH
Chennai, 600106
India

Divya Kallingil Gopi
Department of Pharmacognosy
Siddha Central Research Institute (Central Council for Research in Siddha, Ministry of AYUSH, Government of India) Chennai 600106
Tamil Nadu
India

Goli Venkateswarlu
Department of Pharmaceutics
School of Pharmacy, ITM University, Gwalior
Madhya Pradesh
India

Gopinath Papichettypalle
Department of Pharmaceutical Chemistry
GITAM School of Pharmacy, GITAM University Hyderabad Campus, Rudraram, Sangareddy
Telangana State
India

Geetha Birudala
Faculty of Pharmacy
Dr. M.G.R. Educational and Research Institute
Velappanchavadi, Chennai
India

Hemanth Kumar
Department of Pharmacology
School of Pharmacy, Anurag University, Ghatkesar, Medchal, Hyderabad
Telangana 500088
India

Hari Hara sudan
Centre for Global Health Research
Saveetha Medical College and Hospital, Saveetha Institute of Medical and Technical Sciences, Chennai 602105
Tamil Nadu
India

I. Silvia Juliet
Centre for Plant Biotechnology
Department of Botany, St. Xavier’s College (Autonomous), Palayamkottai – 627002
Tamil Nadu
India

Jamal Basha Dudekula
Amity Institute of Pharmacy
Amity University Gwalior
Madhya Pradesh 474005
India

Juturu Mastanaiah
Department of Pharmacology
Balaji College of Pharmacy, Anantapur
Andhra Pradesh
India

Jayaraman Rajangam
AMITY Institute of Pharmacy
AMITY University, Lucknow Campus
Uttar Pradesh-226010
India

Kona Karunya
Department of Pharmacology
Bojjam Narasimhulu College of Pharmacy, Saidabad
Hyderabad
India

Kola Venu
Seva Shikshan Prasarak Mandal's Dr. N.J. Paulbudhe College of Pharmacy
Vasant Tekadi, Savedi, Ahmed Nagar
Maharashtra
India

Kranthi Kumar Kotha
Departement of Pharmaceutics
College of Pharmaceutical Sciences, Dayananda Sagar University, Bengaluru
Karnataka 560078
India

K. Balaram Kumar
Department of Pharmaceutical Analysis
School of Pharmacy, College of Health and Medical Science (CHMS), Haramaya University
Harar
Ethiopia

L. Baskaran
Department of Botany
Government Arts College (Autonomous), Salem
Tamil Nadu 636007
India

Lakshman Kumar Dogiparthi
Department of Pharmacognosy
MB School of Pharmaceutical Sciences, Mohan Babu University, Tirupati
Andhra Pradesh
India

Mopuri Deepa
Departement of Pharmaceutical Chemistry
Annamacharya College of Pharmacy, Razampet
Andhra Pradesh
India

Mohana Vamsi Nuli
Centre for Global Health Research
Saveetha Medical College and Hospital, Saveetha Institute of Medical and Technical Sciences, Chennai 602105
Tamil Nadu
India

Manohar Reddy
Department of Pharmacology
P. Rami Reddy Memorial College of Pharmacy
Kadapa, Andhra Pradesh
India

Moturi Anvesh Raj
JSS Academy of Higher Education & Research
Rocklands, Ooty, Nilgiris
Tamil Nadu-643001
India

M. Johnson
Centre for Plant Biotechnology
Department of Botany, St. Xavier’s College (Autonomous), Palayamkottai – 627002
Tamil Nadu
India

Medagam Tejaswini Reddy
Department of Biotechnology
Chaitanya Bharathi Institute of Technology, Hyderabad
Telangana
India

N. Janakiraman
Department of Botany
The Madura College, Madurai-625011
Tamil Nadu
India

Nilesh Yadav Jadhav
Seva Shikshan Prasarak Mandal's Dr. N.J. Paulbudhe College of Pharmacy
Vasant Tekadi, Savedi, Ahmed Nagar
Maharashtra
India

Narayanan Kannan
Department of Pharmacognosy
Siddha Central Research Institute (Central Council for Research in Siddha, Ministry of AYUSH, Government of India) Chennai 600106
Tamil Nadu
India

Nemallapalli Yamini
Department of Pharmacology
JNTUA-OTRI, Jawaharlal Nehru Technological University
Antnatapur-515001, Andhra Pradesh
India

Naveen Sharma
Amity Institute of Pharmacy
Amity University Gwalior
Madhya Pradesh 474005
India

Namrata Mishra
Department of Pharmaceutics
School of Pharmacy, ITM University
Gwalior, Madhya Pradesh
India

Narahari N. Palei
AMITY Institute of Pharmacy
AMITY University Lucknow Campus
Uttar Pradesh-226010
India

Nazemoon Reddy
Bharat Institute of Technology
Magalpalli, Ibrahimpatnam, Hyderabad
Telangana 501510
India

Nem Kumar Jain
Department of Pharmaceutics
School of Pharmacy, ITM University, Gwalior
Madhya Pradesh
India

N. Karmegam
Department of Botany
Government Arts College (Autonomous), Salem
Tamil Nadu 636007
India

P. Bharath Simha Yadav
Department of Botany
The Madura College, Madurai-625011
Tamil Nadu
India

Phani Deepika Polampalli
Department of Biotechnology
MNR College of Pharmacy, Sangareddy 502294
Telangana State
India

Panga Shyam
Seva Shikshan Prasarak Mandal's Dr. N.J. Paulbudhe College of Pharmacy
Vasant Tekadi, Savedi, Ahmed Nagar
Maharashtra
India

Priyanka Keshri
Department of Pharmaceutics
School of Pharmacy, ITM University, Gwalior
Madhya Pradesh
India

P. Divya Bargavi
Department of Pharmacognosy
JSS College of Pharmacy, JSS Academy of Higher Education and Research
Ooty, Nilgiris, Tamil Nadu
India

Praveen Kumar Kusuma
Department of Pharmaceutical Chemistry
School of Pharmaceutical Sciences, Govt. of NCT of Delhi, Delhi Pharmaceutical Sciences and Research University (DPSRU)
Mehrauli-Badarpur Road
India

Radha Rai
Department of Pharmaceutical Chemistry
Krishna Teja Pharmacy College, Tirupati
Andhra Pradesh
India

Ravishankar Ram Mani
Faculty of Pharmaceutical Sciences
UCSI University, Cheras
Kuala Lumpur 56000
Malaysia

Ravilla Jyothsna Naidu
Department of Pharmacology
Raghavendra Institute of Pharmaceutical Education and Research (RIPER) - Autonomous, Anantapur
Andhra Pradesh
India

S. Karuppusamy
Department of Botany
The Madura College, Madurai-625011
Tamil Nadu
India

Sunil Kumar Koppala Narayana
Department of Pharmacognosy
Siddha Central Research Institute (Central Council for Research in Siddha, Ministry of AYUSH, Government of India) Chennai 600106
Tamil Nadu
India

Suryavanshu Roshini
Seva Shikshan Prasarak Mandal's Dr. N.J. Paulbudhe College of Pharmacy
Vasant Tekadi, Savedi, Ahmed Nagar
Maharashtra
India

Sasikala Chinnappan
Faculty of Pharmaceutical Sciences
UCSI University, Cheras
Kuala Lumpur 56000
Malaysia

Siddhartha Lolla
Department of Pharmacology
GITAM School of Pharmacy, Gandhi Institute of Technology and Management Deemed to be University
Hyderabad, Telangana
India

Saijyothi Ausali
MNR College of Pharmacy
MNR Higher Education and Research Academy Campus, MNR Nagar
Sangareddy-502294
India

Sheik Nasar Ismail
Department of Pharmacology
East Point College of Pharmacy, East Point Group of Institutions
Jnana Prabha Campus, Bengaluru
India

Sunkara Surya Lakshmi
Srinivasarao College of Pharmacy
Visakhapatnam
Andhra Pradesh-530041
India

Shaik Shakir Basha
Centre for Global Health Research
Saveetha Medical College and Hospital, Saveetha Institute of Medical and Technical Sciences
Chennai 602105, Tamil Nadu
India

Sandeep Kanna
Department of Pharmacology, GITAM School of Pharmacy
Gandhi Institute of Technology and Management Deemed to be University
Hyderabad, Telangana
India

Srilakshmi Bada Venkatappa Gari
Faculty of Pharmaceutical Sciences
Jawaharlal Nehru Technological University Anantapur (JNTUA), Anantapur
Andhra Pradesh
India

S.P. Preethi Priyadharshni
Department of Pharmaceutical Analysis
School of Pharmacy, College of Health and Medical Science (CHMS), Haramaya University
Harar
Ethiopia

S. Preethi
Centre for Plant Biotechnology
Department of Botany, St. Xavier’s College (Autonomous), Palayamkottai – 627002
Tamil Nadu
India

T. Pullaiah
Department of Botany
Sri Krishnadevaraya University, Anantapur 515003
Andhra Pradesh
India

T.S. Mohamed Saleem
College of Pharmacy
Riyadh ELM University
Riyadh
Kingdom of Saudi Arabia

Vinod K. Nelson
Centre for Global Health Research
Saveetha Medical College and Hospital, Saveetha Institute of Medical and Technical Sciences, Chennai 602105
Tamil Nadu
India

Vinyas Mayasa
Department of Pharmacology
GITAM School of Pharmacy, Gandhi Institute of Technology and Management Deemed to be University, Hyderabad
Telangana
India

Vijetha Pendyala
Department of Pharmacognosy and Phytochemistry
Chebrolu Hanumaiah Institute of Pharmaceutical Sciences, Guntur
Pradesh
India

Vijeta Bhattacharya
Department of Pharmaceutics
School of Pharmacy, ITM University
Gwalior, Madhya Pradesh
India

V. Soundarya
Department of Botany
Government Arts College (Autonomous), Salem
Tamil Nadu 636007
India

Vidyarani George
Centre for Plant Biotechnology
Department of Botany, St. Xavier’s College (Autonomous), Palayamkottai – 627002
Tamil Nadu
India

Varimadugu Aruna
Department of Biotechnology
Chaitanya Bharathi Institute of Technology, Hyderabad
Telangana
India

Vadakavila Geethikalal
Department of Biotechnology
Chaitanya Bharathi Institute of Technology, Hyderabad
Telangana
India

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