The NLRP3 Inflammasome: An Attentive Arbiter of Inflammatory Response

Inflammation triggers specific metabolic pathways and if not resolved, translates into several painful diseases such as rheumatoid arthritis, lupus, Alzheimer’s disease, cardiovascular disorders and psoriasis. Various processes have been explored to understand the factors behind inflammation and consequently, many mechanisms have been examined to suppress it. The nucleotide-binding domain like receptor 3 (NLRP3) inflammasome is an example of such factors which is responsible for triggering sterile and microbe induced inflammation. Studies of genetic variants of the related gene have revealed insights into the mRNA expression pathways that may help researchers to identify crucial disease mechanisms.

This book is a review of the scientific findings of distinguished scholars who have studied NLRP3 inflammasome activation and its contribution in worsening the outcomes of inflammatory disorders.

This collection of chapters covers many aspects of the multifaceted role of NLRP3 inflammasome. Beginning with airway inflammation and fibrosis, it progresses to explore its involvement in pulmonary hypertension, heart diseases, tuberculosis, cardiovascular complications, and childhood asthma. Additionally, it examines the inflammasome's impact on protozoan parasitic infections and neuropathic pain. The chapters not only elucidate the intricate mechanisms of NLRP3 activation but also discuss potential inhibitors and therapeutic targets. Readers will gain a comprehensive understanding of the NLRP3 inflammasome's diverse implications across different physiological contexts. The book includes references making this book a valuable treatise of insights for researchers, clinicians, and healthcare professionals.

Readership:

Researchers, clinicians, and healthcare professionals.

Editor(s):

Puneetpal Singh
Department of Human Genetics
Punjabi University
Patiala, Punjab
India

Contributor(s):

Anju Jaiswal
Department of Zoology
MMV, Banaras Hindu University
Varanasi-221002
India

Asha Kumari
Department of Pathology
University of Alabama at Birmingham
USA

Abhinav Kanwal
Department of Pharmacology
All India Institute of Medical Sciences, Bathinda
Punjab
India

Aamir Khan
Department of Pharmacology
School of Pharmaceutical Education and Research, Jamia Hamdard
New Delhi-110062
India

Agnès Hamzaoui
Tunis El Manar University, Medicine Faculty of Tunis, Department of Paediatric and Respiratory Diseases, Abderrahman Mami Hospital, Pavillon B, Ariana, Research Laboratory 19SP02 “Chronic Pulmonary Pathologies: From Genome to Management”
Tunisia

Anubrato Pal
Department of Pharmacology and Toxicology
National Institute of Pharmaceutical Education and Research (NIPER)
Kolkata 700054, West Bengal
India

Ashutosh Kumar
Department of Pharmacology and Toxicology
National Institute of Pharmaceutical Education and Research (NIPER)-SAS Nagar, Mohali
Punjab, 160062
India

Anchal Arora
Department of Pharmacology
All India Institute of Medical Sciences, Bathinda
Punjab
India

Ashif Iqubal
Department of Pharmacology
School of Pharmaceutical Education and Research, Jamia Hamdard
New Delhi-110062
India

Adekunle Babajide Rowaiye
Department of Agricultural Biotechnology
National Biotechnology Development Agency
Abuja
Nigeria
/
Department of Pharmaceutical Science
North Carolina Central University, Durham
NC 27707
USA

Gunpreet Kaur
University Centre of Excellence in Research
Baba Farid University of Health Sciences, Faridkot
Punjab
India

Harpreet Kaur
Department of Medical Parasitology (PGIMER)
Chandigarh
India

Kamel Hamzaoui
Tunis El Manar University, Medicine Faculty of Tunis, Department of Paediatric and Respiratory Diseases, Abderrahman Mami Hospital, Pavillon B, Ariana, Research Laboratory 19SP02 “Chronic Pulmonary Pathologies: From Genome to Management”
Tunisia

Lokesh Sharan
Department of Pharmacology and Toxicology
National Institute of Pharmaceutical Education and Research (NIPER)
Kolkata 700054, West Bengal
India

Lorretha Chinonye Emenyeonu
Bioresources Development Centre
Owode, National Biotechnology Development Agency
Abuja
Nigeria

Monika Joon
Government College Bahadurgarh
Affiliated to MDU, Rohtak
Haryana
India

Manisha Yadav
Dr. B. R. Ambedkar Centre for Biomedical Research (ACBR)
University of Delhi
Delhi-110007
India

Manisha Yadav
Dr. B. R. Ambedkar Centre for Biomedical Research (ACBR)
University of Delhi
Delhi-110007
India

Noyel Ghosh
Division of Molecular Medicine
Bose Institute, P-1/12, CIT Scheme VII M
Kolkata-700054, West Bengal
India

Navjot Kanwar
University Institute of Pharmaceutical Sciences
Punjab University
Chandigarh
India

Oni Solomon Oluwasunmibare
Bioresources Development Centre, Isanlu
National Biotechnology Development Agency
Abuja
Nigeria

Parames C. Sil
Division of Molecular Medicine
Bose Institute, P-1/12, CIT Scheme VII M
Kolkata-700054, West Bengal
India

Parveen Bansal
University Centre of Excellence in Research
Baba Farid University of Health Sciences, Faridkot
Punjab
India

Priscilla Aondona
Department of Medical Biotechnology
National Biotechnology Development Agency
Abuja
Nigeria

Priya Saha
Department of Pharmacology and Toxicology
National Institute of Pharmaceutical Education and Research (NIPER)-SAS Nagar, Mohali
Punjab, 160062
India

Rashmi Singh
Department of Zoology
MMV, Banaras Hindu University
Varanasi-221002
India

Ravinder Sharma
University Institute of Pharmaceutical Sciences and Research
BFUHS, Faridkot
Punjab
India

Rakesh Singh Dhanda
Celluleris AB, VentureLab
Scheelevägen 15
223 70 Lund
Sweden

Sushweta Mahalanobish
Division of Molecular Medicine
Bose Institute, P-1/12, CIT Scheme VII M
Kolkata-700054, West Bengal
India

Syed Ehtaishamul Haque
Department of Pharmacology
School of Pharmaceutical Education and Research, Jamia Hamdard
New Delhi-110062
India

Sonal Yadav
Dr. B. R. Ambedkar Centre for Biomedical Research (ACBR)
University of Delhi
Delhi-110007
India

Sabrine Louhaichi
Tunis El Manar University, Medicine Faculty of Tunis, Department of Paediatric and Respiratory Diseases, Abderrahman Mami Hospital, Pavillon B, Ariana, Research Laboratory 19SP02 “Chronic Pulmonary Pathologies: From Genome to Management”
Tunisia

Tarimoboere Agbalalah
Department of Medical Biotechnology
National Biotechnology Development Agency
Abuja
Nigeria
/
Department of Anatomy
Faculty of Basic Medical Sciences, Baze University
Abuja
Nigeria

Umar Suleiman Abubakar
Bioresources Development Centre
Kano, National Biotechnology Development Agency
Abuja
Nigeria

Vikas Gupta
University Centre of Excellence in Research
Baba Farid University of Health Sciences, Faridkot
Punjab
India

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