Author: Sencer Taneri

Applied Biomathematics for Nucleic Acid Chemistry and Protein Folding: Quantitative Simulations

eBook: US $29 Special Offer (PDF + Printed Copy): US $54
Printed Copy: US $39
Library License: US $116
ISBN: 978-981-5179-97-2 (Print)
ISBN: 978-981-5179-96-5 (Online)
Year of Publication: 2023
DOI: 10.2174/97898151799651230101

Introduction

This monograph research presents research in applied biomathematics carried out by the author at the beginning of this millennium. Monte Carlo simulations have been widely used by computational biologists to understand stochastics of living systems in biological matter. This work demonstrates how Monte Carlo simulations can help us to understand the nucleic acid structure, biophysics and chemistry.

The author presents research on methods to understand aspects of the molecular dynamics of nucleic acids, DNA melting, evolutionary genetics, protein folding of Crambin and DNA vitrification. The book consists of five chapters and an appendix on the theoretical investigation on 10-12 potential of Hydrogen-Hydrogen covalent bond. Some of the previous research published in İnternational Journal of Modern Physics C and Modern Physics Letters B is extended for additional insight.

Readers will find simple computer algorithms for hard mathematical physics problems such as mesoscopic, fractals, percolation, Metropolis algorithm and Langevin dynamics – many of which are also crucial to understanding experimental results of computer-aided drug discovery and cryopreservation. The author has taken care to explain calculations in a clear manner. All simulations have been conducted using Fortran (f77).

Readership

Advanced researchers and data scientists in the field of molecular dynamics, bioinformatics and systems biology

Preface

The present book is intended to lay out research in Applied Biomathematics carried out by the author at the beginning of this millennium. It involves sample Monte Carlo simulations which have been widely used among scientists to understand stochastic molecular dynamics in biological matter of living systems. The subject material contains research essentially on three aspects of biomolecular structure and dynamics: (i) DNA Melting and DNA Vitrification, (ii) Evolutionary Genetics and Gene Mutation, and (iii) Protein Folding. The book consists of five chapters and an appendix. There have been some extensions to the collection of previous research articles published in International Journal of Modern Physics C and in Modern Physics Letters B which are World Scientific Publishing Journals. The collection of articles benefits from simple computer algorithms for hard mathematical physics problems of the past such as mesoscopic, fractals, percolation, metropolis algorithm and Langevin Dynamics. It can be useful for understanding the pandemic as the consequence of the spread of epidemic, and for understanding the recovery as the result of computer-aided drug discovery and cryopreservation.

Sencer Taneri
University of Southern California
Los Angeles
USA