Editors: Ashok Kumar Jha, Ravi S. Singh

Frontiers In Medicinal Chemistry

Volume 10

eBook: US $69 Special Offer (PDF + Printed Copy): US $117
Printed Copy: US $83
Library License: US $276
ISSN: 1567-2042 (Print)
ISSN: 1875-5763 (Online)
ISBN: 978-981-5165-05-0 (Print)
ISBN: 978-981-5165-04-3 (Online)
Year of Publication: 2023
DOI: 10.2174/97898151650431231001


Frontiers in Medicinal Chemistry is a book series devoted to reviews on research topics relevant to medicinal chemistry and allied disciplines. Frontiers in Medicinal Chemistry covers developments in rational drug design, bioorganic chemistry, high-throughput screening, combinatorial chemistry, compound diversity measurements, drug absorption, drug distribution, metabolism, new and emerging drug targets, natural products, pharmacogenomics, chemoinformatics, and structure-activity relationships. This book series is essential for any medicinal chemist who wishes to be updated on the latest and the most important advances in the field.

This is the tenth volume of the series. The extensive volume brings 11 reviews on a variety of topics including anti-cancer drug therapeutics, food chemistry, toxicology and drug development strategies. The list of topics in this volume includes:

⚬   Isoxazole derivatives as potential pharmacophore for new drug development

⚬   Contemporary trends in drug repurposing: identifying new targets for existing drugs

⚬   Pharmaceutical potential of pyrimidines as antiviral agents

⚬   Drugs and phytochemicals targeting cancer

⚬   Harnessing the neurological properties of indian brain health booster brahmi

⚬   Carcinogenicity of hexavalent chromium and its effects

⚬   Medicinal plants: a future of modern medical system

⚬   Shikonin, a naphthaquinone of commercial importance: its biosynthesis and prospect for use as drugs

⚬   Fast foods: chemical composition and implications for health

⚬   Implications of DNA-acting agents as anticarcinogenic potential in breast cancer therapeutics

⚬   Aloe vera - a medicinal plant as potential therapeutic agents for liver cancer

Readership Medicinal chemists, pharmaceutical research and development professionals, researchers in medicine and life sciences.


In recent times, Medicinal Chemistry has emerged in Chemistry as a very fascinating and challenging area to cope with mysterious diseases, as a result of which this branch of Chemistry has attained prime importance. From the beginning of civilization in ancient times, Chemistry has been designed to serve humankind through Ayurveda, herbal medicines and metals in nano-size for drug delivery. In the Himalayas, there were very good and well-known plants used for the treatment of severe ailments. The ancient concept of Swarna bhasma, iron bhasma, and other bhasmas is nothing but modern time nano drugs. Lead and silver bhasmas were also in practice. There is no doubt that Medicinal Chemistry plays a significant role in the discovery of therapeutic agents or bioactive molecules for use in the treatment of various human ailments. It generally involves chemical, synthetic and computational aspects of identification and modification of molecules known as drugs either from natural or synthetic products.

This book, titled "Frontiers in Medicinal Chemistry," contains diverse topics from different areas of Medicinal Chemistry, including developments in drug discovery and design, identifying new targets for existing drugs through drug repurposing, along screening new and emerging drug targets. In addition, carcinogenicity due to hexavalent chromium and arsenic with a probable mechanism of mismatch DNA repair and proteotoxic stress have been discussed in the chapter of the book. Biosynthetic pathways, biotechnology, biochemistry, molecular biology and related topics from food science have also been incorporated in the book.

I do hope that this book will serve as an important repository of scientific information on Medicinal Chemistry to students, researchers and a broad scientific spectrum. We had long sittings in the calmness of the night and even under the fading stars of dawn, completely away from the din and bustle to complete this monumental treatise. We express our sincere thanks to Senior Research Fellow Sri Sachin Verma “Heavy Metal Remediation Laboratory’’ for providing his computer skills and expertise. I also express my thanks to Dr. Ujjwal Kumar, AIIMS Patna, for showing interest in the present book.

Last but not least, we express our deep sense of gratitude to Prof. D.C Mukherjee for constant encouragement. We sincerely thank and appreciate Bentham Science Publishers for providing an opportunity to complete this project. Finally, we bow before the Almighty, Creator of the Universe, for instilling inner strength in us to complete this arduous task.

Ashok Kumar Jha
Department of Chemistry
T.M. Bhagalpur University
Bhagalpur, Bihar

Ravi S. Singh
Bihar Agriculture University
Sabour, Bihar