Foreword

Oxidative stress is a major contributor to the pathology and pathophysiology of cardiovascular disease and other related human conditions; however, our understanding of the processes and mechanisms is still limited and warrants further studies and dissemination. Drs Elahi, Day-Walsh and Matata have undertaken a momentous task of assembling and organising topical and interesting topics for this book which starts with expositions in the basic science of Redox signaling, oxidative stress in cardiovascular disease (Bashir Matata & Maqsood Elahi), followed by oxidative stress and leukocytes activation (Bashir Matata & Maqsood Elahi). Dr. Priscilla Day-Walsh discusses the role of lipids and oxidation in cardiovascular disease which are hotly debated in the scientific community. Dr. Sferruzzi-Perri and colleagues elucidate the role of maternal factors in programming and progression of cardiovascular disease. The role of microbiomes in cardiovascular diseases (Day-Walsh & Shehata) has become a very important topic of research and medical practice which is a salient chapter of this book. The role of antioxidants in the modulation of inflammation and cardiovascular disease is explained in detail by Dr. Matata and Dr. Elahi. The last two chapters focus on therapeutic approaches focusing on oxidants, nitric oxide, role of nanotechnology (Gajardo et al. and Kogan et al. respectively) which advances our knowledge of their usefulness in clinical practice.

The authors of different chapters in this book are experts in their field at clinical and research levels and have crafted their chapters in a way that has appeal and usability at many levels for colleagues in clinical research, medical practice, and education (doctors, nurses and other health care practitioners). This book will serve as a treatise as an excellent update on the role of oxidation, oxidative stress, and antioxidants in cardiovascular disease and its prevention. Authors and Editors are congratulated to bring this important task and book to fruition.